RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Bright solitary matter waves: formation, stability and interactions.

In recent years, bright soliton-like structures composed of gaseous Bose-Einstein condensates have been generated at ultracold temperature. The experimental capacity to precisely engineer the nonlinearity and potential landscape experienced by these solitary waves offers an attractive platform for fundamental study of solitonic structures. The presence of three spatial dimensions and trapping implies that these are strictly distinct objects to the true soliton solutions. Working within the zero-temperature mean-field description, we explore the solutions and stability of bright solitary waves, as well as their interactions. Emphasis is placed on elucidating their similarities and differences to the true bright soliton. The rich behaviour introduced in the bright solitary waves includes the collapse instability and symmetry-breaking collisions. We review the experimental formation and observation of bright solitary matter waves to date, and compare to theoretical predictions. Finally we discuss the current state-of-the-art of this area, including beyond-mean-field descriptions, exotic bright solitary waves, and proposals to exploit bright solitary waves in interferometry and as surface probes.Comment: 40 pages, 14 figure

Stoechadone: A new naphthoquinone from conospermum stoechadis

Extraction of the dried root bark of the Western Australian plant Conospermum stoechadis Endl . has yielded 3,6,7-trimethoxy-2-methylnaphthalene-1,4-dione, stoechadone (1). The structure was elucidated by spectroscopic methods and was confirmed by a short synthesis from methyl homoveratrate (3)