Association of physical fitness components and health-related quality of life in women with systemic lupus erythematosus with mild disease activity

To study the association of different components of physical fitness [flexibility, muscle strength and cardiorespiratory fitness (CRF)] and a clustered fitness score with healthrelated quality of life (HRQoL) in women with systemic lupus erythematosus (SLE) and to analyze whether participants with high fitness level have better HRQoL. This cross-sectional study included 70 women with SLE (aged 42.5; SD 13.9 years). The back-scratch test assessed flexibility, the 30-sec chair stand and handgrip strength tests assessed muscle strength, and the 6-min walk test (n = 49) assessed CRF. HRQoL was assessed through the 36-item Short-Form Health Survey (SF-36). Our study suggests that muscle strength and CRF are positively associated with HRQoL, while flexibility showed contradictory results. These findings highlight the importance of maintaining adequate fitness levels in women with SLE.This work was supported by the Consejería de Salud, Junta de Andalucía (grant number: PI-0525-2016) and the Ilustre Colegio Oficial de Médicos de Granada (Premios de Investigación 2017). BG-C was supported by the Spanish Ministry of Education (FPU15/00002)

The flowchart of the selection of the patients with systemic lupus erythematosus with mild disease activity (<i>n = 47</i>).

<p>The flowchart of the selection of the patients with systemic lupus erythematosus with mild disease activity (<i>n = 47</i>).</p

Linear regression models examining the association of physical activity intensity levels and sedentary time with pulse wave velocity in women with systemic lupus erythematosus <i>(n = 47)</i>.

<p>Linear regression models examining the association of physical activity intensity levels and sedentary time with pulse wave velocity in women with systemic lupus erythematosus <i>(n = 47)</i>.</p

MOESM1 of Identification of candidate genes associated with fibromyalgia susceptibility in southern Spanish women: the al-Ándalus project

Additional file 1: Table S1. TaqMan™ OpenArray™ custom assay designs of candidate gene SNPs included in the present study. Table S2. Rationale for the inclusion of the 64 single nucleotide polymorphisms (SNPs) in the present study. Table S3. Thermal cycling conditions. Table S4. Further details of the single nucleotide polymorphisms (SNP) included in the present study. Table S5. Socio-demographic and clinical characteristics of the study samples. Table S6. Genotype frequencies of single nucleotide polymorphisms (SNP) in fibromyalgia (FM) and non-fibromyalgia (controls, HC) women

Socio-demographic and clinical characteristics in women with systemic lupus erythematosus <i>(n = 47)</i>.

<p>Socio-demographic and clinical characteristics in women with systemic lupus erythematosus <i>(n = 47)</i>.</p

Physical activity intensity levels and sedentary time in women with systemic lupus erythematosus <i>(n = 47)</i>.

<p>Physical activity intensity levels and sedentary time in women with systemic lupus erythematosus <i>(n = 47)</i>.</p

Average PWV (95% confidence interval) in women with SLE meeting and not meeting the PA guidelines.

<p>Average PWV (95% confidence interval) in women with SLE meeting and not meeting the PA guidelines.</p

Cardiovascular risk factors in women with systemic lupus erythematosus <i>(n = 47)</i>.

<p>Cardiovascular risk factors in women with systemic lupus erythematosus <i>(n = 47)</i>.</p