Improving the quality of publications in and advancing the paradigms of clinical and social pharmacy practice research: the Granada statements

Pharmacy and pharmaceutical sciences embrace a series of different disciplines. Pharmacy practice has been defined as ‘the scientific dis- cipline that studies the different aspects of the practice of pharmacy and its impact on health care systems, medicine use, and patient care’. Thus, pharmacy practice studies embrace both clinical pharmacy and social pharmacy elements. Like any other scientific discipline, clinical and social pharmacy practice disseminates research findings using scientific journals. Clinical pharmacy and social pharmacy journal editors have a role in promoting the discipline by enhancing the quality of the articles published. As has occurred in other healthcare areas (i.e. medicine and nursing), a group of clinical and social pharmacy practice journal editors gathered in Granada, Spain to discuss how journals could contribute to strengthening pharmacy practice as a discipline. The result of that meeting was compiled in these Granada Statements, which comprise 18 recommendations gathered into 6 topics, namely the appropriate use of terminology, impactful abstracts, the required peer reviews, journal scattering, more effective and wiser use of journal and article performance metrics and authors’ selection of the most appropriate pharmacy practice journal to submit their work

Letter from the Director

Estimados lectores de la revista ARS Pharmaceutica, Son ya más de 60 años desde que la revista ARS Pharmaceutica comenzó sus primeras publicaciones, y desde entonces el incremento en la calidad de los artículos así como la regularidad en sus publicaciones se ha mantenido como reto constante

Developing Project Managers’ Transversal Competences Using Building Information Modeling

The emergence of building information modeling (BIM) methodology requires the training of professionals with both specific and transversal skills. In this paper, a project-based learning experience carried out in the context of a project management course at the University of Extremadura is analyzed. To that end, a questionnaire was designed and given to students who participated in the initiative. Results suggest that BIM can be considered a virtual learning environment, from which students value the competences developed. The emotional performance observed was quite flat. Similarly, students valued the usefulness of the initiative. Students expressed a desire for the methodological change of the university classes, and thought that BIM methodology could be useful for other courses. The results obtained show a line of work to be done to improve the training of students and university teaching

Hydrothermal Synthesis of rGO-TiO2 Composites as High-Performance UV Photocatalysts for Ethylparaben Degradation

This work was supported by the Spanish Ministry of Economy, Industry and competitiveness and by FEDER (Project CTQ2016-80978-C2−1-R). M.R.-M. thanks to the Asociación Universitaria Iberoamericana de Postgrado (AUIP) and the University of Jaen for the grant awarded and the financial support.A series of reduced graphene oxide-TiO2 composites (rGO-TiO2) were prepared by hydrothermal treatment using graphite and titanium isopropoxide as raw materials. The structural, surface, electronic, and optical properties of the prepared composites were extensively characterized by N2 adsorption, FTIR, XRD, XPS, Raman spectroscopy, and DRS. GO was found to be effectively reduced and TiO2 to be in pure anatase phase in all composites obtained. Finally, experiments were performed to evaluate the effectiveness of these new materials as photocatalysts in the degradation of ethylparaben (EtP) by UV radiation. According to the band-gap energies obtained (ranging between 3.09 eV for 4% rGO-TiO2 to 2.55 eV for 30% rGO-TiO2), the rGO-TiO2 composites behave as semiconductor materials. The photocatalytic activity is highest with a rGO content of 7 wt % (7% rGO-TiO2), being higher than observed for pure TiO2 (Eg = 3.20 eV) and achieving 98.6% EtP degradation after only 40 min of treatment. However, the degradation yield decreases with higher percentages of rGO. Comparison with rGO-P25 composites showed that a better photocatalytic performance in EtP degradation is obtained with synthesized TiO2 (rGO-TiO2), probably due to the presence of the rutile phase (14.1 wt %) in commercial P25.Spanish Ministry of Economy, Industry and Competitiveness CTQ2016-80978-C2 1-REuropean Union (EU) CTQ2016-80978-C2 1-RAsociacion Universitaria Iberoamericana de Postgrado (AUIP)University of Jae

Erosion caused by propeller jets in a low energy harbour basin

This is an Accepted Manuscript of an article published by Taylor & Francis Group in Journal of Hydraulic Research on January, 2017, available online at: http://www.tandfonline.com/10.1080/00221686.2016.1252801Field data of a harbour basin are compared with analytical formulations for predicting maximum scouring depth due to propeller jets. Spatial data analysis of seven-year biannual bathymetries quantifies the evolution of the scouring hole along with the sedimentation process within a harbour basin. The maximum scouring depth is found to be of the order of the propeller diameter with a maximum scouring rate within the first six months of docking manoeuvring. Three of the analysed expressions yielded realistic results while observed discrepancies between the theoretical predictions and field data are related to scaling factors. The outcomes of this analysis can be extrapolated to other harbours to improve their management. The obtained results highlight the importance of field data in developing combined physical and numerical models.Peer ReviewedPostprint (author's final draft

Synthesis and Use of Silica Xerogels Doped with Iron as a Photocatalyst to Pharmaceuticals Degradation in Water

The main objective of this study was to assess the photoactive properties of iron-doped silica xerogels under solar radiation. For this purpose, silica xerogels (XGS) synthesized by the sol-gel method were doped with Fe (III) by two routes: impregnation and polymerization. XGS samples were texturally and chemically characterized by N2 adsorption, XRD, FTIR, Raman, SEM-EDX, DRS, and PL, evidencing the suitability of using XGS substrates to host iron clusters on their surface with total compatibility. Chlorphenamine (CPM), ciprofloxacin (CIP), and ranitidine (RNT) were used as model compounds. The degradation of the molecules was made under simulated solar radiation testing the synthesis pad, load, material size, and reuse. It was found that XGS doped with Fe by the impregnation route (XGS-Fe-Im) were able to completely degrade CPM and RNT in 30 min and 10 min, respectively, whilst for CIP it achieved the removal of 60% after 1 h of solar radiation exposure, outperforming parent materials and solar radiation by itself. The study of the degradation mechanism elucidated a major influence from the action of HO radicals. The present investigation offers a potential route of application of XGS Fe-doped materials for the removal of emerging concern contaminants under near real-world conditions.Junta de AndaluciaEuropean CommissionSpanish Government P18-RT-4193Consejo Nacional de Ciencia y Tecnologia (CONACyT) CVU 4921

Solar Degradation of Sulfamethazine Using rGO/Bi Composite Photocatalysts

This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness and by FEDER (CTQ2016-80978-C2−1-R), and the authors thank to Dr. Isabel Guerra Tschuschke for the technical advice during the VP-SEM study at the CIC-UGR.Heterogeneous photocatalysts for water decontamination were obtained by the optimized synthesis of bismuth-functionalized reduced graphene oxide (rGO/Bi) using the Hummer method and microwave treatment. Sulfamethazine (SMZ) was used as model pollutant to evaluate the photocatalytic efficacy. Photocatalysts were characterized by VP-SEM, HRTEM, XDR, XPS, RAMAN, and FTIR analyses, which confirmed the effective reduction of GO to rGO and the presence of bismuth as a crystalline phase of Bi2O3 polydispersed on the surface. Their performance was influenced by the rGO/Bi ratio, microwave temperature, and treatment time. The as-obtained 5%rGO/Bi composite had the highest photocatalytic activity for SMZ degradation under visible light irradiation (λ > 400 nm), achieving 100% degradation after only 2 h of treatment. The degradation yield decreased with higher percentages of rGO. Accordingly, the rGO/Bi catalysts efficiently removed SMZ, showing a high photocatalytic activity, and remained unchanged after three treatment cycles; furthermore, cytotoxicity tests demonstrated the nontoxicity of the aqueous medium after SMZ degradation. These findings support the potential value of these novel composites as photocatalysts to selectively remove pollutants in water treatment plants.Spanish Ministry of Economy, Industry and Competitiveness CTQ2016-80978-C2-1-REuropean Union (EU) CTQ2016-80978-C2-1-

Life Cycle Assessment of Cement Production with Marble Waste Sludges

The construction industry has a considerable environmental impact in societies, which must be controlled to achieve adequate sustainability levels. In particular, cement production contributes 5–8% of CO2 emissions worldwide, mainly from the utilization of clinker. This study applied Life Cycle Assessment (LCA) methodology to investigate the environmental impact of cement production and explore environmental improvements obtained by adding marble waste sludges in the manufacture of Portland cement. It was considered that 6–35% of the limestone required for its production could be supplied by marble waste sludge (mainly calcite), meeting the EN 197-1:2011 norm. Energy consumption and greenhouse gas (GHG) emission data were obtained from the Ecovent database using commercial LCA software. All life cycle impact assessment indicators were lower for the proposed “eco-cement” than for conventional cement, attributable to changes in the utilization of limestone and clinker. The most favorable results were achieved when marble waste sludge completely replaced limestone and was added to clinker at 35%. In comparison to conventional Portland cement production, this process reduced GHG emissions by 34%, the use of turbine waters by 60%, and the emission of particles into the atmosphere by 50%. Application of LCA methodology allowed evaluation of the environmental impact and improvements obtained with the production of a type of functional eco-cement. This approach is indispensable for evaluating the environmental benefits of using marble waste sludges in the production of cement.Junta de Andalucía and Fondo Europeo de Desarrollo Regional (FEDER) Ref. P18-RT-419

Comparative Study of the Oxidative Degradation of Different 4-Aminobenzene Sulfonamides in Aqueous Solution by Sulfite Activation in the Presence of Fe(0), Fe(II), Fe(III) or Fe(VI)

This study is focused on advanced oxidation technologies (AOTs) using the combined effect of Fe(0–VI)/sulfite systems, that produce mainly SO4 radicals, to remove di erent 4-aminobenzene sulfonamides (SAs), namely sulfamethazine, sulfadiazine, sulfamethizole, from aqueous solutions. Results obtained showed that neither sulfite nor iron alone is able to degrade SAs; however, the combined effect depends on the oxidation state of iron species whose effectiveness to activate sulfite to promote the degradation of SAs increased following this order: Fe(III) < Fe(II) < Fe(0) < Fe(VI). Using Fe(VI)/sulfite, the complete removal of SAs was obtained in 5 min largely surpassing the effectiveness of the other three systems. The sulfonamides’ removal percentage was markedly influenced by sulfite concentration and dissolved oxygen, which improved the generation of oxidant radicals. Response surface methodology was applied, and a quadratic polynomial model was obtained, which allowed us to determine the percentage of SAs degradation as a function of both the iron species and sulfite concentrations. The study of the influence of the water matrix on these AOTs revealed an inhibition of SAs’ removal percentage when using ground water. This is probably due to the presence of different anions, such as HCO3 -, Cl-, and SO4 2- in relatively high concentrations. According to the byproducts identified, the proposed degradation pathways include hydroxylation, SO2 extrusion, and different bond-cleavage processes. Cytotoxicity of degradation byproducts, using MTS assay with HEK 293 and J774 cell lines for the first time, did not show an inhibition in cell proliferation, sustaining the safety of the process.This research was funded by both Ministry of Science and Innovation of Spain, grant number CTQ2016-80978-C2-1-R, and CONACyT (Mexico), grant number 407494

Methotrexate Gold Nanocarriers: Loading and Release Study: Its Activity in Colon and Lung Cancer Cells

In the present study, the synthesis of gold nanoparticles (AuNPs) loaded with methotrexate (MTX) has been carried out in order to obtain controlled size and monodispersed nanocarriers of around 20 nm. The characterization study shows metallic AuNPs with MTX polydispersed on the surface. MTX is linked by the replacement of citrate by the MTX carboxyl group. The drug release profiles show faster MTX release when it is conjugated, which leads to the best control of plasma concentration. Moreover, the enhanced release observed at pH 5 could take advantage of the pH gradients that exist in tumor microenvironments to achieve high local drug concentrations. AuNP–MTX conjugates were tested by flow cytometry against lung (A-549) and colon (HTC-116) cancer cell lines. Results for A-549 showed a weaker dose–response e ect than for colon cancer ones. This could be related to the presence of folate receptors in line HTC-116 in comparison to line A-549, supporting the specific uptake of folate-conjugated AuNP–MTX by folate receptor positive tumor cells. Conjugates exhibited considerably higher cytotoxic e ects compared with the e ects of equal doses of free MTX. Annexin V-PI tests sustained the cell death mechanism of apoptosis, which is normally disabled in cancer cells.Spanish GovernmentJunta de Andalucía P18-RT-419