The Trace Anomaly and the Gravitational Coupling of an Anomalous U(1)

We extend a previous computation of the TJJ correlator, involving the energy-momentum tensor of an abelian gauge theory and two vector currents, to the case of mixed axial-vector/vector currents. The study is performed in analogy to the case of the $AVV$ vertex for the chiral anomaly. We derive the general structure of the anomalous Ward identities and provide explicit tests of their consistency using Dimensional Reduction. Mixed massive correlators of the form $TJ_V J_A$ are shown to vanish both by Ward identities and by C-invariance. The result is characterized by the appearance of massless scalar degrees of freedom in the coupling of chiral and vector theories to gravity, affecting both the soft and the ultraviolet region of the vertex. This is in agreement with previous studies of the effective action of gauge and conformal anomalies in QED and QCD.Comment: 30 pages, 3 figure

Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats.

AIMS/HYPOTHESIS: Diabetes is considered the leading cause of neuropathies in developed countries. Dysfunction of nerve growth factor (NGF) production and/or utilisation may lead to the establishment of diabetic neuropathies. Electroacupuncture has been proved effective in the treatment of human neuropathic pain as well as in modulating NGF production/activity. We aimed at using electroacupuncture to correct the development of thermal hyperalgesia and the tissue alteration of NGF and sensory neuromodulators in a rat model of type 1 diabetes. METHODS: Adult rats were injected with streptozotocin to induce diabetes and subsequently treated with low-frequency electroacupuncture for 3 weeks. Variation in thermal sensitivity was studied during the experimental course. Hindpaw skin and spinal cord protein content of NGF, NGF receptor tyrosine kinase A (TrkA), substance P (SP), transient receptor potential vanilloid 1 (TRPV1) receptor and glutamic acid decarboxylase-67 (GAD-67) were measured after electroacupuncture treatments. The skin and spinal cord cellular distribution of TrkA was analysed to explore NGF signalling. RESULTS: Early after streptozotocin treatment, thermal hyperalgesia developed that was corrected by electroacupuncture. The parallel increases in NGF and TrkA in the spinal cord were counteracted by electroacupuncture. Streptozotocin also induced variation in skin/spinal TrkA phosphorylation, increases in skin SP and spinal TRPV1 and a decrease in spinal GAD-67. These changes were counteracted by electroacupuncture. CONCLUSIONS/INTERPRETATION: Our results point to the potential of electroacupuncture as a supportive therapy for the treatment of diabetic neuropathies. The efficacy of electroacupuncture might depend on its actions on spinal/peripheral NGF synthesis/utilisation and normalisation of the levels of several sensory neuromodulators

Effect of electro-acupuncture on ovarian expression of α (1)- and β (2)-adrenoceptors, and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries

BACKGROUND: Estradiol valerate (EV)-induced polycystic ovaries (PCO) in rats is associated with an increase in ovarian sympathetic outflow. Low-frequency (2 Hz) electro-acupuncture (EA) has been shown to modulate sympathetic markers as well as ovarian blood flow as a reflex response via the ovarian sympathetic nerves, in rats with EV-induced PCO. METHODS: In the present study, we further tested the hypothesis that repeated 2 Hz EA treatments modulate ovarian sympathetic outflow in rats with PCO, induced by a single i.m. injection of EV, by investigating the mRNA expression, the amount and distribution of proteins of α1a-, α1b-, α1d-, and β2-adrenoceptors (ARs), as well as the low-affinity neurotrophin receptor (p75NTR). RESULTS: It was found that EV injection results in significantly higher mRNA expression of ovarian α1b- and α1d-AR in PCO rats compared to control rats. The p75NTR and β2-ARs mRNA expression were unchanged in the PCO ovary. Low-frequency EA resulted in a significantly lower expression of β2-ARs mRNA expression in PCO rats. The p75NTR mRNA was unaffected in both PCO and control rats. PCO ovaries displayed significantly higher amount of protein of α1a-, α1b- and α1d-ARs, and of p75NTR, compared to control rats, that were all counteracted by repeated low-frequency EA treatments, except for α1b-AR. CONCLUSION: The present study shows that EA normalizes most of the EV-induced changes in ovarian ARs. Furthermore, EA was able to prevent the EV-induced up regulation of p75NTR, probably by normalizing the sympathetic ovarian response to NGF action. Our data indicate a possible role of EA in the regulation of ovarian responsiveness to sympathetic inputs and depict a possible complementary therapeutic approach to overcoming sympathetic-related anovulation in women with PCOS

Il modello di prevenzione ad alta affidabilità per la gestione delle crisi: la consapevolezza nella gestione dei rischi in uno studio di caso

The measurement of the attitude of individuals about the concepts involved in mindfulness was carried out through nine scales proposed by Weick and Sutcliffe (2001, 2007), each one of which being constituted by a different number of items, ranging from seven to twelve items. The questionnaire containing the nine scales was administered to four establishments of a selected firm, with 103 respondents. The evaluation of each score for each section, classified in three categories (Low, Median, and Optimal), followed different criteria: location with respect to the corresponding thresholds, and the concentration and dispersion of scores in the optimal category. The evaluation of the performance of each scale was carried out considering: its internal consistency through the Cronbach’s alpha, the distribution of the scores in response categories with respect to the direction of the scale, semantic analysis of items to ascertain coherence with the polarity of the scale. The data analysis revealed some critical items in various sections and suggested further studies and applications to ascertain their foundation, stability, and robustness. Another observation concerned a different set of options for the items: a self-anchoring Likert scale for the sections S1, S2, S4, S5, and S7-S9, a classical Likert scale for sections S3 and S6

Steroid-induced polycystic ovaries in rats: effect of electro-acupuncture on concentrations of endothelin-1 and nerve growth factor (NGF), and expression of NGF mRNA in the ovaries, the adrenal glands, and the central nervous system

Previous studies on the effect of repeated electro-acupuncture (EA) treatments in rats with steriod-induced polycystic ovaries (PCO), EA has been shown to modulate nerve growth factor (NGF) concentration in the ovaries as well as corticotropin releasing factor (CRF) in the median eminence (ME). In the present study we tested the hypothesis that repeated EA treatments modulates sympathetic nerve activity in rats with PCO. This was done by analysing endothelin-1 (ET-1), a potent vasoconstrictor involved in ovarian functions, as well as NGF and NGF mRNA expression involved in the pathophysiological process underlying steroid-induced PCO. The main result in the present study was that concentrations of ET-1 in the ovaries were significantly lower in the PCO group receiving EA compared with the healthy control group (p < 0.05). In the hypothalamus, however, ET-1 concentrations were found to be significantly higher in the PCO group receiving EA than in the healthy control group (p < 0.05). Concentrations of ovarian NGF protein were significantly higher in the PCO control group compared with the healthy control group (p < 0.001), and these concentrations decreased significantly after repeated EA treatments compared with those in the PCO control group (p < 0.05) and were found to be the same as those in the healthy control group. In conclusion, these results indicate that EA modulates the neuroendocrinological state of the ovaries, most likely by modulating the sympathetic nerve activity in the ovaries, which may be a factor in the maintenance of steroid-induced PCO

The puzzling source IGR J17361-4441 in NGC 6388: a possible planetary tidal disruption event

On 2011 August 11, INTEGRAL discovered the hard X-ray source IGR J17361-4441 near the centre of the globular cluster NGC 6388. Follow up observations with Chandra showed the position of the transient was inconsistent with the cluster dynamical centre, and thus not related to its possible intermediate mass black hole. The source showed a peculiar hard spectrum (Gamma \approx 0.8) and no evidence of QPOs, pulsations, type-I bursts, or radio emission. Based on its peak luminosity, IGR J17361-4441 was classified as a very faint X-ray transient, and most likely a low-mass X-ray binary. We re-analysed 200 days of Swift/XRT observations, covering the whole outburst of IGR J17361-4441 and find a t^{-5/3} trend evident in the light curve, and a thermal emission component that does not evolve significantly with time. We investigate whether this source could be a tidal disruption event, and for certain assumptions find an accretion efficiency epsilon \approx 3.5E-04 (M_{Ch}/M) consistent with a massive white dwarf, and a disrupted minor body mass M_{mb}=1.9E+27(M/M_{Ch}) g in the terrestrial-icy planet regime. These numbers yield an inner disc temperature of the order kT_{in} \approx 0.04 keV, consistent with the blackbody temperature of kT_{in} \approx 0.08 keV estimated by spectral fitting. Although the density of white dwarfs and the number of free-floating planets are uncertain, we estimate the rate of planetary tidal disruptions in NGC 6388 to be in the range 3E-06 to 3E-04 yr^{-1}. Averaged over the Milky Way globular clusters, the upper limit value corresponds to 0.05 yr^{-1}, consistent with the observation of a single event by INTEGRAL and Swift.Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journal on 2014 July 16; 9 pages, 5 figures. Added references; corrected typo

Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats

The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells. The development and progression of diabetes generate a mild cognitive impairment reducing the functions of the septo-hippocampal cholinergic circuitry, depressing neural plasticity and inducing proNGF accumulation in the brain. Here we demonstrate, in a rat model of early type-1 diabetes, that a physical therapy, the electroacupuncture, counteracts the diabetes-induced deleterious effects on hippocampal physiology by ameliorating hippocampal-related memory functions; recovering the impaired long-term potentiation at the dentate gyrus (DG-LTP) and the lowered expression of the vesicular glutamate transporter 1; normalizing the activity-dependent release of proNGF in diabetic rat hippocampus. Electroacupuncture exerted its therapeutic effects by regulating the expression and activity of M1- and M2-acetylcholine muscarinic receptors subtypes in the dentate gyrus of hippocampus. Our results suggest that a physical therapy based on repetitive sensory stimulation could promote hippocampal neural activity, neuronal metabolism and functions, and conceivably improve the diabetes-induced cognitive impairment. Our data can support the setup of therapeutic protocols based on a better integration between physical therapies and pharmacology for the cure of diabetes-associated neurodegeneration and possibly for Alzheimer's disease

PAAT: a path to atherosclerosis

The artery wall consists ofintima, media, and adventitia, the latter gradually transiting into the periadventitial adipose tissue (PAAT). Although many paths lead to atherosclerosis, the prevailing paradigm at present is Russell Ross's response-to-injury hypothesis, which states that atherosclerosis is a chronic inflammatory disease. This hypothesis considers the intimal smooth muscle cell proliferation as a key event in the generation, development and complication of atherosclerosis. Thus the potentially important role played by adventitial fibroblasts/myofibroblasts in atherosclerosis and postangioplasty restenosis, suggesting therapeutic perspectives targeted to these particular cells, has been neglected. Here we go further away from the intima, and focus on the potential involvement of PAAT in the process of atherogenesis and angioplasty-induced restenosis.Biomedical Reviews 2002; 13: 63-65

ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints. A novel pathogenic mechanism in chronic arthritis

To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis inflammatio

Strategies for a Positive Anthropogenic Impact in Postwar Buildings

A significant portion of postwar buildings, typically concentrated in suburban areas, are now difficult assets to manage due to their poor sustainability and limited replacement feasibilities. This paper focuses on strategies to improve their metabolism using energy-saving measures based on optimizing energy needs and integrating internal and external energy sources: a new organizational model for energy management should focus first on saving energy, and then on the possibility of integration into a local energy network. This positively affects the anthropogenic impact and becomes a role model for aggregating buildings not only into a district system, but also into a wider, large-scale energy network. The paper shows a significant case study of actual retrofitting intervention that is examined in order to confirm the theoretical guidelines proposed in the first part of the paper. Moreover, another significant case study, taken from common practice, is illustrated, in which different levels of retrofitting are tested. While taking into account the complexity and fragmentation of private property both in a single building and in the city, some strategies are finally described with the aim of reducing the anthropic impact of the postwar building stock