Models of plastic depinning of driven disordered systems

Two classes of models of driven disordered systems that exhibit history-dependent dynamics are discussed. The first class incorporates local inertia in the dynamics via nonmonotonic stress transfer between adjacent degrees of freedom. The second class allows for proliferation of topological defects due to the interplay of strong disorder and drive. In mean field theory both models exhibit a tricritical point as a function of disorder strength. At weak disorder depinning is continuous and the sliding state is unique. At strong disorder depinning is discontinuous and hysteretic.Comment: 3 figures, invited talk at StatPhys 2

Driven depinning of strongly disordered media and anisotropic mean-field limits

Extended systems driven through strong disorder are modeled generically using coarse-grained degrees of freedom that interact elastically in the directions parallel to the driving force and that slip along at least one of the directions transverse to the motion. A realization of such a model is a collection of elastic channels with transverse viscous couplings. In the infinite range limit this model has a tricritical point separating a region where the depinning is continuous, in the universality class of elastic depinning, from a region where depinning is hysteretic. Many of the collective transport models discussed in the literature are special cases of the generic model.Comment: 4 pages, 2 figure

Plasticity in current-driven vortex lattices

We present a theoretical analysis of recent experiments on current-driven vortex dynamics in the Corbino disk geometry. This geometry introduces controlled spatial gradients in the driving force and allows the study of the onset of plasticity and tearing in clean vortex lattices. We describe plastic slip in terms of the stress-driven unbinding of dislocation pairs, which in turn contribute to the relaxation of the shear, yielding a nonlinear response. The steady state density of free dislocations induced by the applied stress is calculated as a function of the applied current and temperature. A criterion for the onset of plasticity at a radial location $r$ in the disk yields a temperature-dependent critical current that is in qualitative agreement with experiments.Comment: 11 pages, 4 figure

Mobility through Heterogeneous Networks in a 4G Environment

Serving and Managing users in a heterogeneous environment. 17th WWRF Meeting in Heidelberg, Germany, 15 - 17 November 2006. [Proceeding presented at WG3 - Co-operative and Ad-hoc Networks]The increase will of ubiquitous access of the users to the requested services points towards the integration of heterogeneous networks. In this sense, a user shall be able to access its services through different access technologies, such as WLAN, Wimax, UMTS and DVB technologies, from the same or different network operators, and to seamless move between different networks with active communications. In this paper we propose a mobility architecture able to support this users’ ubiquitous access and seamless movement, while simultaneously bringing a large flexibility to access network operators

5-Fluorouracil degradation rate as a predictive biomarker of toxicity in breast cancer patients treated with capecitabine

Capecitabine is an oral prodrug of 5-fluorouracil with a relevant role in the treatment of breast cancer. Severe and unexpected toxicities related to capecitabine are not rare, and the identification of biomarkers is challenging. We evaluate the relationship between dihydropyrimidine dehydrogenase, thymidylate synthase enhancer region and methylenetetrahydrofolate reductase polymorphisms, 5-fluorouracil degradation rate and the onset of G3–4 toxicities in breast cancer patients. Genetic polymorphisms and the 5-fluorouracil degradation rate of breast cancer patients treated with capecitabine were retrospectively studied. Genetic markers and the 5-fluorouracil degradation rate were correlated with the reported toxicities. Thirty-seven patients with a median age of 58 years old treated with capecitabine for stages II–IV breast cancer were included in this study. Overall, 34 (91.9%) patients suffered from at least an episode of any grade toxicity while nine patients had G3–4 toxicity. Homozygous methylenetetrahydrofolate reductase 677TT was found to be significantly related to haematological toxicity (OR = 6.5 [95% IC 1.1–37.5], P = 0.04). Three patients had a degradation rate less than 0.86 ng/mL/106 cells/min and three patients greater than 2.1 ng/mL/106 cells/min. At a univariate logistic regression analysis, an altered value of 5-fluorouracil degradation rate (values < 0.86 or >2.10 ng/mL/106 cells/min) increased the risk of G3–4 adverse events (OR = 10.40 [95% IC: 1.48–7.99], P = 0.02). A multivariate logistic regression analysis, adjusted for age, comorbidity and CAPE-regimen, confirmed the role of 5-fluorouracil degradation rate as a predictor of G3–4 toxicity occurrence (OR = 10.9 [95% IC 1.2–96.2], P = 0.03). The pre-treatment evaluation of 5-fluorouracil degradation rate allows to identify breast cancer patients at high risk for severe 5-FU toxicity

Tissue location of resistance in apple to the rosy apple aphid established by electrical penetration graphs

A study of the constitutive resistance of the apple cultivar Florina, Malus domestica Borkh. (Rosaceae), to the rosy apple aphid, Dysaphis plantaginea (Passerini) (Homoptera Aphididae), was performed for the first time by the electrical penetration graph (DC-EPG) system, using the susceptible apple cultivar Smoothe as control. All experiments were conducted with apterous adult virginoparae. The results showed a constitutive resistance in Florina due to a much longer period before the first probe reflecting surface factors. Some weak indications were found for pre-phloem resistance and initiating phloem access was not affected as inferred from equal time to show phloem salivation. However, the complete absence of phloem ingestion indicates a major resistance factor in the phloem sieve elements, most likely in the sieve element sap. Surface factors could have affected tissue related variables and this should be studied further. Anyhow, the strong constitutive resistance in Florina, either on the surface alone or in the phloem as well, effectively prevented reliable experiments on induced resistance, previously detected by molecular methods