3-hexen-1-ol isomers in Müller-Thurgau wines: A ''varietal'' characteristic affected by must sulfiting time

Research NoteMust sulfiting time can be responsible for differences in the (3E)/(3Z)-hexen-1-ol ratio of wines produced on a semi-industrial and industrial scale. However, as the (3E) isomer is normally higher than the (32) isomer, the ratio could be used, with some caution, as a contributing parameter to verifying the varietal origin of some wines, in particular of Müller-Thurgau. After hexanol, (3E)-hexen-1-ol seems to be the main Cb-alcohol in Müller-Thurgau wines from Trentino (Italy)

Bartlett pear unsaturated ethyl deconoates and C9 compounds among components characterizing cv. Catalan roxo grape marc distillates

Catalan roxo marc distillates contain compounds at an unusual level in a grape derivate. The most peculiar are several unsaturated ethyl decanoates typical of Bartlett pear distillates and derived from ethyl esters found in the grape skins, some of which partially modified in the stereoisomery probably by the fermentation process. Remarkable compounds are unbranched aliphatic C-9 compounds at different oxidation state as well as ethyl nonanoate. At sensorially interesting levels methyl and ethyl salicylate and ethyl cinnamate, monoterpenols typical of floral-like varieties, vitispiranes and 4-ethylguaiacol are detected. Methyl salicylate is found in the berry as free and bound compound as several monoterpenols

Evaluation of building envelope retrofit techniques for reducing energy needs for space cooling.

One of the fastest growing sources of new energy demand is space cooling. According to EU-studies a four-fold growth in air-conditioned space is likely to take place between 1990 and 2020. The energy savings achievable in the end-use space cooling depend on a number of variables related to the building envelope, the plants and to some extent the behaviour of occupants. They are hence complex to evaluate and consequently often underrepresented in energy efficiency programmes and National Plans. This paper is based on some preliminary results of the IEE project KeepCool 2. It discusses in particular: a methodology for bottom-up assessment of the energy savings related to "sustainable summer comfort" solutions; reference base case building typologies are analyzed in 5 European climates, and dynamic simulations are used to calculate the reductions in the energy need for cooling which can be achieved by specific retrofit actions (e.g. additions of effective solar protections, increased thermal insulation, night ventilation, increase of active mass by PCM, low solar absorbance surfaces,...); situations where mechanical cooling can be avoided are evaluated using the Adaptive Comfort model, according to the norm EN 15251. case studies of buildings with good summer comfort and low energy consumption performances, according to the ten steps of the KC2 procedure. the analysis of case studies of "comfort policies" adopted by public and private bodies to ensure summer comfort with low energy consumption (commitments to give priority to heat load reductions instead of introducing mechanical cooling, relaxed dress codes, low thermal insulation chairs, local air velocity increase)

Supramolecular Assemblies in Silver Complexes: Phase Transitions and the Role of the Halogen Bond

Weak interactions (hydrogen bonds, halogen bonds, CH···πand Ï€-πstacking) can play a significant role in the formation of supramolecular assemblies with desired structural features. In this contribution, we report a systematic investigation on how a halogen bond (XB) can modulate the structural arrangement of silver supramolecular complexes. The complexes are composed of X-phenyl(bispyrazolyl)methane (X = Br, I) and I-alkynophenyl(bispyrazolyl)methane ligands functionalized in meta (L3Br, L3I) and para (L4Br, L4I, L4CCI) positions on a phenyl ring with the purpose of providing different directionalities of the X function with respect to the N,N coordination system. The obtained [Ag(L)2]+ moieties show remarkable geometric similarities, and the L4Br, L4I, and L4CCI ligands exhibit the most conserved types of supramolecular arrangement that are sustained by XB. The increased σ-hole in L4CCI with respect to L4I leads to an occurrence of short (and strong) XB interactions with the anions. [Ag(L4I)2]PF6 and [Ag(L4I)2]CF3SO3 are characterized by the presence of three different phases, and the single-crystal evolution from phase-1 (a honeycomb structure with large 1D cavities) to phase-3 (solventless) occurs by a stepwise decrease in the crystallization solvent content, which promotes an increase in XB interactions in the lattice. The present paper aims to provide useful tools for the selection of appropriate components for the use of coordination compounds to build supramolecular systems based on the halogen bond

Phosphine Oxide Porous Organic Polymers Incorporating Cobalt(II) Ions: Synthesis, Characterization, and Investigation of H2Production

Suitably functionalized porous matrices represent versatile platforms to support well-dispersed catalytic centers. In the present study, porous organic polymers (POPs) containing phosphine oxide groups were fabricated to bind transition metals and to be investigated for potential electrocatalytic applications. Cross-linking of mono- and di-phosphine monomers with multiple phenyl substituents was subject to the Friedel-Crafts (F-C) reaction and the oxidation process, which generated phosphine oxide porous polymers with pore capacity up to 0.92 cm3/g and a surface area of about 990 m2/g. The formation of the R3P·BH3 borohydride adduct during synthesis allows to extend the library of phosphine-based monomeric entities when using FeCl3. The porous polymers were loaded with 0.8-4.2 w/w % of cobalt(II) and behaved as hydrogen evolution reaction (HER) catalysts with a Faradaic efficiency of up to 95% (5.81 × 10-5 mol H2 per 11.76 C) and a stable current density during repeated controlled potential experiments (CPE), even though with high overpotentials (0.53-0.68 V to reach a current density of 1 mA·cm-2). These studies open the way to the effectiveness of tailored phosphine oxide POPs produced through an inexpensive and ecofriendly iron-based catalyst and for the insertion of transition metals in a porous architecture, enabling electrochemically driven activation of small molecules

Identification of TENM4 as a novel cancer stem cell-associated molecule and potential target in triple negative breast cancer

Triple-negative breast cancer (TNBC) is insensitive to endocrine and Her2-directed therapies, making the development of TNBC-targeted therapies an unmet medical need. Since patients with TNBC frequently show a quicker relapse and metastatic progression compared to other breast cancer subtypes, we hypothesized that cancer stem cells (CSC) could have a role in TNBC. To identify putative TNBC CSC-associated targets, we compared the gene expression profiles of CSC-enriched tumorspheres and their parental cells grown as monolayer. Among the up-regulated genes coding for cell membrane-associated proteins, we selected Teneurin 4 (TENM4), involved in cell differentiation and deregulated in tumors of different histotypes, as the object for this study. Meta-analysis of breast cancer datasets shows that TENM4 mRNA is up-regulated in invasive carcinoma specimens compared to normal breast and that high expression of TENM4 correlates with a shorter relapse-free survival in TNBC patients. TENM4 silencing in mammary cancer cells significantly impaired tumorsphere-forming ability, migratory capacity and Focal Adhesion Kinase (FAK) phosphorylation. Moreover, we found higher levels of TENM4 in plasma from tumor-bearing mice and TNBC patients compared to the healthy controls. Overall, our results indicate that TENM4 may act as a novel biomarker and target for the treatment of TNBC