The development of microfabricated ion traps towards quantum information and simulation

Trapped ions within Paul traps have shown to be a promising architecture in the realisation of a quantum information processor together with the ability of providing quantum simulations. Linear Paul traps have demonstrated long coherence times with ions being well isolated from the environment, single and multi-qubit gates and the high fidelity detection of states. The scalability to large number of qubits, incorporating all the previous achievements requires an array of linear ion traps. Microfabrication techniques allow for fabrication and micron level accuracy of the trap electrode dimensions through photolithography techniques. The first part of this thesis presents the experiential setup and trapping of Yb+ ions needed to test large ion trap arrays. This include vacuum systems that can host advanced symmetric and asymmetric ion traps with up to 90 static voltage control electrodes. Demonstration of a single trapped Yb+ ion within a two-layer macroscopic ion trap is presented. with an ion-electrode distance of 310(10) μm. The anomalous heating rate and spectral noise density of the trap was measured, a main form of decoherence within ion traps. The second half of this thesis presents the design and fabrication of multi-layer asymmetric ion traps. This allows for isolated electrodes that cannot be accessed via surface pathways, allowing for higher density of electrodes as well as creating novel trap designs that allow for the potential of quantum simulations to be demonstrated. These include two-dimensional lattices and ring trap designs in which the isolated electrodes provide more control in the ion position. For the microfabrication of these traps I present a novel high-aspect ratio electroplated electrode design that provides shielding of the dielectric layer. This provides a means to mitigate stray electric field due to charge build up on the dielectric surfaces. Electrical testing of the trap structures was performed to test bulk breakdown and surface flashover of the ion trap architectures. Results showed sufficient isolation between electrodes for both radio frequency and static breakdown. Surface flashover voltage measurements over the dielectric layer showed an improvement of more than double over previous results using a new fabrication technique. This will allow for more powerful ion trap chips needed for the next generation of microfabricated ion trap arrays for scalable quantum technologies

REGULATORY APPROVAL OF NEW MEDICAL DEVICES: A CROSS SECTIONAL STUDY

Objective To investigate the regulatory approval of new medical devices. Design Cross sectional study of new medical devices reported in the biomedical literature. Data sources PubMed was searched between 1 January 2000 and 31 December 2004 to identify clinical studies of new medical devices. The search was carried out during this period to allow time for regulatory approval. Eligibility criteria for study selection Articles were included if they reported a clinical study of a new medical device and there was no evidence of a previous clinical study in the literature. We defined a medical device according to the US Food and Drug Administration as an “instrument, apparatus, implement, machine, contrivance, implant, in vitro reagent, or other similar or related article.” Main outcome measures Type of device, target specialty, and involvement of academia or of industry for each clinical study. The FDA medical databases were then searched for clearance or approval relevant to the device. Results 5574 titles and abstracts were screened, 493 full text articles assessed for eligibility, and 218 clinical studies of new medical devices included. In all, 99/218 (45%) of the devices described in clinical studies ultimately received regulatory clearance or approval. These included 510(k) clearance for devices determined to be “substantially equivalent” to another legally marketed device (78/99; 79%), premarket approval for high risk devices (17/99; 17%), and others (4/99; 4%). Of these, 43 devices (43/99; 43%) were actually cleared or approved before a clinical study was published. Conclusions We identified a multitude of new medical devices in clinical studies, almost half of which received regulatory clearance or approval. The 510(k) pathway was most commonly used, and clearance often preceded the first published clinical study

Fifty Years of Innovation in Plastic Surgery

© 2016 The Korean Society of Plastic and Reconstructive Surgeons.Background Innovation has molded the current landscape of plastic surgery. However, documentation of this process only exists scattered throughout the literature as individual articles. The few attempts made to profile innovation in plastic surgery have been narrative, and therefore qualitative and inherently biased. Through the implementation of a novel innovation metric, this work aims to identify and characterise the most prevalent innovations in plastic surgery over the last 50 years. Methods Patents and publications related to plastic surgery (1960 to 2010) were retrieved from patent and MEDLINE databases, respectively. The most active patent codes were identified and grouped into technology areas, which were subsequently plotted graphically against publication data. Expert-derived technologies outside of the top performing patents areas were additionally explored. Results Between 1960 and 2010, 4,651 patents and 43,118 publications related to plastic surgery were identified. The most active patent codes were grouped under reconstructive prostheses, implants, instruments, non-invasive techniques, and tissue engineering. Of these areas and other expert-derived technologies, those currently undergoing growth include surgical instruments, implants, non-invasive practices, transplantation and breast surgery. Innovations related to microvascular surgery, liposuction, tissue engineering, lasers and prostheses have all plateaued. Conclusions The application of a novel metric for evaluating innovation quantitatively outlines the natural history of technologies fundamental to the evolution of plastic surgery. Analysis of current innovation trends provides some insight into which technology domains are the most active

The Power of Empathy: A Critical Narrative Inquiry of Cultural Competencies in New Teachers

Given the large homogeneous workforce of predominately White, middle-class female K–12 educators combined with the rising population of diverse students in the United States and the disproportionate achievement gap of students of color compared to their White peers, I sought to discover how new millennial educators defined and used empathy to build their own cultural competencies as well as discover how these teachers used empathy to strengthen the teacherstudent relationships across cultural differences. Using the conceptual frameworks of Paulo Freire’s (1970) pedagogy and Wang et al.’s (2003) definition of ethno-cultural empathy, I conducted a critical narrative inquiry of five first-year teachers who did not share the racial or ethnic background of the majority of their students of color. From the participants’ stories, six major themes surfaced: (a) the role of empathy in the teacher-student relationships, (b) the struggle between empathy and sympathy, (c) their contrasting views on empathy and content, (d) the relationship between empathy and cultural competency, (e) the importance of empathy related to trauma, and (f) the personal limitations of empathy. I present a proposal for a new theoretical framework resulting from the symbiotic relationship of ethno-cultural empathy and critical pedagogy, called Critical Empathy, as well as recommendations for teacher formation institutions to prioritize an empathy formation that focuses on critical empathy development, self-awareness, administrative management, and self-care strategies

Optimisation of two-dimensional ion trap arrays for quantum simulation

The optimisation of two-dimensional (2D) lattice ion trap geometries for trapped ion quantum simulation is investigated. The geometry is optimised for the highest ratio of ion-ion interaction rate to decoherence rate. To calculate the electric field of such array geometries a numerical simulation based on a "Biot-Savart like law" method is used. In this article we will focus on square, hexagonal and centre rectangular lattices for optimisation. A method for maximising the homogeneity of trapping site properties over an array is presented for arrays of a range of sizes. We show how both the polygon radii and separations scale to optimise the ratio between the interaction and decoherence rate. The optimal polygon radius and separation for a 2D lattice is found to be a function of the ratio between rf voltage and drive frequency applied to the array. We then provide a case study for 171Yb+ ions to show how a two-dimensional quantum simulator array could be designed

Quantifying innovation in surgery

Objectives: The objectives of this study were to assess the applicability of patents and publications as metrics of surgical technology and innovation; evaluate the historical relationship between patents and publications; develop a methodology that can be used to determine the rate of innovation growth in any given health care technology. Background: The study of health care innovation represents an emerging academic field, yet it is limited by a lack of valid scientific methods for quantitative analysis. This article explores and cross-validates 2 innovation metrics using surgical technology as an exemplar. Methods: Electronic patenting databases and the MEDLINE database were searched between 1980 and 2010 for “surgeon” OR “surgical” OR “surgery.” Resulting patent codes were grouped into technology clusters. Growth curves were plotted for these technology clusters to establish the rate and characteristics of growth. Results: The initial search retrieved 52,046 patents and 1,801,075 publications. The top performing technology cluster of the last 30 years was minimally invasive surgery. Robotic surgery, surgical staplers, and image guidance were the most emergent technology clusters. When examining the growth curves for these clusters they were found to follow an S-shaped pattern of growth, with the emergent technologies lying on the exponential phases of their respective growth curves. In addition, publication and patent counts were closely correlated in areas of technology expansion. Conclusions: This article demonstrates the utility of publically available patent and publication data to quantify innovations within surgical technology and proposes a novel methodology for assessing and forecasting areas of technological innovation

Social living labs for digital participation: designing with regional and rural communities

“Fostering digital participation through Living Labs in regional and rural Australian communities,” is a three year research project funded by the Australian Research Council. The project aims to identify the specific digital needs and practices of regional and rural residents in the context of the implementation of high speed internet. It seeks to identify new ways for enabling residents to develop their digital confidence and skills both at home and in the community. This two-day symposium will bring together researchers and practitioners from diverse backgrounds to discuss design practices in social living labs that aim to foster digital inclusion and participation. Day one will consist of practitioner and research reports, while day two will provide an opportunity for participants to imagine and design future digital participation strategies. Academic participants will also have an opportunity to contribute to a refereed edited volume by Chandos Publishing (an imprint of Elsevier)

Kimera2: Robust and Accurate Metric-Semantic SLAM in the Real World

We present improvements to Kimera, an open-source metric-semantic visual-inertial SLAM library. In particular, we enhance Kimera-VIO, the visual-inertial odometry pipeline powering Kimera, to support better feature tracking, more efficient keyframe selection, and various input modalities (eg monocular, stereo, and RGB-D images, as well as wheel odometry). Additionally, Kimera-RPGO and Kimera-PGMO, Kimera's pose-graph optimization backends, are updated to support modern outlier rejection methods - specifically, Graduated-Non-Convexity - for improved robustness to spurious loop closures. These new features are evaluated extensively on a variety of simulated and real robotic platforms, including drones, quadrupeds, wheeled robots, and simulated self-driving cars. We present comparisons against several state-of-the-art visual-inertial SLAM pipelines and discuss strengths and weaknesses of the new release of Kimera. The newly added features have been released open-source at https://github.com/MIT-SPARK/Kimera.Comment: Presented at ISER 202

A phenomenological study of star formation and chemical evolution in nearby galaxies

The main aims of this thesis are: (a) an investigation into the evolutionary histories of nearby galaxies, via the use of ultraviolet-infrared colour-mass diagrams, to uncover the dominant mechanism driving nearby galaxy evolution; (b) the determination of the impact of feedback from active galactic nuclei on star formation; and (c) a study of chemical evolution of star-forming galaxies in different environments. The analysis confirms recent observations of a population of late-type galaxies with reduced levels of star formation. I demonstrate that feedback from active nuclei is unlikely to be the dominant mechanism quenching star formation and driving the evolution of thee late-type galaxies. In fact, galaxies with quenched star formation are typically gas-deficient cluster galaxies, suggesting that environmental effects are responsible for removing the gas required to fuel star formation. A fraction of quenched late-type galaxies are, however, not gas deficient, and form a more heterogeneous class of objects with more complex evolutionary histories. On the other hand, the chemical evolution of star-forming galaxies, as traced by the stellar mass-metallicity relation, is shown to be invariant with environment, suggesting that internal processes drive chemical evolution. The clear observational evidence presented here indicates that, in the concordance model of galaxy formation and evolution, environmental effects must be taken into account in order to gain a better understanding of galaxy evolution in the local universe.EThOS - Electronic Theses Online ServiceGBUnited Kingdo