Efeito de apoptose do inositol hexafosfato no marcador biológico Itpr3 em carcinogênese induzida de colo em ratos

Purpose: To study the effect of the modulation of inositol hexaphosphate (IP6) in the biological immunohistochemistry expression of cellular signaling marker apoptosis, in model of carcinogenesis of colon induced by azoxymethane (AOM). Methods: Wistar rats (N= 112) distributed in 4 groups (n=28): Control; B, AOM (5 mg kg(-1), 2x, to break week 3); C, IP6 (in water 1 %, six weeks); D, IP6+AOM. Weekly euthanasia (n=7), from week three. Immunohistochemistry of ascendant colon with biological marker inositol 1,4,5 triphosphate receptor type III (Itpr3). Quantification of the immune-expression with use of computer-assisted image processing. Analysis statistics of the means between groups, weeks in groups, groups in weeks, and established significance when p <= 0.05. Results: One proved significant difference between groups in the expression of Itpr3, p < 0.0001;with Itpr3 reduction of BxD group, p < 0.001. Conclusion: Inositol hexaphosphate promotes modulation of biological markers with reduction of Itpr3 in carcinogenesis of colon.Federal University of Mato Grosso of SouthUniv Fed Sao Paulo, Dept Surg, Postgraduat Program Surg & Experimentat, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Surg, Div Operat Techn & Expt Surg, Sao Paulo, BrazilUFMS MS, Dept Surg, Sao Luis, Maranhao, BrazilUFMS MS, Dept Food Technol & Publ Hlth, Sao Luis, Maranhao, BrazilUniv Fed Sao Paulo, Dept Surg, Postgraduat Program Surg & Experimentat, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Surg, Div Operat Techn & Expt Surg, Sao Paulo, BrazilWeb of Scienc