Tradução comentada: fatores de risco três meses após a UCI

Mestrado em Tradução EspecializadaO trabalho consiste na tradução e no relatório da tradução de um artigo científico da área da medicina, relativo aos efeitos secundários ocorridos três meses depois do tratamento na Unidade de Cuidados Intensivos. Pretende-se identificar e comentar os principais problemas de tradução. A criação de um glossário com a terminologia específica encontrada no texto de partida foi de suma importância para ultrapassar e resolver os problemas terminológicos.The work consists in the translation and translation report of a scientific research on the secondary effects that occurred three months after the treatment in the Intensive Care Unit. The objective is to identify and overcome the main translation problems. The creation of a glossary containing the specific terminology found in the source text was of great importance, helping to overcome and solve the terminology problems

Orbitofrontal-Striatal Structural Alterations Linked to Negative Symptoms at Different Stages of the Schizophrenia Spectrum

Negative symptoms such as anhedonia and apathy are among the most debilitating manifestations of schizophrenia (SZ). Imaging studies have linked these symptoms to morphometric abnormalities in 2 brain regions implicated in reward and motivation: the orbitofrontal cortex (OFC) and striatum. Higher negative symptoms are generally associated with reduced OFC thickness, while higher apathy specifically maps to reduced striatal volume. However, it remains unclear whether these tissue losses are a consequence of chronic illness and its treatment or an underlying phenotypic trait. Here, we use multicentre magnetic resonance imaging data to investigate orbitofrontal-striatal abnormalities across the SZ spectrum from healthy populations with high schizotypy to unmedicated and medicated first-episode psychosis (FEP), and patients with chronic SZ. Putamen, caudate, accumbens volume, and OFC thickness were estimated from T1-weighted images acquired in all 3 diagnostic groups and controls from 4 sites (n = 337). Results were first established in 1 discovery dataset and replicated in 3 independent samples. There was a negative correlation between apathy and putamen/accumbens volume only in healthy individuals with schizotypy; however, medicated patients exhibited larger putamen volume, which appears to be a consequence of antipsychotic medications. The negative association between reduced OFC thickness and total negative symptoms also appeared to vary along the SZ spectrum, being significant only in FEP patients. In schizotypy, there was increased OFC thickness relative to controls. Our findings suggest that negative symptoms are associated with a temporal continuum of orbitofrontal-striatal abnormalities that may predate the occurrence of SZ. Thicker OFC in schizotypy may represent either compensatory or pathological mechanisms prior to the disease onset