Relationship between temperament and anxiety disorders: a systematic review

The relationship between anxiety disorders and personality traits, in their temperamental and character dimensions, has been the subject of numerous studies using the dimensional approach of the psychobiological personality. The aim of this review was to identify temperament and character traits linked both to anxiety symptoms and to specific anxious disorders comparing the data obtained from studies using the two forms of Cloninger temperament and character inventory (TCI and TCI-R). Besides the study aimed to identify, through the comparison of data, the most appropriate model to represent the relationship between personality traits and anxiety disorders. Results showed a high direct correlation between the temperamental dimension of Harm Avoidance and anxiety symptoms and an high inverse correlation between the character dimension of Self-Directedness and anxiety symptoms. Moreover specific anxiety disorders has showed typical correlation with specific temperamental and character traits. The comparison between the longitudinal studies argues in favor of a “precursor model” of explanation of these correlations whereby personality can be used to individuate early manifestations of anxiety disorder

Clinical Psychology of Oral Health: The Link Between Teeth and Emotions:

The effects of oral health conditions on physical and psychosocial dimensions have been a matter of interest for several authors over the last decades. Nevertheless, literature lacks studies that address the relationship between the oral health–related quality of life (OHRQoL) and emotions. The present study aimed to investigate the psychological impact of oral disorders on people's emotional well-being, with a particular attention to gender and age differences. Two hundred twenty-nine dental patients in care at private dental clinics were individually tested. One hundred thirty of them were females (56.8%) and 99 males (43.2%), aged between 18 and 83 years ( M = 38.11; SD = 16.7). For the evaluation, the Profile of Mood States (POMS) and the Oral Health Impact Profile (OHIP-14) were used. Data were analyzed using Pearson's correlations, the ANOVA, and the Kruskal–Wallis test. OHRQoL showed several correlations with all the emotions explored, overcoming the well-known relationship with anxiety and depression ( p < .05). The degree of OHRQoL produced differences on mood states, which could appear normal, moderately altered, or psychopathological ( p < .03). Furthermore, in different life stages, patients showed specific OHRQoL and emotions

Legislative and ethical aspects on use of canine artificial insemination in the 21st century

n/

Modeling Resilience of Collaborative AI Systems

A Collaborative Artificial Intelligence System (CAIS) performs actions in collaboration with the human to achieve a common goal. CAISs can use a trained AI model to control human-system interaction, or they can use human interaction to dynamically learn from humans in an online fashion. In online learning with human feedback, the AI model evolves by monitoring human interaction through the system sensors in the learning state, and actuates the autonomous components of the CAIS based on the learning in the operational state. Therefore, any disruptive event affecting these sensors may affect the AI model's ability to make accurate decisions and degrade the CAIS performance. Consequently, it is of paramount importance for CAIS managers to be able to automatically track the system performance to understand the resilience of the CAIS upon such disruptive events. In this paper, we provide a new framework to model CAIS performance when the system experiences a disruptive event. With our framework, we introduce a model of performance evolution of CAIS. The model is equipped with a set of measures that aim to support CAIS managers in the decision process to achieve the required resilience of the system. We tested our framework on a real-world case study of a robot collaborating online with the human, when the system is experiencing a disruptive event. The case study shows that our framework can be adopted in CAIS and integrated into the online execution of the CAIS activities.Comment: This paper is accepted at the 3rd International Conference on AI Engineering - Software Engineering for AI (CAIN 2024), Lisbon, Portuga

Puppy growth rate during early periods of labrador retriever development: role of litter size and photoperiod of birth

Several studies have recently investigated the birth weight of puppies from different pure-bred dogs. In general, birth weight decreased with litter size but there has been limited investigation into factors influencing growth during early development. The first month of life includes three stages of puppy development: neonatal (0–13 days), transitional (14–20 days), and first week of socialisation period (21–28 days). The aim of this study was to evaluate bodyweight and growth rate of 120 Labrador Retriever (LR) puppies during early development. Puppies from 19 show-line bitches under standardised composition of diet during pregnancy and lactation were involved in this study. Puppies were weighed weekly from birth to 28 days using an electronic digital balance. Relative weight gain (ΔW) was calculated for the neonatal period [ΔW1 = (Wday14-Wday0)/Wday0], transition period [ΔW2 = (Wday21-Wday14)/Wday14] and first week of socialisation period [ΔW2 = (Wday28-Wday21)/Wday21]. The effects of covariates on ΔW were assessed using generalised linear mixed models. Sex and photoperiod had no impact on relative weight gain, whereas litter size had a significant effect at ΔW1 (p < .01) but not at ΔW2 and at ΔW3. Relative weight gain was slightly lower in puppies from larger litter born during short photoperiod on ΔW1. A deeper knowledge of the factors that significantly influence weight gain during the first four weeks of life could be useful for physiological and behavioural science as well as for canine breeding management.Highlights 120 Labrador Retriever puppies were weighed weekly from birth to 28 days using an electronic digital balance. Relative weight gain (ΔW) was calculated for the neonatal period (ΔW1), transition period (ΔW2) and first week of socialisation period (ΔW3). Litter size had a significant effect on relative weight gain at ΔW1 but not at ΔW2 and ΔW3. Relative weight gain was slightly lower in puppies from larger litter born during short photoperiod on ΔW1

HP-LT metamorphism in Elba Island: Implications for the geodynamic evolution of the inner Northern Apennines (Italy)

The inner Northern Apennines belt (i.e., northern Tyrrhenian Sea and Tuscany) is an Alpine chain affectedby high-P metamorphic conditions during its evolution. Although Elba Island is structurally located closeto the Adria-Europe suture zone, for several authors it represents a sector of the orogen affected bylow-P metamorphism. The involvement of Elba Island tectonic units in high-P metamorphism was onlysuspected for the sparse presence of phengitic white mica in the metasedimentary rocks. This paperpresents the first clear evidence of high-P and low-T metamorphism found in metabasite rocks embed-ded in the Cretaceous calcschist of eastern Elba Island. Mineral composition of metabasite includesGln + Cpx + Ep + Ab + Act + Qtz + Ilm ± Ti-oxide ± Spn and is indicative of a former equilibration in the epi-dote blueschist subfacies and subsequent retrogression in the greenschist facies. Recorded metamorphicconditions are P = 0.9–1.0 GPa and T = 330–350◦C. Tectonic discrimination using immobile elements inthe metabasite does not point to an oceanic setting. As a consequence, the metasedimentary succes-sion containing metabasite is explained as belonging to the Tuscan continental domain and not to theLigurian-Piedmont Ocean, as previously interpreted. Our results have two significant implications: (i)it is confirmed and strengthened that the tectonic stacking of the Elba Island units did not occur in alow-pressure context; (ii) Elba Island is now completely reconciled in the tectonic and metamorphicevolution of the inner Northern Apennines

Correlation between sperm parameters and circulating thyroid hormones and testosterone concentrations in Labrador Retriever dog

Thyroid hormones physiologically regulate the semen quality, by altering testosterone concentrations, and different seminal parameters, as well as sperm motility, viability and semen volume. Serum thyroxine (T4), free thyroxine (fT4), thyroid-stimulating hormone (TSH) and testosterone (T) concentrations were measured in 26 adult Labrador Retriever dogs (n. 20 normospermic and n. 6 azoospermic groups), aged 3 ± 0.5 years old, to determine their specific references, by taking into account the related conventional and kinematic sperm parameters and clinical ultrasound evaluations. The mean values of T4, fT4, TSH and T concentrations, as soon as those of sperm parameters and clinical evaluations of normospermic group were in line with dog's physiological range of literature data. Normospermic group showed significant correlations between T4 and T (r = −0.681; p < .01), sperm progressive motility (%) (r = −0.623; p < .01), and sperm non-progressive motility (%) (r = 0.625; p < .02). The azoospermic group showed higher T4, fT4, TSH and lower T concentrations, compared to normospermic group, and a positive correlation between T4 and T (r = 0.8548; p < .046). The use of breed-specific hormonal ranges and sperm parameters will improve the knowledge of their interaction in Labrador Retriever dogs, adding a new segment of scientific literature.Highlights Thyroxine (T4), free thyroxine (fT4), thyroid stimulating hormone (TSH) and testosterone (T) concentrations were measured in male dogs. Conventional and kinematic sperm parameters were also evaluated. Dogs were divided in 20 normospermic and n. 6 azoospermic Labrador Retrivers. Azoospermic group showed higher values of T4, fT4, TSH and lower values of T compared to normospermic Use of breed-specific hormonal ranges and sperm parameters will improve the knowledge of scientific literature

In ricordo di Alfredo De Paz

Nel corso di una lunga attività critica orientata allo studio e alla comprensione dell’arte contemporanea e delle sue dinamiche, lo studioso Alfredo De Paz ha saputo adoperare e coniugare metodologie che vanno dalla sociologia alla culturologia, dal purovisibilismo alla massmediologia, applicandole a un raggio di argomenti amplissimo che va dal Romanticismo alle Avanguardie storiche. Si è quindi avvertita la necessità di ricordare, sintetizzare e rimeditare le sue riflessioni e i suoi contributi, senza trascurare tuttavia la qualità umana della sua persona. Negli interventi dei suoi ex-colleghi, qui riuniti, riaffiorano grandi figure della cultura del nostro tempo: il Loos di Ornamento e delitto, il Wölfflin dei Concetti fondamentali della storia dell’arte, l’Hauser della Storia sociale dell’arte, il McLuhan de Gli strumenti del comunicare. Si tratta solo di alcuni tra i principali autori assorbiti e sapientemente rielaborati da Alfredo De Paz lungo oltre quarant’anni di studi e ricerche, per cogliere al meglio la natura profonda e molteplice dell’arte del nostro tempo

Clinical and Molecular-Based Approach in the Evaluation of Hepatocellular Carcinoma Recurrence after Radical Liver Resection

Background: Hepatic resection remains the treatment of choice for patients with early-stage HCC with preserved liver function. Unfortunately, however, the majority of patients develop tumor recurrence. While several clinical factors were found to be associated with tumor recurrence, HCC pathogenesis is a complex process of accumulation of somatic genomic alterations, which leads to a huge molecular heterogeneity that has not been completely understood. The aim of this study is to complement potentially predictive clinical and pathological factors with next-generation sequencing genomic profiling and loss of heterozygosity analysis. Methods: 124 HCC patients, who underwent a primary hepatic resection from January 2016 to December 2019, were recruited for this study. Next-generation sequencing (NGS) analysis and allelic imbalance assessment in a case-control subgroup analysis were performed. A time-to-recurrence analysis was performed as well by means of Kaplan-Meier estimators. Results: Cumulative number of HCC recurrences were 26 (21%) and 32 (26%), respectively, one and two years after surgery. Kaplan-Meier estimates for the probability of recurrence amounted to 37% (95% C.I.: 24-47) and to 51% (95% C.I.: 35-62), after one and two years, respectively. Multivariable analysis identified as independent predictors of HCC recurrence: hepatitis C virus (HCV) infection (HR: 1.96, 95%C.I.: 0.91-4.24, p = 0.085), serum bilirubin levels (HR: 5.32, 95%C.I.: 2.07-13.69, p = 0.001), number of nodules (HR: 1.63, 95%C.I.: 1.12-2.38, p = 0.011) and size of the larger nodule (HR: 1.11, 95%C.I.: 1.03-1.18, p = 0.004). Time-to-recurrence analysis showed that loss of heterozygosity in the PTEN loci (involved in the PI3K/AKT/mTOR signaling pathway) was significantly associated with a lower risk of HCC recurrence (HR: 0.35, 95%C.I.: 0.13-0.93, p = 0.036). Conclusions: multiple alterations of cancer genes are associated with HCC progression. In particular, the evidence of a specific AI mutation presented in 20 patients seemed to have a protective effect on the risk of HCC recurrence

Liver Transplantation for Unresectable Intrahepatic Cholangiocarcinoma: The Role of Sequencing Genetic Profiling

: Intrahepatic cholangiocarcinoma (iCCA) is a rare and aggressive primary liver tumor, characterized by a range of different clinical manifestations and by increasing incidence and mortality rates even after curative treatment with radical resection. In recent years, growing attention has been devoted to this disease and some evidence supports liver transplantation (LT) as an appropriate treatment for intrahepatic cholangiocarcinoma; evolving work has also provided a framework for better understanding the genetic basis of this cancer. The aim of this study was to provide a clinical description of our series of patients complemented with Next-Generation Sequencing genomic profiling. From 1999 to 2021, 12 patients who underwent LT with either iCCA or a combined hepatocellular and cholangiocellular carcinoma (HCC-iCCA) were included in this study. Mutations were observed in gene activating signaling pathways known to be involved with iCCA tumorigenesis (KRAS/MAPK, P53, PI3K-Akt/mTOR, cAMP, WNT, epigenetic regulation and chromatin remodeling). Among several others, a strong association was observed between the Notch pathway and tumor size (point-biserial rhopb = 0.93). Our results are suggestive of the benefit potentially derived from molecular analysis to improve our diagnostic capabilities and to devise new treatment protocols, and eventually ameliorate long-term survival of patients affected by iCCA or HCC-iCCA