100 research outputs found
On the spatial Markov property of soups of unoriented and oriented loops
We describe simple properties of some soups of unoriented Markov loops and of
some soups of oriented Markov loops that can be interpreted as a spatial Markov
property of these loop-soups. This property of the latter soup is related to
well-known features of the uniform spanning trees (such as Wilson's algorithm)
while the Markov property of the former soup is related to the Gaussian Free
Field and to identities used in the foundational papers of Symanzik, Nelson,
and of Brydges, Fr\"ohlich and Spencer or Dynkin, or more recently by Le Jan
Hard-core Yukawa model for two-dimensional charge stabilized colloids
The hyper-netted chain (HNC) and Percus-Yevick (PY) approximations are used
to study the phase diagram of a simple hard-core Yukawa model of
charge-stabilized colloidal particles in a two-dimensional system. We calculate
the static structure factor and the pair distribution function over a wide
range of parameters. Using the statics correlation functions we present an
estimate for the liquid-solid phase diagram for the wide range of the
parameters.Comment: 7 pages, 9figure
Pure type I supergravity and DE(10)
We establish a dynamical equivalence between the bosonic part of pure type I
supergravity in D=10 and a D=1 non-linear sigma-model on the Kac-Moody coset
space DE(10)/K(DE(10)) if both theories are suitably truncated. To this end we
make use of a decomposition of DE(10) under its regular SO(9,9) subgroup. Our
analysis also deals partly with the fermionic fields of the supergravity theory
and we define corresponding representations of the generalized spatial Lorentz
group K(DE(10)).Comment: 28 page
Mortality, outcomes, costs, and use of medicines following a first heart failure hospitalization: EVOLUTION HF
Background:
There are few contemporary data on outcomes, costs, and treatment following a hospitalization for heart failure (hHF) in epidemiologically representative cohorts.
Objectives:
The study sought to describe rehospitalizations, hospitalization costs, use of guideline-directed medical therapy (GDMT) (renin-angiotensin system inhibitors, sacubitril/valsartan, beta-blockers, mineralocorticoid receptor antagonists, and sodium-glucose cotransporter-2 inhibitors), and mortality after hHF.
Methods:
EVOLUTION HF (Utilization of Dapagliflozin and Other Guideline Directed Medical Therapies in Heart Failure Patients: A Multinational Observational Study Based on Secondary Data) is an observational, longitudinal cohort study using data from electronic health records or claims data sources in Japan, Sweden, the United Kingdom, and the United States. Adults with a first hHF discharge between 2018 and 2022 were included. One-year event rates per 100 patient-years (ERs) for death and rehospitalizations (with a primary diagnosis of heart failure (HF), chronic kidney disease [CKD], myocardial infarction, stroke, or peripheral artery disease) were calculated. Hospital health care costs were cumulatively summarized. Cumulative GDMT use was assessed using Kaplan-Meier estimates.
Results:
Of 263,525 patients, 28% died within the first year post-hHF (ER: 28.4 [95% CI: 27.0-29.9]). Rehospitalizations were mainly driven by HF (ER: 13.6 [95% CI: 9.8-17.4]) and CKD (ER: 4.5 [95% CI: 3.6-5.3]), whereas the ERs for myocardial infarction, stroke, and peripheral artery disease were lower. Health care costs were predominantly driven by HF and CKD. Between 2020 and 2022, use of renin-angiotensin system inhibitors, sacubitril/valsartan, beta-blockers, and mineralocorticoid receptor antagonists changed little, whereas uptake of sodium-glucose cotransporter-2 inhibitors increased 2- to 7-fold.
Conclusions:
Incident post-hHF rehospitalization risks and costs were high, and GDMT use changed little in the year following discharge, highlighting the need to consider earlier and greater implementation of GDMT to manage risks and reduce costs
Magnetic Fields, Relativistic Particles, and Shock Waves in Cluster Outskirts
It is only now, with low-frequency radio telescopes, long exposures with
high-resolution X-ray satellites and gamma-ray telescopes, that we are
beginning to learn about the physics in the periphery of galaxy clusters. In
the coming years, Sunyaev-Zeldovich telescopes are going to deliver further
great insights into the plasma physics of these special regions in the
Universe. The last years have already shown tremendous progress with detections
of shocks, estimates of magnetic field strengths and constraints on the
particle acceleration efficiency. X-ray observations have revealed shock fronts
in cluster outskirts which have allowed inferences about the microphysical
structure of shocks fronts in such extreme environments. The best indications
for magnetic fields and relativistic particles in cluster outskirts come from
observations of so-called radio relics, which are megaparsec-sized regions of
radio emission from the edges of galaxy clusters. As these are difficult to
detect due to their low surface brightness, only few of these objects are
known. But they have provided unprecedented evidence for the acceleration of
relativistic particles at shock fronts and the existence of muG strength fields
as far out as the virial radius of clusters. In this review we summarise the
observational and theoretical state of our knowledge of magnetic fields,
relativistic particles and shocks in cluster outskirts.Comment: 34 pages, to be published in Space Science Review
Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial
Aims:
Both left ventricular (LV) and left atrial (LA) dysfunction and remodelling contribute to adverse outcomes in heart failure with reduced ejection fraction (HFrEF). Danicamtiv is a novel, cardiac myosin activator that enhances cardiomyocyte contraction.
Methods and results:
We studied the effects of danicamtiv on LV and LA function in nonâclinical studies (ex vivo : skinned muscle fibres and myofibrils; in vivo : dogs with heart failure) and in a randomized, doubleâblind, singleâ and multipleâdose phase 2a trial in patients with stable HFrEF (placebo, n =â10; danicamtiv, n =â30; 50â100âmg twice daily for 7âdays). Danicamtiv increased ATPase activity and calcium sensitivity in LV and LA myofibrils/muscle fibres. In dogs with heart failure, danicamtiv improved LV stroke volume (+10.6 mL, P <â0.05) and LA emptying fraction (+10.7%, P <â0.05). In patients with HFrEF (mean age 60âyears, 25% women, ischaemic heart disease 48%, mean LV ejection fraction 32%), treatmentâemergent adverse events, mostly mild, were reported in 17 patients (57%) receiving danicamtiv and 4 patients (40%) receiving placebo. Danicamtiv (at plasma concentrations â„2000âng/mL) increased stroke volume (up to +7.8 mL, P <â0.01), improved global longitudinal (up to â1.0%, P <â0.05) and circumferential strain (up to â3.3%, P <â0.01), decreased LA minimal volume index (up to â2.4 mL/m2, P <â0.01) and increased LA function index (up to 6.1, P <â0.01), when compared with placebo.
Conclusions:
Danicamtiv was well tolerated and improved LV systolic function in patients with HFrEF. A marked improvement in LA volume and function was also observed in patients with HFrEF, consistent with preâclinical findings of direct activation of LA contractility
Country-level gender inequality is associated with structural differences in the brains of women and men
The evolution of language: a comparative review
For many years the evolution of language has been seen as a disreputable topic, mired in fanciful "just so stories" about language origins. However, in the last decade a new synthesis of modern linguistics, cognitive neuroscience and neo-Darwinian evolutionary theory has begun to make important contributions to our understanding of the biology and evolution of language. I review some of this recent progress, focusing on the value of the comparative method, which uses data from animal species to draw inferences about language evolution. Discussing speech first, I show how data concerning a wide variety of species, from monkeys to birds, can increase our understanding of the anatomical and neural mechanisms underlying human spoken language, and how bird and whale song provide insights into the ultimate evolutionary function of language. I discuss the ââdescended larynxâ â of humans, a peculiar adaptation for speech that has received much attention in the past, which despite earlier claims is not uniquely human. Then I will turn to the neural mechanisms underlying spoken language, pointing out the difficulties animals apparently experience in perceiving hierarchical structure in sounds, and stressing the importance of vocal imitation in the evolution of a spoken language. Turning to ultimate function, I suggest that communication among kin (especially between parents and offspring) played a crucial but neglected role in driving language evolution. Finally, I briefly discuss phylogeny, discussing hypotheses that offer plausible routes to human language from a non-linguistic chimp-like ancestor. I conclude that comparative data from living animals will be key to developing a richer, more interdisciplinary understanding of our most distinctively human trait: language
Suplementação de selĂȘnio e vitamina E sobre a contagem de cĂ©lulas somĂĄticas no leite de vacas da raça Holandesa
InfluĂȘncia do Plano Nutricional sobre o Desempenho de Bezerros Holandeses para Produção de Vitelos
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