Frequency-locked chaotic opto-RF oscillator

A driven opto-RF oscillator, consisting of a dual-frequency laser (DFL) submitted to frequency-shifted feedback, is studied experimentally and numerically in a chaotic regime. Precise control of the reinjection strength and detuning permits to isolate a parameter region of bounded-phase chaos, where the opto-RF oscillator is frequency-locked to the master oscillator, in spite of chaotic phase and intensity oscillations. Robust experimental evidence of this synchronization regime is found and phase noise spectra allows to compare phase-locking and bounded-phase chaos regimes. In particular, it is found that the long-term phase stability of the master oscillator is well transferred to the opto-RF oscillator even in the chaotic regime

Measuring the universal synchronization properties of coupled oscillators across the Hopf instability

When a driven oscillator loses phase-locking to a master oscillator via a Hopf bifurcation, it enters a bounded-phase regime in which its average frequency is still equal to the master frequency, but its phase displays temporal oscillations. Here we characterize these two synchronization regimes in a laser experiment, by measuring the spectrum of the phase fluctuations across the bifurcation. We find experimentally, and confirm numerically, that the low frequency phase noise of the driven oscillator is strongly suppressed in both regimes in the same way. Thus the long-term phase stability of the master oscillator is transferred to the driven one, even in the absence of phase-locking. The numerical study of a generic, minimal model suggests that such behavior is universal for any periodically driven oscillator near a Hopf bifurcation point.Comment: 5 pages, 5 figure

A 2D nanosphere array for atomic spectroscopy

We are interested in the spectroscopic behaviour of a gas confined in a micrometric or even nanometric volume. Such a situation could be encountered by the filling-up of a porous medium, such as a photonic crystal, with an atomic gas. Here, we discuss the first step of this program, with the generation and characterization of a self-organized 2D film of nanospheres of silica. We show that an optical characterization by laser light diffraction permits to extract some information on the array structure and represents an interesting complement to electron microscopy.Comment: accept\'e pour publication \`a Annales de Physique- proceedings of COLOQ1

Excitable-like chaotic pulses in the bounded-phase regime of an opto-radiofrequency oscillator

We report theoretical and experimental evidence of chaotic pulses with excitable-like properties in an opto-radiofrequency oscillator based on a self-injected dual-frequency laser. The chaotic attractor involved in the dynamics produces pulses that, albeit chaotic, are quite regular: They all have similar amplitudes, and are almost periodic in time. Thanks to these features, the system displays properties that are similar to those of excitable systems. In particular, the pulses exhibit a threshold-like response, of well-defined amplitude, to perturbations, and it appears possible to define a refractory time. At variance with excitability in injected lasers, here the excitable-like pulses are not accompanied by phase slips.Comment: 2nd versio

Dual-Frequency 780-nm Ti:Sa Laser for High Spectral Purity Tunable CW THz Generation

International audience— A two-axis, two-polarization, dual-frequency Ti:Sa laser optimized for high spectral purity CW-THz generation is demonstrated. The laser output power is 50mW. Its mean emission wavelength is optimized around 780nm in order to suit the maximum efficiency of low temperature grown GaAs photomixers. Despite the extremely wide gain bandwidth of Ti:Sa, a proper intracavity filtering design, adapted to this particular laser architecture, enables tunable and single-frequency operation of each laser mode. The resulting beatnote is shown to be tunable between DC and 1.5 THz by steps of 82GHz. Its linewidth is narrower than 30 kHz without any active stabilization or cavity insolation

Photonic microwave oscillator based on monolithic DFB lasers with frequency-shifted feedback

International audienceA photonic oscillator, locked to a master RF synthesiser, was built by using a monolithic dual-wavelength DFB semiconductor laser submitted to a frequency-shifted optical feedback. A [3; 10] GHz tuning range is reported, with a phase noise level lower than −70 dBrad2/Hz at a 10 Hz offset from the carrier

EUREKA study - The evaluation of real-life use of a biophotonic system in chronic wound management: An interim analysis

Objective: Interest has grown regarding photobiomodulation (PBM) with low-level light therapy, which has been shown to positively affect the stages of the wound healing process. In a real-life context clinical setting, the objective of the EUREKA study was to investigate efficacy, safety, and quality of life associated with the use of a BioPhotonic gel (LumiHeal\u2122) in the treatment of chronic wounds such as venous leg ulcers (VLUs), diabetic foot ulcers (DFUs), and pressure ulcers (PUs). This BioPhotonic gel represents a new, first-in-class emission spectrum of light, including fluorescence, to induce PBM and modulate healing. Design: The multicenter, prospective, interventional, uncontrolled, open-label study enrolled 100 patients in 12 wound centers in Italy. We performed an early interim analysis based on the first 33 subjects (13 VLU, 17 DFU, 3 PU) in seven centers who completed the study. Main results: Seventeen patients (52%) achieved total wound closure (full re-epithelialization for 2 weeks) during the study period. Two patients (6%) were considered \u201calmost closed\u201d (decrease of the wound area of more than 90% at study end) and three others (9%) were considered \u201cready for skin grafting\u201d. No related serious adverse events were observed, and the compliance was excellent. After the treatment, the average time to \u201cpain-free\u201d was 11.9 days in the VLU group. Quality of life was improved with overall increase of 26.4% of the total score (Cardiff Wound Impact Schedule, p=0.001). Conclusion: The study revealed a positive efficacy profile of the BioPhotonic gel in promoting wound healing and reactivating the healing process in different types of chronic, hard-to-heal wounds. The treatment was shown to be safe and well tolerated by the patients, and a reduction of pain perception was also detected during the treatment period. The improvement of the quality of life was accompanied by a high level of clinician satisfaction

Application of Small Epigenetic Modulators in Pediatric Medulloblastoma

Medulloblastoma is one of the most frequent among pediatric brain tumors, and it has been classified in various subgroups. Some of them already benefit from quite good therapeutic options, whereas others urgently need novel therapeutic approaches. Epigenetic modulators have long been studied in various types of cancer. Within this review, we summarize the main preclinical studies regarding epigenetic targets (such as HDAC, SIRT, BET, EZH2, G9a, LSD1, and DNMT) inhibitors in medulloblastoma. Furthermore, we shed light on the increasing number of applications of drug combinations as well as hybrid compounds involving epigenetic mechanisms. Nevertheless, in the studies published so far, mainly un-specific or old modulators have been used, and the PKs (brain permeability) have not been well-evaluated. Thus, these findings should be considered as a starting point for further improvement and not as a final result

Accrochage de fréquence sans accrochage de phase de deux modes laser couplés

We study, experimentally and numerically, the synchronization properties of two laser modes. In order to stabilize the frequency difference, we introduce a coherent coupling by optical feedback. For a given coupling strength, we observe three synchronization regimes, depending on the detuning between the uncoupled modes. For a sufficiently weak detuning, the beat-note phase is fixed. Conversely, for strong detuning, the two modes oscillate almost independently. Besides these familiar behaviors, we identify an intermediate situation, where the relative phase fluctuates but remains bounded, and frequency locking is preserved, in spite of the absence of phase locking