IN VITRO AND IN SILICO BIOLOGICAL ACTIVITY OF NEW IBUPROFEN HYBRIDS

Herein we report the biological evaluation of new hybrids of 1,2,3,4-tetrahydroisoquinoline with ibuprofen. The hybrids are screened for their in vitro inhibition of albumin denaturation, antioxidant, and antitryptic activity. The tested compounds have shown significant results. The lipophilicity was established using both reversed-phase thin layer chromatography and in silico calculations

SYNTHESIS OF 1,4-DISUBSTITUTED ISOQUINOLINES AS CHERYLLINE DERIVATIVES

Synthetic studies of aryl-l,2,3,4-tetrahydroisoquinolines have attracted much attention from the synthetic community owing to the potential biological activities of this class of compounds and their increasing medicinal interest. The alkaloid cherylline is a naturally occurring optically active, 4-aryl-1,2,3,4- tetrahydroisoquinoline alkaloid, isolated from Crinum Powellii, Amaryllidaceae plant. There are many ways for cherylline synthesis. An application of Bischler-Napieralski reaction for the synthesis of new 1,4-disubstituted- 1,2,3,4- tetrahydroisoquinolines as cherylline derivatives, is described

A brief review of Cherylline synthesis

1301-13201,2,3,4-Tetrahydroisoquinolines are an important class of synthetic and natural compounds, which display a broad range of medicinal activities. The 1,2,3,4-tetrahydroisoquinoline system has attracted attention not only because of its biological activities, but also due to its presence as a basic framework in many naturally occurring products and drugs. Their skeletons are unique among the Amaryllidaceae alkaloids and they have long been alluring targets for synthetic chemists as witnessed by a number of articles dealing with biogenesis, isolation, characterization and synthesis. The alkaloid cherylline is an optically active naturally occurring, 4-phenyl-1,2,3,4-tetrahydroisoquinoline alkaloid, isolated from Crinum powelli, Amaryllidaceae plant. There are many ways for cherylline synthesis. In this short review is described the different methods for synthesis of the alkaloid cherylline

GREEN SYNTHESIS OF NEW HYBRID MOLECULES OF IBUPROFEN AND 1,2,3,4-TETRAHYDROISOQUINOLINE

Herein we report an eco-friendly method for synthesis of 1,2,3,4-tetrahydroisoquinoline derivatives of ibuprofen. All five newly obtained compounds are fully characterized with their 1H,13C-NMR, IR, HRMS, and are interesting for the purpose of studying their biological activities

SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES

Ketoprofen is a widespread non-steroidal anti-inflammatory agent used in treatment of acute pain and chronic arthritis. On the other hand, isoquinoline alkaloids are very well known with their wide range of biological activities. From this point of view it is of interest to us to obtain new isoquinolines containing a ketoprofen residue in their structure as new substances with potential biological activity. To estimate general efficacy and safety of the newly obtained compounds, their biological potential has been evaluated

INVESTIGATION OF ANTIOXIDANT ACTIVITY OF DIFFERENT EXTRACTS OF HELICHRYSUM ITALICUM FROM BULGARIA

Helichrysum italicum from the daisy family Asteraceae have been used in the folk medicine for many years for preventive purposes and for restoring the body after a heart attack. The plant material from H. italicum was provided by the Institute of Roses and Essential Oils, Kazanlak, Bulgaria. The antioxidant activity of different H. italicum extracts was evaluated by various methods, such as ABTS, CUPRAC, FRAP and DPPH

ANTIOXIDANT ACTIVITY IN TWO SPECIES COMMON BEANS (PHASEOLUS VULGARIS L.) FROM VILLAGE OF SMILYAN, BULGARIA

Smilyan beans are called bean seeds, one of the few Bulgarian foods protected by a trademark patent for its cultivation in the area of the upper valley of Arda River. Smilyan beans have a unique taste and are famous both in Bulgaria and abroad. Common beans (Phaseolus vulgaris L.) from two different cultivars from village of Smilyan were sieve analyzed and assessed for antioxidant activities