Is High Flow Nasal Oxygenation a Game Changer in Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A pilot study

Objectives: A pilot observational study was done to compare High Flow Nasal Oxygen (HFNO) and supraglottic airway device (SAD) technique in patients undergoing endobronchial ultrasound (EBUS) and transbronchial needle aspiration procedures (TBNA) with an objective to evaluate the efficacy of HFNO  in oncological patients. Methods:  The study was conducted in a tertiary cancer center in Muscat, Sultanate of Oman from May 2022 to March 2023.  Consecutive patients undergoing EBUS TBNA under moderate sedation were quasi-randomized into HFNO and SAD groups. The episodes and duration of hypoxia and the lowest level of oxygen saturation were the primary outcome measured. Results: A total of twenty-four patients were taken into the study of which 10 were in the HFNO group and 14 were in the SAD group with an equal number of males and females.  The duration of the procedure in both the groups was similar (45±20 mins in HFNO vs 44±17 in the SAD group). Mean lowest oxygen saturation in the HFNO group was (93.5%±4), which was statistically significant in comparison to the SAD group (90±6). In both groups, the maximum hypoxia occurred during the early phase of the procedure. However, both the groups were similar for the cumulative duration of hypotension (140 secs in HFNO vs 55 secs in SAD) and bradycardia (25 secs in HFNO vs. 40 secs in SAD). Conclusion: HFNO can be a good alternative to the SAD and could be used safely and efficiently in the cohort of population in patients undergoing EBUS TBNA. Keywords: High flow nasal oxygenation; Endobronchial Ultrasound-guided Transbronchial Needle Aspiration; Supraglottic airway devices

Analysis of wind velocity and release angle effects on discus throw using computational fluid dynamics

The aim of this paper is to study the aerodynamics of discus throw. A comparison of numerical and experimental performance of discus throw with and without rotation was carried out using the analysis of lift and drag coefficients. Initial velocity corresponding to variation angle of around 35.5° was simulated. Boundary condition, on the top and bottom boundary edges of computational domain, was imposed in order to eliminate external influences on the discus; a wind resistance was calculated for the velocity values of 25 and 27 m/s. The results indicate that the flight distance (D) was strongly affected by the drag coefficient, the initial velocity, the release angle and the direction of wind velocity. It was observed that these variables change as a function of discus rotation. In this study, results indicate a good agreement of D between experimental values and numerical results.info:eu-repo/semantics/publishedVersio

Modelling Propelling Force in Swimming Using Numerical Simulations

In the sports field, numerical simulation techniques have been shown to provide useful information about performance and to play an important role as a complementary tool to physical experiments. Indeed, this methodology has produced significant improvements in equipment design and technique prescription in different sports (Kellar et al., 1999; Pallis et al., 2000; Dabnichki & Avital, 2006). In swimming, this methodology has been applied in order to better understand swimming performance. Thus, the numerical techniques have been addressed to study the propulsive forces generated by the propelling segments (Rouboa et al., 2006; Marinho et al., 2009a) and the hydrodynamic drag forces resisting forward motion (Silva et al., 2008; Marinho et al., 2009b). Although the swimmer’s performance is dependent on both drag and propulsive forces, within this chapter the focus is only on the analysis of the propulsive forces. Hence, this chapter covers topics in swimming propelling force analysis from a numerical simulation technique perspective. This perspective means emphasis on the fluid mechanics and computational fluid dynamics methodology applied in swimming investigations. One of the main aims for performance (velocity) enhancement of swimming is to maximize propelling forces whilst not increasing drag forces resisting forward motion, for a given trust. This chapter will concentrate on numerical simulation results, considering the scientific simulation point-of-view, for this practical application in swimming

Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data

The measurement of bisphenol-S (BPS) and its glucurono-conjugate (BPSG) in urine may be used for the biomonitoring of exposure in populations. However, this requires a thorough knowledge of their toxicokinetics. The time courses of BPS and BPSG were assessed in accessible biological matrices of orally and dermally exposed volunteers. Under the approval of the Research Ethics Committee of the University of Montreal, six volunteers were orally exposed to a BPS-d8 deuterated dose of 0.1 mg/kg body weight (bw). One month later, 1 mg/kg bw of BPS-d8 were applied on 40 cm2 of the forearm and then washed 6 h after application. Blood samples were taken prior to dosing and at fixed time periods over 48 h after treatment; complete urine voids were collected pre-exposure and at pre-established intervals over 72 h postdosing. Following oral exposure, the plasma concentration–time courses of BPS-d8 and BPSG-d8 over 48 h evolved in parallel, and showed a rapid appearance and elimination. Average peak values (±SD) were reached at 0.7 ± 0.1 and 1.1 ± 0.4 h postdosing and mean (±SD) apparent elimination half-lives (t½) of 7.9 ± 1.1 and 9.3 ± 7.0 h were calculated from the terminal phase of BPS-d8 and BPSG-d8 in plasma, respectively. The fraction of BPS-d8 reaching the systemic circulation unchanged (i.e. bioavailability) was further estimated at 62 ± 5% on average (±SD) and the systemic plasma clearance at 0.57 ± 0.07 L/kg bw/h. Plasma concentration–time courses and urinary excretion rate profiles roughly evolved in parallel for both substances, as expected. The average percent (±SD) of the administered dose recovered in urine as BPS-d8 and BPSG-d8 over the 0–72 h period postdosing was 1.72 ± 1.3 and 54 ± 10%. Following dermal application, plasma levels were under the lower limit of quantification (LLOQ) at most time points. However, peak values were reached between 5 and 8 h depending on individuals, suggesting a slower absorption rate compared to oral exposure. Similarly, limited amounts of BPS-d8 and its conjugate were recovered in urine and peak excretion rates were reached between 5 and 11 h postdosing. The average percent (±SD) of the administered dose recovered in urine as BPS-d8 and BPSG-d8 was about 0.004 ± 0.003 and 0.09 ± 0.07%, respectively. This study provided greater precision on the kinetics of this contaminant in humans and, in particular, evidenced major differences between BPA and BPS kinetics with much higher systemic levels of active BPS than BPA, an observation explained by a higher oral bioavailability of BPS than BPA. These data should also be useful in developing a toxicokinetic model for a better interpretation of biomonitoring data

The gliding phase in swimming: the effect of water depth

Aiming to achieve higher performances, swimmers should maximize each component of swimming races. During starts and turns, the gliding phase represents a determinant part of these race components. Thus, the depth position allowing minimizing the hydrodynamic drag force represents an important concern in swimming research. The aim of this study was to analyse the effect of depth on drag during the underwater gliding, using computational fluid dynamic

Parametric investigations of short length hydro-dynamically lubricated conical journal bearing

Due to the growing need for compact size fluid film bearings, efforts are being made to explore the performance of hydro-dynamically lubricated short length conical journal bearing. The combined radial and axial load carrying features of these bearings emerge as a better option to replace the two separate bearings (journal and thrust pad bearings) employed in turbo-machines and other applications. Thus, in this study, attempts have been made to investigate the performance of conical hydrodynamic journal bearing by using finite element analysis. The bearings have been investigated for semi-cone angle (γ = 10°), aspect ratio (λ = 0.5, 0.8, 1.0), journal speed (v = 2.6, 5.2 m/s) and load variations in terms of eccentricity ratio (ε) up to 0.6. Results have been presented in terms of radial and axial load carrying capacity, stiffness coefficients, damping coefficients and threshold speed. Results from the present study reveal that load carrying capacity is improved with higher aspect ratio; whereas threshold speed decreases with the increase of eccentricity ratio and aspect ratio

Long-Term Genomic and Epigenomic Dysregulation as a Consequence of Prenatal Alcohol Exposure: A Model for Fetal Alcohol Spectrum Disorders

There is abundant evidence that prenatal alcohol exposure leads to a range of behavioral and cognitive impairments, categorized under the term fetal alcohol spectrum disorders (FASDs). These disorders are pervasive in Western cultures and represent the most common preventable source of neurodevelopmental disabilities. The genetic and epigenetic etiology of these phenotypes, including those factors that may maintain these phenotypes throughout the lifetime of an affected individual, has become a recent topic of investigation. This review integrates recent data that has progressed our understanding FASD as a continuum of molecular events, beginning with cellular stress response and ending with a long-term footprint of epigenetic dysregulation across the genome. It reports on data from multiple ethanol-treatment paradigms in mouse models that identify changes in gene expression that occur with respect to neurodevelopmental timing of exposure and ethanol dose. These studies have identified patterns of genomic alteration that are dependent on the biological processes occurring at the time of ethanol exposure. This review also adds to evidence that epigenetic processes such as DNA methylation, histone modifications, and non-coding RNA regulation may underlie long-term changes to gene expression patterns. These may be initiated by ethanol-induced alterations to DNA and histone methylation, particularly in imprinted regions of the genome, affecting transcription which is further fine-tuned by altered microRNA expression. These processes are likely complex, genome-wide, and interrelated. The proposed model suggests a potential for intervention, given that epigenetic changes are malleable and may be altered by postnatal environment. This review accentuates the value of mouse models in deciphering the molecular etiology of FASD, including those processes that may provide a target for the ammelioration of this common yet entirely preventable disorder

THE EFFECT OF WEARING A CAP ON THE SWIMMER PASSIVE DRAG

The purpose of this study was to analyse the effect of wearing a cap on swimmer passive drag. A computational fluid dynamics analysis was carried-out to determine the hydrodynamic drag of a female swimmer’s model: (i) wearing a swimming cap and; (ii) with no cap. The three-dimensional surface geometry of a female swimmer’s model with cap and with no cap was acquired through standard commercial laser scanner. Passive drag force and drag coefficient were computed with the swimmer in a streamlined position. Higher hydrodynamic drag values were determined when the swimmer was with no cap in comparison with the situation when the swimmer was wearing a cap. In conclusion, one can state that wearing a swim cap may positively influence swimmer’s hydrodynamics

Computational fluid dynamics: the analysis of drag coefficient during the gliding phase

The aim of the current study was to analyse the effect of depth on hydrodynamic drag coefficient during the underwater gliding, using computational fluid dynamics.This work was supported by FCT (PTDC/DES/098532/2008