Sandia Laboratories in-house activities in support of solar thermal large power applications

The development of thermal energy storage subsystems for solar thermal large power applications is described. The emphasis is on characterizing the behavior of molten nitrate salts with regard to thermal decomposition, environmental interactions, and corrosion. Electrochemical techniques to determine the ionic species in the melt and for use in real time studies of corrosion are also briefly discussed

Research on the exploitation of advanced composite materials to lightly loaded structures

The objective was to create a sailplane which could fly in weaker thermals than present day sailplanes (by being lighter) and to fly in stronger thermals than present sailplanes (by carrying more water ballast). The research was to tackle the interaction of advanced composites and the aerodynamic performance, the interaction of fabrication procedures and the advanced composites, and the interaction of advanced composites and the design process. Many pieces of the overall system were investigated but none were carried to the resolution required for engineering application. Nonetheless, interesting and useful results were obtained and are here reported

Determining the regimes of cold and warm inflation in the susy hybrid model

The SUSY hybrid inflation model is found to dissipate radiation during the inflationary period. Analysis is made of parameter regimes in which these dissipative effects are significant. The scalar spectral index, its running, and the tensor-scalar ratio are computed in the entire parameter range of the model. A clear prediction for strong dissipative warm inflation is found for n_S-1 \simeq 0.98 and a low tensor-scalar ratio much below 10^{-6}. The strong dissipative warm inflation regime also is found to have no \eta-problem and with the field amplitude much below the Planck scale. As will be discussed, this has important theoretical implications in permitting a much wider variety of SUGRA extensions to the basic model.Comment: paragraph added at the end of section V; references added; accepted for publication in Phys. Rev.

JAK2 Inhibition: Reviewing a New Therapeutical Option in Myeloproliferative Neoplasms

JAK2 is a tyrosine kinase gene that plays an essential role in the development of normal haematopoiesis. Hyperactivation of JAK2 occurs in myeloproliferative neoplasms by different mechanisms. As a consequence, JAK2 inhibitors have been designed to suppress the cytokine signalling cascade caused by the constitutive activation of JAK2. In clinical trials, JAK2 inhibitors are efficient in decreasing spleen size, controlling clinical symptoms, and improving quality of life in patients with myeloproliferative neoplasms. However, JAK2 inhibitors are unable to target uncommitted hematopoietic progenitors responsible of the initiation of the myeloproliferative disease. It is expected that, in order to cure the myeloproliferative disease, JAK2 inhibitors should be combined with other drugs to target simultaneously different pathways and to target the initiator hematopoietic cell population in myeloproliferative disorders. Taking advantage of the inhibition of the cytokine cascade of JAK2 inhibitors, these compounds are going to be used not only to treat patients with hematological neoplasms but may also be beneficial to treat patients with rheumatoid arthritis or other inflammatory diseases

Young learners' bilingual status and cognitive development in foreign language aptitude testing

Young learners' L1s preference, cognitive development and bilingual status might influence their performance on language aptitude tests, particularly if these are language-dependent. The objective of this study was to test the validity, reliability and consistency across populations of two such tests: the Modern Language Aptitude Test-Elementary in Catalan (MLAT-EC) and in Spanish (MLAT-ES). 629 bilingual students from grades 3 to 7 took the MLAT-ES and the MLAT-EC for test comparison in a counterbalanced order. The results show that their performance on both tests presented hardly any significant differences considering students' L1 preference (Catalan, Spanish or no preference). In addition, these bilingual examinees outperformed the predominantly monolingual samples in the MLAT-ES norming study. The same score patterns related to young learner cognitive development stages were found across test versions. These results reinforce the confidence in the validity of the MLAT-E adaptations and support the hypothesis that bilingualism results in greater aptitude