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Mesenchymal dental stem cells in regenerative dentistry
In the last decade, tissue engineering is a field that has been suffering an enormous expansion in the regenerative medicine and dentistry. The use of cells as mesenchymal dental stem cells of easy access for dentist and oral
surgeon, immunosuppressive properties, high proliferation and capacity to differentiate into odontoblasts, cementoblasts, osteoblasts and other cells implicated in the teeth, suppose a good perspective of future in the clinical
dentistry. However, is necessary advance in the known of growth factors and signalling molecules implicated
in tooth development and regeneration of different structures of teeth. Furthermore, these cells need a fabulous
scaffold that facility their integration, differentiation, matrix synthesis and promote multiple specific interactions
between cells.
In this review, we give a brief description of tooth development and anatomy, definition and classification of stem
cells, with special attention of mesenchymal stem cells, commonly used in the cellular therapy for their trasdifferentiation ability, non ethical problems and acceptable results in preliminary clinical trials.
In terms of tissue engineering, we provide an overview of different types of mesenchymal stem cells that have
been isolated from teeth, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous
teeth (SHEDs), periodontal ligament stem cells (PDLSCs), dental follicle progenitor stem cells (DFPCs), and stem
cells from apical papilla (SCAPs), growth factors implicated in regeneration teeth and types of scaffolds for dental
tissue regeneration