Protective effect of ginseng against gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats

This study investigated the potential protective effects of ginseng on gamma-irradiation-induced oxidative stress and endothelial dysfunction in rats. Twenty four male albino rats were divided into four groups. In the control group, rats were administered vehicle by tube for 7 consecutive days. The second group was administered ginseng extract (100 mg/kg, by gavage) for 7 consecutive days. Animals in the third group were administered vehicle by tube for 7 consecutive days, then exposed to single dose gamma-irradiation (6 Gy). The Fourth group received ginseng extract for 7 consecutive days, one hour later rats were exposed to gamma-irradiation. Oral administration of ginseng extract prior to irradiation produced a significant protection which was evidenced by a significant reduction in serum creatine kinase (CPK) and lactate dehydrogenase (LDH) activities and asymmetric dimethylarginine (ADMA), urea and creatinine levels with significant increase in serum total nitrate/nitrite (NO(x)) level. Moreover, ginseng significantly increased cardiac and renal superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities, and reduced glutathione (GSH) content, associated with a significant depletion in malondialdehyde (MDA) and NO(x) levels compared to irradiated group. This study suggests that ginseng may serve as a potential protective agent against gamma-irradiation-induced cardio-nephrotoxicity via enhancing the antioxidant activity and inhibition of endothelial dysfunction

The impact of the western liberal arts education in the MENA region: A case study

This study focuses on the development of the millennial generation within the liberal arts education setting. It has been demonstrated that the values of different generations periodically change. It is the university\u27s duty to articulate the distinctive sociological, ideological, and psychological variations of each generation in order to provide the most viable educational system. Follow-up researches in different educational systems should be conducted regularly in order to incorporate new data from the rapidly changing millennial generation. This particular research focuses on understanding student development models that adequately demonstrate the effectiveness of a liberal arts education within the MENA region. The emphasis of this paper is on Arab students within transnational settings, focusing on the American University in Cairo and the American University of Kuwait

The impact of national culture on the adoption of e-tourism in Egyptian tourism companies

Many previous studies shed light on the importance of studying the factors that preclude effective adoption of technology in the tourism industry. Prior studies also affirmed the presence of a relationship between the national culture, the acceptance of technology, and the effective adoption thereof. However, those studies differ in the cultural variables used and in results on their influence on technology adoption. This study used the national culture theory of Hofstede (2010) and the Technology Acceptance Model (Davis, 1989) to measure the impact of national culture and normative beliefs of marketing managers on the adoption of e-tourism. Data analysis was carried out using multiple linear regressions and one-way analysis of variance (ANOVA). The results showed that the culture of uncertainty avoidance had a significant positive impact on perceived ease of use and perceived usefulness. Each of the last two elements also affected the attitudes of marketing managers in tourism companies towards e-tourism and their intention to use it. Also, the results affirmed that long-term orientation culture has no significant impact on the perceived usefulness, ease of use or actual use of e-tourism for Egyptian tourism companies. It however seems to affect quality or/and effective adoption of e-tourism business

Formulation and In-vitro Characterization of Metformin Hydrochloride-loaded Liposomes

The aim of study. is to formulate Metformin hydrochloride-loaded novel liposomal vesicles and investigate their physical stability. A new metformin hydrochloride (Met-HCL) liposomal formulation was prepared  for topical delivery. Traditionally, the biguanide metformin could be categorized the first line in treatment of diabetes. The prepared metformin hydrochloride-loaded liposomal vesicles were investigated  for different in vitro characterisations. Eleven different formulations were developed adopting a thin film hydration method using different molar concentrations of Phospholipon® 90G, cholesterol and metformin hydrochloride. The effect of varying concentrations of Phospholipon® 90G, cholesterol and metformin hydrochloride on entrapment efficiency percent, ex-vivo skin permeation percentage, vesicle size and zeta potential was studied. Metformin-loaded liposome stability over a period of time 90 days was investigated. Results. The optimized metformin hydrochloride liposomes, F2, F6 and F11 were selecte. The selected formulations displayed highly efficient permeation percent via the excised mice skin 53±0.09 %, 30±0.4 % and 40±0.02 % respectively. The formulations showed EE % of  80±0.09 %, 28.6±0.02 % and 71.8±0.4 % respectively. Morphology of F2  liposomal surface revealed spherical three-dimensional structure. The stability study revealed about 10-23 percent drug leaching out of the vesicular liposomes (F2) within 90 days. Conclusion. Metformin hydrochloride-loaded liposomal vesicles can provide a potentially promising and convenient approach for topical delivery

THE USE OF PHYSICAL PHENOMENON AS AN INNOVATIVE SOURCE IN ART EDUCATION

It is undoubtable that there is a reciprocity relationship between the different sciences and fields of knowledge. The relation between art and science is one that extends ancient times since both of them use search and experimentation methods in pursuit of reaching the best results and satisfactory solutions which makes them in continuous development. Likewise, Art education draws its references and aesthetic values from all that is found neoteric whether it is in nature, heritage or other sciences. The idea of integration between art and science prompts on finding innovative ways towards creativity, because whenever the sources behind the design were of a scientific nature, the higher the visual connotations are closer to perception and mental receptivity. Hence, researchers are trying to create new experimental approaches through the study and analysis of some physical phenomena, such as energy, frequency and vibration, which produces precise and perfect artistic forms in harmonious rhythms and in accordance with formalized geometric and mathematical relations of scientific origin that can be used by art students to create innovative design works as intellectual starting points, can be consulted and relied on as technical references, with a formal logic, and mental legitimation, which contributes to the enrichment of the aesthetic values ​​of the art work. So, this study aims to take advantage of some physical phenomena such as energy and frequency and vibration and its formal output as an innovative source in teaching arts

Geothermal studies in oilfield districts of Eastern Margin of the Gulf of Suez, Egypt

AbstractResults of geothermal studies carried out at 149 onshore oil wells have been used in evaluation of temperature gradient and heat flow values of the eastern shore of the Gulf of Suez. The investigations included temperature logs in boreholes, calculation of amplitude temperature, geothermal gradients and heat flow. The results obtained indicate that geothermal gradient values are in the ranges of 0.02–0.044°C/m and regionally averaged mean heat flow values are found to fall in the interval of 45–120mW/m2. Temperature gradients and heat flow values change from low values eastward to high values toward the axial of Gulf of Suez rift. The result of this research work has been highly successful in identifying new geothermal resources eastward of the Gulf of Suez. Additionally, this study shows that the areas with relatively higher temperature gradients have lower oil window, mature earlier, than those with low gradient values. Thus, high temperature gradients cause to expedite the formation of oil at relatively shallow depths and narrow oil windows. On the other hand, low temperature gradient makes the oil window to be quite broad when locate at high depths

Metabolic Syndrome and Cardiovascular Risk Factors in Obese Adolescent

BACKGROUND: Childhood and adolescent obesity is associated with insulin resistance, abnormal glucose metabolism, hypertension, dyslipidemia, inflammation, liver disease, and compromised vascular function. The purpose of this study was to determine the prevalence of cardiovascular risk factor abnormalities and metabolic syndrome in a sample of obese adolescent as prevalence data might be helpful in improving engagement with obesity treatment in future. The high blood lipid levels and obesity are the main risk factors for cardio vascular diseases. Atherosclerotic process begins in childhood.AIM: This study aimed to investigate the relationship between obesity in adolescent and their blood lipids levels and blood glucose level.METHODS: This study was conducted with 100 adolescents of both gender age 12-17 years and body mass index (BMI) greater than 95th percentiles and 100 normal adolescents as control group. The blood samples were collected from all adolescents after overnight fasting (10 hours) to analyze blood lipids (Total cholesterol, high density lipoprotein, low density lipoprotein) and hematological profile (Hemoglobin, platelets and red blood cell, C reactive protein and fasting blood glucose.RESULTS: There were statistical difference between the two groups for red blood cells (P<0.001), Hemoglobin (P < 0.001) and platelets (P = 0.002), CRP (P = 0.02). Positive correlation was found between the two groups as regards total cholesterol (P = 0.0001), P value was positive for HDL (P = 0.005 and Atherogenic index P value was positive (P = 0.002). Positive correlation was found between the two group as regards fasting blood glucose (P = 0.001).CONCLUSION:  Saturated fat was associated with elevated lipid levels in obese children. These results reinforce the importance of healthy dietary habits since child-hood in order to reduce the risks of cardiovascular diseases in adulthood

The Rule of “Reward of the Kind of Work and Its Applications in the Propaganda in the Stories of the Qur’an and the Sunnah of the Prophet

The study dealt with the subject of advocacy, which is the rule of reward for work and the applications of advocacy in the Qur’anic stories and a look at the Prophet’s biography. The study was based on the inductive, analytical and deduction approach by extrapolating the most important books of fundamentalists and interpreters and the most important rule to stand on the basis of a rule and a rule that indicates it from rulings, and the science of legal texts to reach the legal collection of the rule, and to clarify the scientific applications of the Qur’anic rule and the Prophet’s biography in the field of advocacy. The study reached the field of advocacy for the advocacy applications of the penalty rule of the sex of work, and we have come across many points of advocacy applications in the Qur’anic stories, including God’s reward for our master Ibrahim, peace be upon him, after his people plotted against him and they wanted to burn him, so God made the fire and peace be upon him and made him a role model and nation to the worlds And it has been shown that the Prophet’s biography is also full of advocacy applications for the great public, including God’s reward for the hypocrites who stayed behind from the Tabuk expedition for fear of the heat by promising them more caution