Fermented wheat germ extract - nutritional supplement or anticancer drug?

<p>Abstract</p> <p>Background</p> <p>Fermented wheat germ extract (FWGE) is a multisubstance composition and, besides others, contains 2-methoxy benzoquinone and 2, 6-dimethoxy benzoquinone which are likely to exert some of its biological effects. FWGE interferes with anaerobic glycolysis, pentose cycle and ribonucleotide reductase. It has significant antiproliferative effects and kills tumor cells by the induction of apoptosis via the caspase-poly [ADP-ribose] polymerase-pathway. FWGE interacts synergistically with a variety of different anticancer drugs and exerted antimetastatic properties in mouse models. In addition, FWGE modulates immune response by downregulation of MHC-I complex and the induction of TNF-α and various interleukins. Data in the F-344 rat model provide evidence for a colon cancer preventing effect of FWGE.</p> <p>Clinical data from a randomized phase II trial in melanoma patients indicate a significant benefit for patients treated with dacarbazine in combination with FWGE in terms of progression free survival (PFS) and overall survival (OS). Similarly, data from studies in colorectal cancer suggested a benefit of FWGE treatment. Besides extension of OS and PFS, FWGE improved the quality of life in several studies.</p> <p>Conclusion</p> <p>In conclusion, available data so far, justify the use of FWGE as a non-prescription medical nutriment for cancer patients. Further randomized, controlled and large scale clinical studies are mandatory, to further clarify the value of FWGE as a drug component of future chemotherapy regimens.</p

Forex trading based on the technical analysis

Szakdolgozatomban bemutatom a nemzetközi devizapiachoz kapcsolódó alapfogalmakat, melyek elengedhetetlenül szükségesek a tőzsde ezen piacának megértéséhez. A tőzsdei árfolyamok előrejelzéséhez és elemzéséhez szolgáló technikai analízist négy fő szerkezeti egységben mutatom be. Az első részben a technikai elemzés fogalma és általános jellemzői, a különböző grafikontípusok, valamint a japán gyertyák eredete és felépítése kerül bemutatásra.Ezt követően külön szerkezeti egységben tárgyalom a trendelemzés során alkalmazott elemzési technikákat.A technika elemzés harmadik fő területét az indikátorok alkotják, amelyek típusait az általuk vizsgált területek szerint, négy csoportra osztva ismertetem.A negyedik szerkezeti egységben a technikai alakzatok elemzése következik három csoportra bontva.Szakdolgozatom befejező részeként a két legjelentősebb azon tőzsdei elméletet foglalom össze, amelyek nélkül a mai modern technikai elemzés kifejlődése nem valósulhatott volna meg.Szakdolgozatom fő célja a tőzsdei kereskedés, kiváltképp a Forex piacán történő devizakereskedés során leggyakrabban használt elemzési eszközök gyakorlati alkalmazhatóságának bemutatása volt. Ezen kívül igyekeztem betekintést nyújtani, hogy mi is az a Forex, hogyan működik, és milyen lehetőségeket kínál a „hétköznapi” ember számára.BSc/BAPénzügy és számvite

Media and Popular Culture in James Joyce's Ulysses

In my thesis I will try to investigate the ways Joyce portrays this new consciousness in Ulysses. I will attempt to demonstrate the effect of various types of media on the writer’s poetics as well as his critique of them. Joyce’s text demands much from its readers and it has proved to offer so many ways of interpretation that one might find it helpful to explore some aspects and concepts related to Joyce’s poetics and influences.egyetemiangol nyelv és irodalo

Történelem, emlékezet, cenzúra: A tanú mint emlékezethely

My paper investigates Péter Bacsó’s film, A tanú (The Witness) as a lieu de mémoire. Shot in 1969, the film was banned shortly after its first screenings by the socialist censorship. One of the main reasons behind this was the way the film violated the politics of memory of the Kádár-era. However, the work became a cult film in Hungary. A decade later, the regime enabled the public screenings and the movie was included in the programmes of international film festivals. My essay attempts to describe how the film’s genre (as a satire), its relation to previous periods of Hungarian history (especially the years of the Rákosi- and the Kádár-era), and the mechanisms of socialist censorship contributed to its status as a lieu de mémoire today.My paper investigates Péter Bacsó’s film, A tanú (The Witness) as a lieu de mémoire. Shot in 1969, the film was banned shortly after its first screenings by the socialist censorship. One of the main reasons behind this was the way the film violated the politics of memory of the Kádár-era. However, the work became a cult film in Hungary. A decade later, the regime enabled the public screenings and the movie was included in the programmes of international film festivals. My essay attempts to describe how the film’s genre (as a satire), its relation to previous periods of Hungarian history (especially the years of the Rákosi- and the Kádár-era), and the mechanisms of socialist censorship contributed to its status as a lieu de mémoire today

Importance of initial coronary artery flow after heart procurement to assess heart viability before transplantation.

International audienceBACKGROUND: The objective of this study was to evaluate different tests of heart viability in a pig model of warm ischemia. METHODS AND RESULTS: Pig hearts (n = 30) were submitted to 0 (= group I), 10 (group II), 20 (group III), 30 (group IV), and 60 (group V) minutes of in situ warm ischemia (animal exsanguination). Hearts were removed, then flushed with cardioplegic solution for 3 minutes at a fixed pressure of 60 cm H2O, and edema formation, initial coronary flow, and ionic composition (Na+, K+, and Ca++) of coronary sinus effluent were evaluated. Hearts were then stored for 2 hours in a cold (4 degrees C) preservation solution. Myocardial biopsies (and evaluation of energetic index) were performed, then the hearts were reperfused for 30 minutes with whole blood with an in vitro functional testing system. No edema occurred during cardioplegic flush in the hearts in groups I through IV, but a 37 +/- 11% weight increase (P < .001) occurred in hearts in group V. There was a progressive decrease in initial coronary flow with the increase in the duration of warm ischemia (70 +/- 14 mL/min per 100 g of tissue in group I and 52 +/- 9, 41 +/- 16, 25 +/- 11, and 23 +/- 5 mL/min per 100 g, respectively, in groups II through V (P < .01 to P < .001 versus group I). Initial coronary flow was positively correlated with the energetic index (r = .84, P < .001), and the left ventricle developed pressure at reperfusion (r = .90, P < .001). Finally, there were significant differences between hearts in the control group and those in group V for calcium and sodium release (lower in the control group; P < .001 and P < .01, respectively) and for potassium removal (lower in group V, P < .05). CONCLUSIONS: These data suggest that early measurement of coronary flow after removal of the heart may help to assess heart viability before transplantation. This approach may provide a comprehensive clinical evaluation to increase the number of hearts available for transplantation among those that are rejected in the absence of accurate criteria of viability