The effect of median nerve mobilization on two point discrimination

[Purpose] Two-point discrimination (TPD) is expressed as the minimum distance at which two mechanical stimuli applied simultaneously to the skin can be perceived as two separate points. The aim of this study was to investigate the effect of median nerve mobilization on TPD in healthy adults. [Participants and Methods] This study included 120 healthy adults. Participants were randomized according to their gender into the Neural Mobilization Group (NMG) and Control Group (CG). Demographic data of the participants (gender, age, height, weight, BMI, smoking) were recorded and TPD measurement was performed with baseline aesthesiometer on the palm with distal phalanges of the thumb, index and middle finger on the right-left hand. After the baseline TPD test, participants in the NMG performed Median Nerve Mobilization for 14 days. Measurements were taken before and after training. [Results] A statistically significant difference was found in all other measurements in both groups, except for the right and left palm TPD measurements in the control group. [Conclusion] It is thought that it would be beneficial to investigate the healing effects of the neural mobilization applications, which include all parts of the nerve line in disease conditions

Специфика организации транспортной службы предприятия

В данной статье были рассмотрены проблемы организации транспортной службы предприятия. Актуальность темы исследования обусловлена, тем, что любую готовую продукцию необходимо транспортировать, в связи с этим были рассмотрены общие характеристики транспортной службы предприятия, сделаны выводы, позволяющие повысить эффективность работы транспортного цеха предприятия за счет повышения качества надежности внешних и внутрипроизводственных перевозок, что обеспечит повышение конкурентоспособности предприятия в целом

Proconvulsant effect of papaverine on penicillin-induced epileptiform activity in rats

WOS: 000435231900022PubMed ID: 28944941AIM: Papaverine is a vasodilator agent that is an opium alkaloid. It exhibits its effects by inhibiting the phosphodiesterase enzyme. Papaverine administration is widely used to avoid symptomatic vasospasm after subarachnoid hemorrhage. We aimed, in this research, to study the effects of papaverine on the epileptic discharges stimulated by penicillin. MATERIAL and METHODS: Adult female Wistar rats (220 +/- 30 g) were included in this research (n= 30). Rats were anesthetized with urethane (1.25 g/kg) and then the left cerebral cortex was reached by opening a burr hole with a drill. Penicillin G sodium salt (500 IU)(200 IU/1 mu l) was injected into the left lateral ventricle to produce epileptiform activity. Thirty minutes before penicillin G sodium injection, papaverine was administered at doses of 5, 10, 20 or 40 mg/kg intraperitoneally. RESULTS: There was no significant difference in spike frequency between the control group and the groups given 5 mg/kg, 10 mg/kg or 40 mg/kg papaverine, while 20 mg/kg papaverine significantly increased the spike frequency (p<0.05). CONCLUSION: Papaverine augments the epileptiform activity produced by penicillin injection. It is important to remember that papaverine might induce convulsions in patients who have epilepsy. More research is required to understand the mechanisms of the proconvulsant influence of papaverine in epilepsy

Further Evidence for the Role of Nitric Oxide in Maternal Aggression: Effects of L-NAME on Maternal Aggression towards Female Intruders in Wistar Rats

Ankarali, Seyit/0000-0003-3752-0846; Ankarali, Handan Camdeviren/0000-0002-3613-0523WOS: 000270857000015PubMed: 18657004It has been shown that nitric oxide (NO) increases aggression in male mice, whereas it decreases aggression in lactating female mice and prairie voles. It is also known that aggression can be exhibited at different levels in rodent species, strain or subtypes. The aims of this study were to investigate the proportion of aggressiveness in Wistar rats, the effect of intraperitoneally administered nonspecific nitric oxide synthase (NOS) inhibitor L-NAME (N-G-nitro L-arginine methyl ester) on maternal aggression towards female intruders, and whether these effects are due to NO production or not. Rats were given saline intraperitoneally on the postpartum Day 2 and aggression levels were recorded. The same rats were given 60 mg/kg L-NAME or D-NAME (N-G-nitro D-arginine methyl ester) on the postpartum Day 3 and their effects on aggression levels were compared to saline. While L-NAME administration did not cause any differences in the total number of aggressive behavior, aggression duration and aggression intensity, it reduced the proportion of animals showing aggressive behavior. In addition, the latency of the first aggression was significantly increased by L-NAME. In the D-NAME group, however, no significant change was found. Our results have shown that L-NAME reduces maternal aggression towards female intruders in Wistar rats through inhibition of NO production. These results suggest that the role of NO in offensive and defensive maternal aggression shares neural mechanisms

The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats

AYYILDIZ, Mustafa/0000-0002-6594-3080; Ankarali, Seyit/0000-0003-3752-0846; Yildirim, Mehmet/0000-0003-1798-5478WOS: 000293206400003PubMed: 21731075In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 mu g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 mu g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 mu g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 mu g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine.Committee for Scientific Research of Ondokuz Mayis UniversityOndokuz Mayis University [T235, T389]The authors would like to thank Prof Dr Yuksel Bek for the statistical analysis and Dr Leslie Scarth for help in polishing the English. This study was supported by the Committee for Scientific Research of Ondokuz Mayis University (Grant no: T235 and T389)

Assesment of Superior Colliculus in Audiogenic Epilepsy-Prone Wistar Rats Using A Stereological Method

Objectives:Audiogenic seizures are generated in the brainstem and involve the inferior and superior colliculi in their expression. Aim of the present study was to estimate total number of neurons in the right and left superior colliculi in genetically audiogenic epilepsy-prone Wistar rats using stereological method.Methods:Ten female Wistar rats, weighing 180 to 220 g each, were divided into 2 groups: control (n=5) and audiogenic epilepsy (n=5) groups. Subjects were anesthetized with urethane (1.25 g/kg, intraperitoneal) and 10% formalin was perfused through the left cardiac ventricle. Total number of neurons was estimated in the right and left superior colliculi in both groups using optical fractionator stereological method.Results:Total number of neurons in the superior colliculi was statistically lower in the right side of group with epilepsy compared with same side of control group (p<0.05). There was also a significant difference between right and left sides in the epilepsy group (p<0.05).Conclusion:It has been determined that cellular mechanisms have a significant role in audiogenic epilepsy. The fact that there were significantly fewer neurons in right superior colliculus of epilepsy group compared with control group suggests that this area is likely to be influential on triggering the onset of seizure activity

Research university ıdentity, quality problems in phd and residency education and search of contemporary university in Turkey

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Research University Identity, Quality Problems in PhD and Residency Education and Search of Contemporary University in Turkey

WOS: 000383578300020

Protective effects of melatonin and omega-3 on the hippocampus and the cerebellum of adult Wistar albino rats exposed to electromagnetic fields

The purpose of the study was to investigate the effects of pulsed digital electromagnetic radiation emitted by mobile phones on the central nervous system of the adult Wistar albino rats. The study evaluated structural and functional impacts of four treatment arms: electromagnetic field (EMF) exposed; EMF exposed + melatonin treated group (EMF + Mel); EMF exposed + omega-3 (ω3) treated group (EMF + ω3); and control group (Cont). The 12-weeks-old rats were exposed to 900 MHz EMF for 60 min/day (4:00–5:00 p.m.) for 15 days. Stereological, biochemical and electrophysiological techniques were applied to evaluate protective effects of Mel and ω3. Significant cell loss in the CA1 and CA2 regions of hippocampus were observed in the EMF compared to other groups (p 0.05). The passive avoidance test showed that entrance latency into the dark compartment was significantly shorter in the EMF (p < 0.05). Additionally, EMF had a higher serum enzyme activity than the other groups (p < 0.01). In conclusion, our analyses confirm that EMF may lead to cellular damage in the hippocampus and the cerebellum, and that Mel and ω3 may have neuroprotective effects

Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: Association with neuroprotection of pyramidal cells

WOS: 000427664300005PubMed ID: 29126816The aim of this study is to investigate the effects of spermine and the passive avoidance learning on hippocampus following transient cerebral ischemia in the chicks. The study is composed of the pure control (CG), sham (SG) and experimental groups (n = 20). Experimental groups (ischemia group, IG and ischemia-spermine group, ISG) were exposed to ischemia for 20 min whereas the SG was exposed to sham operation and CG group was not exposed to any operation. Passive avoidance learning (PAL) was applied to the half number of the subjects in each group. Both before and after 7 days from the ischemia, operated animals were taken to PAL and then they were sacrificed. Total numbers of neurons in the hippocampus were stereologically estimated using Cresyl violet stained sections. We detected that number of neurons was increased following PAL and especially spermine treatment. According to our results, we suggested that spermine may reduce the deleterious effects of the ischemia by causing to increase in the neuronal number and so, it may be slightly supportive to the PAL.Ondokuz Mayis University [PYO. TIP. 1901.09.015]The Animal Ethics Committee of Yuzuncu Yil University approved the protocol and appropriate measures were taken to minimize pain or discomfort of the animals by our study group. The experimental part of this study and stereological examination was performed at Ondokuz Mayis University, Department of Histology and Embryology. This study was supported by Ondokuz Mayis University, (PYO. TIP. 1901.09.015)