4 research outputs found
The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury : data from the European Prospective Investigation into Cancer and Nutrition
Background: Higher coffee intake has been purportedly related to a lower risk of liver cancer. However, it remains unclear whether this association may be accounted for by specific biological mechanisms. Objective: We aimed to evaluate the potential mediating roles of inflammatory, metabolic, liver injury, and iron metabolism biomarkers on the association between coffee intake and the primary form of liver cancer-hepatocellular carcinoma (HCC). Design: We conducted a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition among 125 incident HCC cases matched to 250 controls using an incidence-density sampling procedure. The association of coffee intake with HCC risk was evaluated by using multivariable-adjusted conditional logistic regression that accounted for smoking, alcohol consumption, hepatitis infection, and other established liver cancer risk factors. The mediating effects of 21 biomarkers were evaluated on the basis of percentage changes and associated 95% CIs in the estimated regression coefficients of models with and without adjustment for biomarkers individually and in combination. Results: The multivariable-adjusted RR of having >= 4 cups (600mL) coffee/d compared with <2 cups (300 mL)/d was 0.25 (95% CI: 0.11, 0.62; P-trend = 0.006). A statistically significant attenuation of the association between coffee intake and HCC risk and thereby suspected mediation was confirmed for the inflammatory biomarker IL-6 and for the biomarkers of hepatocellular injury glutamate dehydrogenase, alanine aminotransferase, aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), and total bilirubin, which-in combination-attenuated the regression coefficients by 72% (95% CI: 7%, 239%). Of the investigated biomarkers, IL-6, AST, and GGT produced the highest change in the regression coefficients: 40%, 56%, and 60%, respectively. Conclusion: These data suggest that the inverse association of coffee intake with HCC risk was partly accounted for by biomarkers of inflammation and hepatocellular injury
The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition
Background: Higher coffee intake has been purportedly related to a lower
risk of liver cancer. However, it remains unclear whether this
association may be accounted for by specific biological mechanisms.
Objective: We aimed to evaluate the potential mediating roles of
inflammatory, metabolic, liver injury, and iron metabolism biomarkers on
the association between coffee intake and the primary form of liver
cancer-hepatocellular carcinoma (HCC).
Design: We conducted a prospective nested case-control study within the
European Prospective Investigation into Cancer and Nutrition among 125
incident HCC cases matched to 250 controls using an incidence-density
sampling procedure. The association of coffee intake with HCC risk was
evaluated by using multivariable-adjusted conditional logistic
regression that accounted for smoking, alcohol consumption, hepatitis
infection, and other established liver cancer risk factors. The
mediating effects of 21 biomarkers were evaluated on the basis of
percentage changes and associated 95% CIs in the estimated regression
coefficients of models with and without adjustment for biomarkers
individually and in combination.
Results: The multivariable-adjusted RR of having >= 4 cups (600mL)
coffee/d compared with <2 cups (300 mL)/d was 0.25 (95% CI: 0.11, 0.62;
P-trend = 0.006). A statistically significant attenuation of the
association between coffee intake and HCC risk and thereby suspected
mediation was confirmed for the inflammatory biomarker IL-6 and for the
biomarkers of hepatocellular injury glutamate dehydrogenase, alanine
aminotransferase, aspartate aminotransferase (AST),
gamma-glutamyltransferase (GGT), and total bilirubin, which-in
combination-attenuated the regression coefficients by 72% (95% CI:
7%, 239%). Of the investigated biomarkers, IL-6, AST, and GGT produced
the highest change in the regression coefficients: 40%, 56%, and 60%,
respectively.
Conclusion: These data suggest that the inverse association of coffee
intake with HCC risk was partly accounted for by biomarkers of
inflammation and hepatocellular injury