941 research outputs found
Scattering by Interstellar Dust Grains. II. X-Rays
Scattering and absorption of X-rays by interstellar dust is calculated for a
model consisting of carbonaceous grains and amorphous silicate grains. The
calculations employ realistic dielectric functions with structure near X-ray
absorption edges, with resulting features in absorption, scattering, and
extinction.
Differential scattering cross sections are calculated for energies between
0.3 and 10 keV. The median scattering angle is given as a function of energy,
and simple but accurate approximations are found for the X-ray scattering
properties of the dust mixture, as well as for the angular distribution of the
scattered X-ray halo for dust with simple spatial distributions. Observational
estimates of the X-ray scattering optical depth are compared to model
predictions. Observations of X-ray halos to test interstellar dust grain models
are best carried out using extragalactic point sources.Comment: ApJ, accepted. 27 pages, 12 figures. Much of this material was
previously presented in astro-ph/0304060v1,v2,v3 but has been separated into
the present article following recommendation by the refere
The Fall and Rise of US Inequities in Premature Mortality: 1960–2002
Nancy Krieger and colleagues found evidence of decreasing, and then increasing or stagnating, socioeconomic and racial inequities in US premature mortality and infant death from 1960 to 2002
Lie point symmetries and first integrals: the Kowalevsky top
We show how the Lie group analysis method can be used in order to obtain
first integrals of any system of ordinary differential equations.
The method of reduction/increase of order developed by Nucci (J. Math. Phys.
37, 1772-1775 (1996)) is essential. Noether's theorem is neither necessary nor
considered. The most striking example we present is the relationship between
Lie group analysis and the famous first integral of the Kowalevski top.Comment: 23 page
Androgen Receptor Functional Analyses by High Throughput Imaging: Determination of Ligand, Cell Cycle, and Mutation-Specific Effects
Understanding how androgen receptor (AR) function is modulated by exposure to steroids, growth factors or small molecules can have important mechanistic implications for AR-related disease therapies (e.g., prostate cancer, androgen insensitivity syndrome, AIS), and in the analysis of environmental endocrine disruptors.We report the development of a high throughput (HT) image-based assay that quantifies AR subcellular and subnuclear distribution, and transcriptional reporter gene activity on a cell-by-cell basis. Furthermore, simultaneous analysis of DNA content allowed determination of cell cycle position and permitted the analysis of cell cycle dependent changes in AR function in unsynchronized cell populations. Assay quality for EC50 coefficients of variation were 5–24%, with Z' values reaching 0.91. This was achieved by the selective analysis of cells expressing physiological levels of AR, important because minor over-expression resulted in elevated nuclear speckling and decreased transcriptional reporter gene activity. A small screen of AR-binding ligands, including known agonists, antagonists, and endocrine disruptors, demonstrated that nuclear translocation and nuclear “speckling” were linked with transcriptional output, and specific ligands were noted to differentially affect measurements for wild type versus mutant AR, suggesting differing mechanisms of action. HT imaging of patient-derived AIS mutations demonstrated a proof-of-principle personalized medicine approach to rapidly identify ligands capable of restoring multiple AR functions.HT imaging-based multiplex screening will provide a rapid, systems-level analysis of compounds/RNAi that may differentially affect wild type AR or clinically relevant AR mutations
Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88
This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, grant numbers 11/15682-4, 12/02270-2, 15/18121-4), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Regenera INCT Process Grant 465656/2014-5). JL is funded by the NIH/NIDDK R01DK106210. GDB is funded by the Wellcome Trust and the MRC Centre for Medical Mycology. Open access journalPeer reviewedPublisher PD
Anomalous Pressure in Fluctuating Shear Flow
We investigate how the pressure in fluctuating shear flow depends on the
shear rate and on the system size by studying fluctuating hydrodynamics
under shear conditions. We derive anomalous forms of the pressure for two
limiting values of the dimensionless parameter , where
is the kinematic viscosity. In the case , the pressure is not an
intensive quantity because of the influence of the long-range spatial
correlations of momentum fluctuations. In the other limit , the
long-range correlations are suppressed at large distances, and the pressure is
intensive. In this case, however, there is the interesting effect that the
non-equilibrium correction to the pressure is proportional to , which
was previously obtained with the projection operator method [K. Kawasaki and J.
D. Gunton, Phys. Rev. {\bf A 8}, 2048, (1973)].Comment: Breakdown of the intensivity of pressure is emphasized. Fig.1 and
references added; accepted for publication as a Rapid Communication in Phys.
Rev.
RF MEMS ohmic switches for matrix configurations
Two different topologies of radio frequency micro-electro-mechanical system (RF MEMS) series ohmic switches (cantilever and clamped–clamped beams) in coplanar waveguide (CPW) configuration have been characterized by means of DC, environmental, and RF measurements. In particular, on-wafer checks have been followed by RF test after vibration, thermal shocks, and temperature cycles. The devices have been manufactured on high resistivity silicon substrates, as building blocks to be implemented in different single-pole 4-throw (SP4 T), double-pole double-throw (DPDT) configurations, and then integrated in Low Temperature Co-fired Ceramics (LTCC) technology for the realization of large-order Clos 3D networks
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