4 research outputs found
Re: "Neonatal Bilirubin Levels and Childhood Asthma in the US Collaborative Perinatal Project, 1959-1965"
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Controlled Direct Effects of Preeclampsia on Neonatal Health After Accounting for Mediation by Preterm Birth
- Author
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Genome-wide physical activity interactions in adiposity:a meta-analysis of 200,452 adults
- Author
- Aadahl M. (Mette)
- Abecasis G. R. (Goncalo R.)
- Adair L. S. (Linda S.)
- Ahluwalia T. S. (Tarunveer S.)
- Ahmad S. (Shafqat)
- Amin N. (Najaf)
- Auvinen J. (Juha)
- Balkau B. (Beverley)
- Bandinelli S. (Stefania)
- Barata L. (Llilda)
- Barroso I. (Ines)
- Beilby J. (John)
- Bellis C. (Claire)
- Bergman R. N. (Richard N.)
- Bergmann S. (Sven)
- Bertoni A. G. (Alain G.)
- Bielak L. F. (Lawrence F.)
- Bien S. (Stephanie)
- Blangero J. (John)
- Boehnke M. (Michael)
- Boerwinkle E. (Eric)
- Bonnefond A. (Amelle)
- Bonnycastle L. L. (Lori L.)
- Boomsma D. I. (Dorret I.)
- Borecki I. B. (Ingrid B.)
- Borja J. B. (Judith B.)
- Bouchard C. (Claude)
- Brage S. (Soren)
- Bragg-Gresham J. L. (Jennifer L.)
- Busonero F. (Fabio)
- Buyske S. (Steve)
- Cadby G. (Gemma)
- Campbell H. (Harry)
- Chambers J. C. (John C.)
- Chasman D. I. (Daniel I.)
- Cheng Y.-C. (Yu-Ching)
- Chines P. S. (Peter S.)
- Chu A. Y. (Audrey Y.)
- Collins F. S. (Francis S.)
- Cornelis M. (Marilyn)
- Corre T. (Tanguy)
- Cucca F. (Francesco)
- Cupples L. A. (L. Adrienne)
- de Geus E. J. (Eco J. C.)
- De Moor M. H. (Marleen H. M.)
- Delgado G. E. (Graciela E.)
- Demirkan A. (Ayse)
- den Hoed M. (Marcel)
- Doerr M. (Marcus)
- Dueker N. (Nicole)
- Ebeling T. (Tapani)
- Eicher J. D. (John D.)
- Eiriksdottir G. (Gudny)
- Eriksson J. (Joel)
- Esko T. (Tonu)
- Faerch K. (Kristine)
- Faul J. D. (Jessica D.)
- Feitosa M. F. (Mary F.)
- Fornage M. (Myriam)
- Fox C. S. (Caroline S.)
- Franks P. W. (Paul W.)
- Frayling T. M. (Timothy M.)
- Froguel P. (Philippe)
- Fu M. (Mao)
- Gieger C. (Christian)
- Glaeser S. (Sven)
- Gong J. (Jian)
- Gordon-Larsen P. (Penny)
- Graff M. (Mariaelisa)
- Grallert H. (Harald)
- Grammer T. B. (Tanja B.)
- Grarup N. (Niels)
- Griffin P. J. (Paula J.)
- Gudnason V. (Vilmundur)
- Gyllensten U. (Ulf)
- Hadley D. (David)
- Haiman C. A. (Christopher A.)
- Haller T. (Toomas)
- Hallmans G. (Goran)
- Hansen T. (Torben)
- Harald K. (Kennet)
- Harder M. N. (Marie Neergaard)
- Harris T. B. (Tamara B.)
- Hartman C. A. (Catharina A.)
- Hassinen M. (Maija)
- Hastie N. D. (Nicholas D.)
- Havulinna A. S. (Aki S.)
- Hayes J. E. (James E.)
- Hayward C. (Caroline)
- Heard-Costa N. L. (Nancy L.)
- Heid I. M. (Iris M.)
- Hernandez D. (Dena)
- Hindorff L. (Lucia)
- Hirschhorn J. N. (Joel N.)
- Hocking L. J. (Lynne J.)
- Hofman A. (Albert)
- Hollensted M. (Mette)
- Holmens O. L. (Oddgeir L.)
- Holzapfel C. (Christina)
- Hottenga J. J. (Jouke Jan)
- Huang J. (Jie)
- Huang T. (Tao)
- Huffman J. E. (Jennifer E.)
- Hui J. (Jennie)
- Huppertz C. (Charlotte)
- Huth C. (Cornelia)
- Hutri-Kahonen N. (Nina)
- Hveem K. (Kristian)
- Jackson A. U. (Anne U.)
- James A. L. (Alan L.)
- Jansson J.-O. (John-Olov)
- Jarvelin M.-R. (Marjo-Riitta)
- Jhun M. A. (Min A.)
- Johansson A. (Asa)
- Johnson A. D. (Andrew D.)
- Juonala M. (Markus)
- Justesen J. M. (Johanne Marie)
- Justice A. E. (Anne E.)
- Kahonen M. (Mika)
- Kardia S. L. (Sharon L. R.)
- Kilpelainen T. O. (Tuomas O.)
- Kinnunen L. (Leena)
- Kivimaki M. (Mika)
- Kleber M. E. (Marcus E.)
- Klein R. J. (Robert J.)
- Koistinen H. A. (Heikki A.)
- Kolcic I. (Ivana)
- Komulainen P. (Pirjo)
- Kooner J. S. (Jaspal S.)
- Kooperberg C. (Charles)
- Kristiansson K. (Kati)
- Kuh D. (Diana)
- Kumari M. (Meena)
- Kutalik Z. (Zoltan)
- Kuusisto J. (Johanna)
- Kvaloy K. (Kirsti)
- Laakso M. (Markku)
- Lakka T. A. (Timo A.)
- Langenberg C. (Claudia)
- Launer L. J. (Lenore J.)
- Lehne B. (Benjamin)
- Lehtimaki T. (Terho)
- Lemarchand L. (Loic)
- Lim E. (Elise)
- Lim U. (Unhee)
- Lindgren C. M. (Cecilia M.)
- Linneberg A. (Allan)
- Liu C.-T. (Ching-Ti)
- Liu Y. (Yongmei)
- Lohman K. (Kurt)
- Loos R. J. (Ruth J. F.)
- Lorentzon M. (Mattias)
- Luan J. (Jian'an)
- Luben R. (Robert)
- Lyytikainen L.-P. (Leo-Pekka)
- Maerz W. (Winfried)
- Magl R. (Reedlk)
- Mahajan A. (Anubha)
- Mangino M. (Massimo)
- Mannikko R. (Reija)
- Mannisto S. (Satu)
- Marques-Vidal P. M. (Pedro M.)
- Marre M. (Michel)
- Marten J. (Jonathan)
- Martin N. G. (Nicholas G.)
- McCarthy M. I. (Mark I.)
- Metspalu A. (Andres)
- Milaneschi Y. (Yuri)
- Mohlke K. L. (Karen L.)
- Monda K. L. (Keri L.)
- Montgomery G. W. (Grant W.)
- Mueller-Nurasyid M. (Martina)
- Mulas A. (Antonella)
- Musk A. W. (A. W.)
- Narisu N. (Narisu)
- Nauck M. (Matthias)
- Navarro P. (Pau)
- Nettleton J. A. (Jennifer A.)
- Ngwa J. S. (Julius S.)
- Nolte I. M. (Ilja M.)
- North K. E. (Kari E.)
- O'Connell J. R. (Jeffrey R.)
- Ohlsson C. (Claes)
- Ohlsson C. (Claes)
- Oldehinkel A. J. (Albertine J.)
- Olden M. (Matthias)
- Ong K. K. (Ken K.)
- Padmanabhan S. (Sandosh)
- Palmer L. J. (Lyle J.)
- Pasko D. (Dorota)
- Paternoster L. (Lavinia)
- Pedersen O. (Oluf)
- Penninx B. W. (Brenda W. J. H.)
- Perez J. (Jeremiah)
- Perola M. (Markus)
- Perusse L. (Louis)
- Peters A. (Annette)
- Peters U. (Ulrike)
- Peyrot W. J. (Wouter J.)
- Peyser P. A. (Patricia A.)
- Polasek O. (Ozren)
- Porteous D. J. (David J.)
- Prokopenko I. (Inga)
- Puolijoki H. (Hannu)
- Qi L. (Lu)
- Qi Q. (Qibin)
- Quaye L. (Lydia)
- Raitakari O. T. (Olli T.)
- Rankinen T. (Tuomo)
- Rasmussen-Torvik L. J. (Laura J.)
- Rauramaa R. (Rainer)
- Rawal R. (Rajesh)
- Renstrom F. (Frida)
- Ridker P. M. (Paul M.)
- Rivadeneira F. (Fernando)
- Rivera N. V. (Natalia V.)
- Rose L. M. (Lynda M.)
- Rudan I. (Igor)
- Salomaa V. (Veikko)
- Sanna S. (Serena)
- Sarti C. (Cinzia)
- Sarzynski M. A. (Mark A.)
- Savonen K. (Kai)
- Scott R. A. (Robert A.)
- Scott W. R. (William R.)
- Shuldiner A. R. (Alan R.)
- Sidney S. (Steve)
- Silbernagel G. (Guenther)
- Smith A. V. (Albert Vernon)
- Smith B. H. (Blair H.)
- Smith G. D. (George Davey)
- Smith J. A. (Jennifer A.)
- Snieder H. (Harold)
- Snitker S. (Soren)
- Sorensen T. I. (Thorkild I. A.)
- Stancakova A. (Alena)
- Sternfeld B. (Barbara)
- Strachan D. P. (David P.)
- Strauch K. (Konstantin)
- Stringham H. M. (Heather M.)
- Swift A. J. (Amy J.)
- Tammelin T. (Tuija)
- Tan S.-T. (Sian-Tsung)
- Tanaka T. (Toshiko)
- Teumer A. (Alexander)
- Thorand B. (Barbara)
- Thuillier D. (Dorothee)
- Toenjes A. (Anke)
- Tuomilehto J. (Jaakko)
- Uitterlinden A. G. (Andre G.)
- Van der Most P. J. (Peter J.)
- van Duijn C. M. (Cornelia M.)
- van Grootheest G. (Gerard)
- van Vliet-Ostaptchouk J. V. (Jana V.)
- Vandenput L. (Liesbeth)
- Vestergaard H. (Henrik)
- Vitart V. (Veronique)
- Voelker U. (Uwe)
- Voelzke H. (Henry)
- Vohl M.-C. (Marie-Claude)
- Vollenweider P. (Peter)
- Waeber G. (Gerard)
- Walker M. (Mark)
- Wareham N. J. (Nicholas J.)
- Weir D. R. (David R.)
- Whitfield J. B. (John B.)
- Wild S. (Sarah)
- Willemsen G. (Gonneke)
- Wilson J. F. (James F.)
- Winkler T. W. (Thomas W.)
- Wong A. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A. F. (Alan F.)
- Wu Y. (Ying)
- Xue L. (Luting)
- Yengo L. (Loic)
- Young K. L. (Kristin L.)
- Zhang W. (Weihua)
- Zhao J. H. (Jing Hua)
- Zhao W. (Wei)
- Zillikens M. C. (M. Carola)
- Zubair N. (Niha)
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2017
- Field of study
Abstract
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery
Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
- Author
- Aadahl Mette
- Abecasis Goncalo R.
- Adair Linda S.
- Ahluwalia Tarunveer S.
- Ahmad Shafqat
- Amin Najaf
- Auvinen Juha
- Balkau Beverley
- Bandinelli Stefania
- Barata Llilda
- Barroso Ines
- Beilby John
- Bellis Claire
- Bergman Richard N.
- Bergmann Sven
- Bertoni Alain G.
- Bielak Lawrence F.
- Bien Stephanie
- Blangero John
- Boehnke Michael
- Boerwinkle Eric
- Bonnefond Amelle
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Borja Judith B.
- Bouchard Claude
- Brage Soren
- Bragg-Gresham Jennifer L.
- Busonero Fabio
- Buyske Steve
- Cadby Gemma
- Campbell Harry
- Chambers John C.
- Chasman Daniel I.
- Cheng Yu-Ching
- Chines Peter S.
- Chu Audrey Y.
- Collins Francis S.
- Cornelis Marilyn
- Corre Tanguy
- Cucca Francesco
- Cupples L. Adrienne
- de Geus Eco J. C.
- De Moor Marleen H. M.
- Delgado Graciela E.
- Demirkan Ayse
- den Hoed Marcel
- Doerr Marcus
- Dueker Nicole
- Ebeling Tapani
- Eicher John D.
- Eiriksdottir Gudny
- Eriksson Joel
- Esko Tonu
- Faerch Kristine
- Faul Jessica D.
- Feitosa Mary F.
- Fornage Myriam
- Fox Caroline S.
- Franks Paul W.
- Frayling Timothy M.
- Froguel Philippe
- Fu Mao
- Gieger Christian
- Glaeser Sven
- Gong Jian
- Gordon-Larsen Penny
- Graff Mariaelisa
- Grallert Harald
- Grammer Tanja B.
- Grarup Niels
- Griffin Paula J.
- Gudnason Vilmundur
- Gyllensten Ulf
- Hadley David
- Haiman Christopher A.
- Haller Toomas
- Hallmans Goran
- Hansen Torben
- Harald Kennet
- Harder Marie Neergaard
- Harris Tamara B.
- Hartman Catharina A.
- Hassinen Maija
- Hastie Nicholas D.
- Havulinna Aki S.
- Hayes James E.
- Hayward Caroline
- Heard-Costa Nancy L.
- Heid Iris M.
- Hernandez Dena
- Hindorff Lucia
- Hirschhorn Joel N.
- Hocking Lynne J.
- Hofman Albert
- Hollensted Mette
- Holmens Oddgeir L.
- Holzapfel Christina
- Hottenga Jouke Jan
- Huang Jie
- Huang Tao
- Huffman Jennifer E.
- Hui Jennie
- Huppertz Charlotte
- Huth Cornelia
- Hutri-Kahonen Nina
- Hveem Kristian
- Jackson Anne U.
- James Alan L.
- Jansson John-Olov
- Jarvelin Marjo-Riitta
- Jhun Min A.
- Johansson Asa
- Johnson Andrew D.
- Juonala Markus
- Justesen Johanne Marie
- Justice Anne E.
- Kahonen Mika
- Kardia Sharon L. R.
- Kilpelainen Tuomas O.
- Kinnunen Leena
- Kivimaki Mika
- Kleber Marcus E.
- Klein Robert J.
- Koistinen Heikki A.
- Kolcic Ivana
- Komulainen Pirjo
- Kooner Jaspal S.
- Kooperberg Charles
- Kristiansson Kati
- Kuh Diana
- Kumari Meena
- Kutalik Zoltan
- Kuusisto Johanna
- Kvaloy Kirsti
- Laakso Markku
- Lakka Timo A.
- Langenberg Claudia
- Launer Lenore J.
- Lehne Benjamin
- Lehtimaki Terho
- Lemarchand Loic
- Lim Elise
- Lim Unhee
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Liu Yongmei
- Lohman Kurt
- Loos Ruth J. F.
- Lorentzon Mattias
- Luan Jian'an
- Luben Robert
- Lyytikainen Leo-Pekka
- Maerz Winfried
- Magl Reedlk
- Mahajan Anubha
- Mangino Massimo
- Mannikko Reija
- Mannisto Satu
- Marques-Vidal Pedro M.
- Marre Michel
- Marten Jonathan
- Martin Nicholas G.
- McCarthy Mark I.
- Metspalu Andres
- Milaneschi Yuri
- Mohlke Karen L.
- Monda Keri L.
- Montgomery Grant W.
- Mueller-Nurasyid Martina
- Mulas Antonella
- Musk A. W.
- Narisu Narisu
- Nauck Matthias
- Navarro Pau
- Nettleton Jennifer A.
- Ngwa Julius S.
- Nolte Ilja M.
- North Kari E.
- O'Connell Jeffrey R.
- Ohlsson Claes
- Ohlsson Claes
- Oldehinkel Albertine J.
- Olden Matthias
- Ong Ken K.
- Padmanabhan Sandosh
- Palmer Lyle J.
- Pasko Dorota
- Paternoster Lavinia
- Pedersen Oluf
- Penninx Brenda W. J. H.
- Perez Jeremiah
- Perola Markus
- Perusse Louis
- Peters Annette
- Peters Ulrike
- Peyrot Wouter J.
- Peyser Patricia A.
- Polasek Ozren
- Porteous David J.
- Prokopenko Inga
- Puolijoki Hannu
- Qi Lu
- Qi Qibin
- Quaye Lydia
- Raitakari Olli T.
- Rankinen Tuomo
- Rasmussen-Torvik Laura J.
- Rauramaa Rainer
- Rawal Rajesh
- Renstrom Frida
- Ridker Paul M.
- Rivadeneira Fernando
- Rivera Natalia V.
- Rose Lynda M.
- Rudan Igor
- Salomaa Veikko
- Sanna Serena
- Sarti Cinzia
- Sarzynski Mark A.
- Savonen Kai
- Scott Robert A.
- Scott William R.
- Shuldiner Alan R.
- Sidney Steve
- Silbernagel Guenther
- Smith Albert Vernon
- Smith Blair H.
- Smith George Davey
- Smith Jennifer A.
- Snieder Harold
- Snitker Soren
- Sorensen Thorkild I. A.
- Stancakova Alena
- Sternfeld Barbara
- Strachan David P.
- Strauch Konstantin
- Stringham Heather M.
- Swift Amy J.
- Tammelin Tuija
- Tan Sian-Tsung
- Tanaka Toshiko
- Teumer Alexander
- Thorand Barbara
- Thuillier Dorothee
- Toenjes Anke
- Tuomilehto Jaakko
- Uitterlinden Andre G.
- Van der Most Peter J.
- van Duijn Cornelia M.
- van Grootheest Gerard
- van Vliet-Ostaptchouk Jana V.
- Vandenput Liesbeth
- Vestergaard Henrik
- Vitart Veronique
- Voelker Uwe
- Voelzke Henry
- Vohl Marie-Claude
- Vollenweider Peter
- Waeber Gerard
- Walker Mark
- Wareham Nicholas J.
- Weir David R.
- Whitfield John B.
- Wild Sarah
- Willemsen Gonneke
- Wilson James F.
- Winkler Thomas W.
- Wong Andrew
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wu Ying
- Xue Luting
- Yengo Loic
- Young Kristin L.
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zillikens M. Carola
- Zubair Niha
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study