139 research outputs found
Clinical microbiological case: a 35-year-old HIV-positive man with intermittent fever and chronic diarrhea
ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΌΠΈΠ³ΡΠ°ΡΠΈΠΈ Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π° Π² ΡΠΈΡΠ°Π½Π΅ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ
Π ΡΠ°Π±ΠΎΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ ΠΏΡΠΎΡΠ΅ΡΡ Π΄ΠΈΡΡΡΠ·ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ° Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π° Π² ΡΠΈΡΠ°Π½ΠΎΠ²ΠΎΠΉ ΠΏΠ»Π°ΡΡΠΈΠ½Π΅ Π²ΠΈΡ
ΡΠ΅ΡΠΎΠΊΠΎΠ²ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎ Π³Π»ΡΠ±ΠΈΠ½Π΅ ΠΎΠ±ΡΠ°Π·ΡΠ°. ΠΠ½ΡΠ΅Π³ΡΠ°Π»ΡΠ½ΡΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΎΡ ΠΈΠ·ΡΡΠ΅Π½ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ΅ΡΠΌΠΎΡΠ΄Ρ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ° Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΌΠΈΠ³ΡΠ°ΡΠΈΠΈ Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π° Π² ΡΠΏΠ»Π°Π²Π΅ ΡΠΈΡΠ°Π½Π° ΠΏΡΠΈ Π΅Π³ΠΎ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈ Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΡΠΈΠΎΠΊΠ°ΡΠ±ΠΎΠΌΠΈΠ΄Π°. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΡΠΎΠ»Ρ ΡΠΈΠΎΠΊΠ°ΡΠ±Π°ΠΌΠΈΠ΄Π°. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ Π²ΠΈΡ
ΡΠ΅Π²ΡΡ
ΡΠΎΠΊΠΎΠ² ΠΏΠΎ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½Π°ΡΠ΅ ΠΈ Π²ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ°ΡΡΠΎΡΠ°Ρ
, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΡ ΠΌΠΈΠ³ΡΠ°ΡΠΈΠΈ Π½Π° ΡΠ°Π·Π½ΡΡ
Π³Π»ΡΠ±ΠΈΠ½Π°Ρ
ΠΎΠ±ΡΠ°Π·ΡΠ°. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ ΠΏΡΠΎΡΠ΅ΡΡ ΠΌΠΈΠ³ΡΠ°ΡΠΈΠΈ Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π° Π² ΡΠΈΡΠ°Π½ΠΎΠ²ΠΎΠΌ ΡΠΏΠ»Π°Π²Π΅ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ΅ΡΠΌΠΎΡΠ΄Ρ.The process of diffusion transport of hydrogen in a titanium plate by the eddy current method has been investigated in the depth of samples. The integral transport has been studied by measuring thermoelectric powers. An installation was developed for studying the process of hydrogen shift in titanium alloys when electrolytically saturated with thiocarbomide. The role of thiourea is investigated. The measurement of eddy currents in coordinate and time is carried out at different frequencies, which makes it is possible to study the shift processes at different depths of the sample. The process of hydrogen shift in titanium alloys is studied by measuring thermoelectric powers
Telaprevir for Previously Treated Chronic HCV Infection
Cellular mechanisms in basic and clinical gastroenterology and hepatolog
Chronic Hepatitis C treatment for genotype 2 or 3 in Brazil: cost effectiveness analysis of peginterferon plus ribavirin as first choice treatment
Sustained virological response to treatment of chronic hepatitis C with peginterferon alfa and ribavirin
Risk factors and outcomes associated with recurrent autoimmune hepatitis following liver transplantation
Background & Aims: Autoimmune hepatitis can recur after liver transplantation (LT), though the impact of recurrence on patient and graft survival has not been well characterized. We evaluated a large, international, multicenter cohort to identify the probability and risk factors associated with recurrent AIH and the association between recurrent disease and patient and graft survival.Methods: We included 736 patients (77% female, mean age 42 +/- 1 years) with AIH who underwent LT from January 1987 through June 2020, among 33 centers in North America, South America, Europe and Asia. Clinical data before and after LT, biochemical data within the first 12 months after LT, and immunosuppression after LT were analyzed to identify patients at higher risk of AIH recurrence based on histological diagnosis.Results: AIH recurred in 20% of patients after 5 years and 31% after 10 years. Age at LT <= 42 years (hazard ratio [HR] 3.15; 95% CI 1.22-8.16; p = 0.02), use of mycophenolate mofetil post-LT (HR 3.06; 95% CI 1.39-6.73; p = 0.005), donor and recipient sex mismatch (HR 2.57; 95% CI 1.39-4.76; p = 0.003) and high IgG pre-LT (HR 1.04; 95% CI 1.01-1.06; p = 0.004) were associated with higher risk of AIH recurrence after adjusting for other confounders. In multivariate Cox regression, recurrent AIH (as a time-dependent covariate) was significantly associated with graft loss (HR 10.79, 95% CI 5.37-21.66, p <0.001) and death (HR 2.53, 95% CI 1.48-4.33, p = 0.001).Conclusion: Recurrence of AIH following transplant is frequent and is associated with younger age at LT, use of mycophenolate mofetil post-LT, sex mismatch and high IgG pre-LT. We demonstrate an association between disease recurrence and impaired graft and overall survival in patients with AIH, highlighting the importance of ongoing efforts to better characterize, prevent and treat recurrent AIH.Lay summary: Recurrent autoimmune hepatitis following liver transplant is frequent and is associated with some recipient features and the type of immunosuppressive medications use. Recurrent autoimmune hepatitis negatively affects outcomes after liver transplantation. Thus, improved measures are required to prevent and treat this condition. (C) 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.Cellular mechanisms in basic and clinical gastroenterology and hepatolog
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