Examples of 8-oxo-dG radioactive spots as detected by 32P-postlabelling (left panel).

<p>For each sample the lower spot is the origin of chromatography, the upper spot 8-oxo-dG. Linear regression analysis (right panel) indicates that oxidative DNA damage in TM (horizontal axis) was significantly (r = +0.647, P<0.0001) correlated with age (vertical axis). A significant relationship between DNA oxidative damage and autophagy activation as measured by LC3 II/I ratio was detected (r = +0.211, P = 0.047) (lower panel).</p

Western blot analysis of autophagy markers in human trabecular meshwork.

<p>(a) LC3II/I ratio was higher in elder (>60 years old) as compared to younger (<60 years old) subjects. (b) Conversely, p62 was lower in older subjects. These findings reflect the occurrence of an age-dependent blockage in autophagy as occurring in the TM. (c) Evaluation of LC3I, LC3II, and p62 proteins in the TM by Western blot. Protein amounts were compared at different age categories.</p

Mean scores (with 95% confidence intervals) estimated for DS individuals (DS) and euploid controls (C) in each olfactory subtest (threshold, discrimination, identification), and the global test (TDI) according to age class (young adult [<30y], left panel; older adult [≥30y], right panel).

<p>Olfactory performance (adjusted by sex) was significantly lower in DS than controls for any tasks and TDI in both age classes (P<0.001 for all, black bars). Identification score was significantly higher in young adults than older adults both for controls (P = 0.016) and DS (P = 0.031, red bars).</p

Primary antibodies used for western blots protein analysis in trabecular meshwork.

<p>Primary antibodies used for western blots protein analysis in trabecular meshwork.</p

Ecole d'apprentissage [rue de Babylone, confection de patrons de couture] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 98899Appartient à l’ensemble documentaire : Pho20RolImage de press

Pearson's correlations of particulate matter (PM) concentrations, considered as a whole (PM₁₀) or subdivided in the finest (PM_2.5) and the coarse component (PM_10-2.5), with activated partial thromboplastin time (aPTT) and prothrombin time (PT).^*

*<p>: This analysis was performed in a subgroup of patients admitted to Emergency Department for mild respiratory symptoms, without active thrombosis and not taking anticoagulant therapy, for whom data about coagulation times were available (n = 102).</p

Coarse particulate matter (PM_10-2.5) and daily admissions to the Emergency Department for venous thromboembolism (VTE).

<p>Data are presented as mean level of PM_10-2.5 concentration (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0034831#pone-0034831-g002" target="_blank">Figure 2A</a>) and prevalence of days with high PM_10-2.5 concentration, defined as higher than the 75^th percentile – 19 mcg/m³ (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0034831#pone-0034831-g002" target="_blank">Figure 2B</a>), according to the number of daily admissions to the Emergency Department for VTE.</p

Seasonal trend of total, fine, and coarse particulate matter (PM₁₀, PM_2.5, and PM_10-2.5) concentrations during the study period.

<p>In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0034831#pone-0034831-g001" target="_blank">Figure 1A</a>, PM₁₀ levels are represented by the orange line and the area under the curve is divided in the 2 components, PM_2.5 represented by the green area and PM_10-2.5 represented by the ochre yellow area. In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0034831#pone-0034831-g001" target="_blank">Figure 1B</a>, the seasonal trend of PM_10-2.5 concentrations is separately represented and related with data of daily admissions for venous thromboembolism (VTE). The dashed line represents the PM_10-2.5 75^th percentile, at 19 µg/m³.</p

Association between daily hospital referral for venous thromboembolism (VTE) and coarse particulate matter (PM_10-2.5) concentration at different time-lags.

<p>The association was estimated by using distributed lag non-linear models with VTE risk as outcome and time-lags expressed as the number of previous days. Only the current-day (lag 0) PM_2.5-10 levels presented a significant association with VTE risk.</p

WBV-associated changes in several outcome measurements in a group (n = 22) of exercising male participants.

<p>Data are mean±SD.</p