How can micro and small enterprises in Sub-Saharan Africa become more productive? the impacts of experimental basic managerial training

The vast majority of micro and small enterprises in developing countries are located in industrial clusters, and the majority of such clusters have yet to see their growth take off. The performance of micro and small enterprise clusters is especially low in Sub-Saharan Africa. While existing studies often attribute the poor performance to factors outside firms, problems within firms are seldom scrutinized. Entrepreneurs in these clusters are unfamiliar with standard business practices. Based on a randomized experiment in Ghana, this study demonstrates that basic-level management training improves business practices and performance, although the extent of improvement varies considerably among entrepreneurs.Labor Policies,Primary Education,Access&Equity in Basic Education,Education For All,E-Business

How Can Micro and Small Enterprises in Sub-Saharan Africa Become More Productive? The Impacts of Experimental Basic Managerial Training

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Teaching KAIZEN to small business owners: An experiment in a metalworking cluster in Nairobi

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教師の言葉と権力 : 教員養成大学の学生を対象とした“ニセ科学”を題材とした授業の分析から

The purpose of this study was to investigate the influence of teachers\u27 words on “fake science\u27\u27 in schools based on the results of a questionnaire survey and classes. According to my survey of junior high school students in the Kyushu region, 70% believe in “fake science.” And when the university faculty used “fake science” for teaching students who wanted to be teachers, most of the students in the class believed in “fake science.\u27\u27 Teachers\u27 words are so powerful that even college students believe in “fake science.\u27\u27 The teacher who shoulders the responsibility for public education must be conscious of the power of the language which he emits, because the speech and guidance are the exercise of the public authority

PlexinD1 signaling controls domain-specific dendritic development in newborn neurons in the postnatal olfactory bulb

Newborn neurons show immature bipolar morphology and continue to migrate toward their destinations. After the termination of migration, newborn neurons undergo spatially controlled dendrite formation and change into a complex morphology. The mechanisms of dendritic development of newborn neurons have not been fully understood. Here, we show that in the postnatal olfactory bulb (OB), the Sema3E-PlexinD1 signaling, which maintains bipolar morphology of newborn neurons, also regulates their dendritic development after the termination of migration in a dendritic domain-specific manner. Genetic ablation of Sema3E or PlexinD1 enhanced dendritic branching in the proximal domain of the apical dendrites of OB newborn granule cells, whereas PlexinD1 overexpression suppressed it in a Rho binding domain (RBD)-dependent manner. Furthermore, RhoJ, a small GTPase that directly binds to PlexinD1RBD in vascular endothelial cells, is expressed in migrating and differentiating newborn granule cells in the OB and is also involved in the suppression of proximal branching of their apical dendrites. These results suggest that the Sema3E-PlexinD1-RhoJ axis regulates domain-specific dendrite formation of newborn neurons in the postnatal OB

Governance of fertilizer quality in Vietnam: government and market initiatives

Governance of fertilizer quality is an important topic of food policy because prevalence of low-quality fertilizers hinders the farmers’ use of fertilizers and stagnate agricultural productivity growth. This paper investigates the prevalence of low-quality fertilizers and describes the initiatives and measures that have been taken against the problem. We tested 141 randomly sampled fertilizers in the Mekong Delta region to examine the quality of fertilizers in the market and find that the average deviation rate from the nutrient levels indicated on the label is small. However, the quality varies substantially, and half of the samples have at least one nutrient less than the legal threshold. We conduct in-depth field observations and interviews with stakeholders and identify three initiatives to control fertilizer quality in the markets: 1) government regulation and control through licensing, mandatory quality labeling, and random inspections; 2) producer’s effort in maintaining quality and brand through warranty and dealer certifications; and 3) retailers’ updating of product assortments based on farmers’ feedback. We highlight the importance of public regulations by discussing how government and market initiatives interact and complement each other

Teaching KAIZEN to Small Business Owners: An Experiment in a Metalworking Cluster in Nairobi

経済学 / EconomicsIn recent years, managerial capital has received attention as one of the major determinants of enterprise productivity, growth, and longevity. This paper attempts to assess the impacts of a management training program on the business performance of small enterprises in a metalworking cluster in Nairobi, Kenya. A previous study of this cluster observed that while several enterprises had successfully expanded operation, the majority had been experiencing declining profits due to increasing competition with imported products and with new entrants in the cluster. Based on the observed differences in management between successful and less successful enterprises, we designed a management training program featuring the basics of KAIZEN, an inexpensive, commonsense approach to management emphasizing the reduction of wasted work and materials, for the less successful enterprises. Although our initial intention was to use this training program as a randomized experiment, we had to abandon randomization and allow every business owner interested in the program to participate in it, due to circumstances beyond our control. This paper finds that business owners operating smaller enterprises tended to be self-selected into training participation. The training effects combined with the self-selection effect, which we estimate with panel data, were statistically significant and particularly stronger on profits than on sales revenues, while other training programs that did not teach KAIZEN had positive effects on sales revenues, not profits. As a result, the participants caught up with and overtook the non-participants in terms of average sales revenues and average profits, respectively.http://www.grips.ac.jp/list/jp/facultyinfo/sonobe_tetsushi

TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment

Background Patients with cancer benefit from treatment with immune checkpoint inhibitors (ICIs), and those with an inflamed tumor microenvironment (TME) and/or high tumor mutation burden (TMB), particularly, tend to respond to ICIs; however, some patients fail, whereas others acquire resistance after initial response despite the inflamed TME and/or high TMB. We assessed the detailed biological mechanisms of resistance to ICIs such as programmed death 1 and/or cytotoxic T-lymphocyte-associated protein 4 blockade therapies using clinical samples. Methods We established four pairs of autologous tumor cell lines and tumor-infiltrating lymphocytes (TILs) from patients with melanoma treated with ICIs. These tumor cell lines and TILs were subjected to comprehensive analyses and in vitro functional assays. We assessed tumor volume and TILs in vivo mouse models to validate identified mechanism. Furthermore, we analyzed additional clinical samples from another large melanoma cohort. Results Two patients were super-responders, and the others acquired resistance: the first patient had a non-inflamed TME and acquired resistance due to the loss of the beta-2 microglobulin gene, and the other acquired resistance despite having inflamed TME and extremely high TMB which are reportedly predictive biomarkers. Tumor cell line and paired TIL analyses showed high CD155, TIGIT ligand, and TIGIT expression in the tumor cell line and tumor-infiltrating T cells, respectively. TIGIT blockade or CD155-deletion activated T cells in a functional assay using an autologous cell line and paired TILs from this patient. CD155 expression increased in surviving tumor cells after coculturing with TILs from a responder, which suppressed TIGIT+ T-cell activation. Consistently, TIGIT blockade or CD155-deletion could aid in overcoming resistance to ICIs in vivo mouse models. In clinical samples, CD155 was related to resistance to ICIs in patients with melanoma with an inflamed TME, including both primary and acquired resistance. Conclusions The TIGIT/CD155 axis mediates resistance to ICIs in patients with melanoma with an inflamed TME, promoting the development of TIGIT blockade therapies in such patients with cancer

How Can Micro and Small Enterprises in Sub-Saharan Africa Become More Productive? The Impacts of Experimental basic Managerial Training

経済学 / EconomicsThe vast majority of micro and small enterprises (MSEs) in developing countries are located in industrial clusters, and the majority of such clusters have yet to see their growth take off. The performance of MSE clusters is especially low in Sub-Saharan Africa. While existing studies often attribute the poor performance to factors outside firms, problems within firms are seldom scrutinized. In fact, entrepreneurs in these clusters are unfamiliar with standard business practices. Based on a randomized experiment in Ghana, this study demonstrates that basic-level management training improves business practices and performance.JEL Classification Codes: M31, M41, O14, C93http://www.grips.ac.jp/list/jp/facultyinfo/sonobe_tetsushi