Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

United States Jewry, 1776-1985

In United States Jewry, 1776-1985, the dean of American Jewish historians, Jacob Rader Marcus, unfolds the history of Jewish immigration, segregation, and integration; of Jewry's cultural exclusiveness and assimilation; of its internal division and indivisible unity; and of its role in the making of America. Characterized by Marcus's impeccable scholarship, meticulous documentation, and readable style, this landmark four-volume set completes the history Marcus began in The Colonial American Jew, 1492-1776. In the fourth and final volume of this set, Marcus deals with the coming and challenge of the East European Jews from 1852 to 1920. He explores settlement and colonization, dispersal to rural areas, life in large cities, the proletarians, the garment industry, the unions, and socialism. He also describes the life of the middle and upper class East European Jew. Special attention is paid to the growth of Zionism. In the epilogue, Marcus writes about the evolution of the "American Jew.

United States Jewry, 1776-1985

In United States Jewry, 1776-1985, the dean of American Jewish historians, Jacob Rader Marcus, unfolds the history of Jewish immigration, segregation, and integration; of Jewry's cultural exclusiveness and assimilation; of its internal division and indivisible unity; and of its role in the making of America. Characterized by Marcus's impeccable scholarship, meticulous documentation, and readable style, this landmark four-volume set completes the history Marcus began in The Colonial American Jew, 1492-1776. Volume I focuses on the American revolution and the early national period, from 1776 to 1840. Marcus examines the role played by Jews in the revolution and discusses important historical and social themes such as politics, commerce, religion, Jewish and American culture, anti-Jewish prejudices, and the phenomenon of assimilation

United States Jewry, 1776-1985

In United States Jewry, 1776-1985, the dean of American Jewish historians, Jacob Rader Marcus, unfolds the history of Jewish immigration, segregation, and integration; of Jewry's cultural exclusiveness and assimilation; of its internal division and indivisible unity; and of its role in the making of America. Characterized by Marcus's impeccable scholarship, meticulous documentation, and readable style, this landmark four-volume set completes the history Marcus began in The Colonial American Jew, 1492-1776. The third volume covers the period from 1860 to 1920, beginning with the Jews, slavery, and the Civil War, and concluding with the rise of Reform Judaism as well as the increasing spirit of secularization that characterized emancipated, prosperous, liberal Jewry before it was confronted by a rising tide of American anti-Semitism in the 1920s

United States Jewry, 1776-1985

In United States Jewry, 1776-1985, the dean of American Jewish historians, Jacob Rader Marcus, unfolds the history of Jewish immigration, segregation, and integration; of Jewry's cultural exclusiveness and assimilation; of its internal division and indivisible unity; and of its role in the making of America. Characterized by Marcus's impeccable scholarship, meticulous documentation, and readable style, this landmark four-volume set completes the history Marcus began in The Colonial American Jew, 1492-1776. The second volume of this seminal work on American Jewry covers the period from 1841 to 1860. Unlike the early Jewish settlers, these immigrants were Ashkenazim from Europe's Germanic countries. Marcus follows the movement of these "German" Jews into all regions west of the Hudson River

A brief introduction to the bibliography of modern Jewish history,

Mimeographed.Mode of access: Internet

The American Rabbinate : a Century of Continuity and Change, 1883-1983

https://digitalcommons.usm.maine.edu/facbooks/1328/thumbnail.jp