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Low Incidence of Chest Wall Pain with a Risk-Adapted Lung Stereotactic Body Radiation Therapy Approach Using Three or Five Fractions Based on Chest Wall Dosimetry
Purpose To examine the frequency and potential of dose-volume predictors for chest wall (CW) toxicity (pain and/or rib fracture) for patients receiving lung stereotactic body radiotherapy (SBRT) using treatment planning methods to minimize CW dose and a risk-adapted fractionation scheme. Methods: We reviewed data from 72 treatment plans, from 69 lung SBRT patients with at least one year of follow-up or CW toxicity, who were treated at our center between 2010 and 2013. Treatment plans were optimized to reduce CW dose and patients received a risk-adapted fractionation of 18 Gy×3 fractions (54 Gy total) if the CW V30 was less than 30 mL or 10–12 Gy×5 fractions (50–60 Gy total) otherwise. The association between CW toxicity and patient characteristics, treatment parameters and dose metrics, including biologically equivalent dose, were analyzed using logistic regression. Results: With a median follow-up of 20 months, 6 (8.3%) patients developed CW pain including three (4.2%) grade 1, two (2.8%) grade 2 and one (1.4%) grade 3. Five (6.9%) patients developed rib fractures, one of which was symptomatic. No significant associations between CW toxicity and patient and dosimetric variables were identified on univariate nor multivariate analysis. Conclusions: Optimization of treatment plans to reduce CW dose and a risk-adapted fractionation strategy of three or five fractions based on the CW V30 resulted in a low incidence of CW toxicity. Under these conditions, none of the patient characteristics or dose metrics we examined appeared to be predictive of CW pain
Chest wall and planning target volume (PTV) contour, in blue and red respectively.
<p>Chest wall and planning target volume (PTV) contour, in blue and red respectively.</p
Comparison of CW toxicity from our study versus previously reported studies.
<p>*Not described in the paper.</p
CTCAEv.4 chest wall pain toxicity scale and modified chest wall toxicity scale used in the current report.
<p>CTCAEv.4 chest wall pain toxicity scale and modified chest wall toxicity scale used in the current report.</p
Incidence of Chest Wall Toxicities for 72 peripheral lung SBRT treatment plans.
<p>*Grade 2 pain.</p
Tumor Characteristics and Dosimetry Metrics.
<p>Tumor Characteristics and Dosimetry Metrics.</p