60 research outputs found
Treatment with 1,25-dihydroxyvitamin D3 preserves glomerular slit diaphragm-associated protein expression in experimental glomerulonephritis
In this study, we investigated the effect of 1,25(OH)2D3on proteinuria and on the alteration of slit diaphragm-associated proteins induced by anti-Thy 1.1 in Wistar rats. Four groups of animals were studied: group I, anti-Thy 1.1 treated rats; group II, anti-Thy1.1 treated group that at day 2, after the onset of overt proteinuria, started the treatment with 1,25(OH)2D3; group III, normal control rats injected with vehicle alone; group IV, rats that received only 1,25(OH)2D3. At day 2, in group I and II, before the administration of 1,25(OH)2D3, protein excretion was significantly increased when compared to controls. Overt proteinuria was maintained until day 14 in group I whereas in group II protein excretion was significantly reduced from day 3 to day 14. Moreover, treatment with 1,25(OH)2D3abrogated podocytes injury, detected as desmin expression and loss of nephrin and zonula occludens-1 (ZO-1), two slit diaphragm-associated proteins, and glomerular polyanion staining, that were observed in group I. In conclusion, these results suggest that 1,25(OH)2D3administrated with a therapeutic regiment may revert proteinuria, counteracting glomerular podocyte injury
Bulk experimental evidence of half-metallic ferromagnetism in doped manganites
We report precise measurements and quantitative data analysis on the
low-temperature resistivity of several ferromagnetic manganite films. We
clearly show that there exists a T^{4.5} term in low-temperature resistivity,
and that this term is in quantitative agreement with the quantum theory of
two-magnon scattering for half metallic ferromagnets. Our present results
provide the first bulk experimental evidence of half-metallic ferromagnetism in
doped manganites.Comment: 4 pages, 4 figure
Low-temperature electrical transport and double exchange in La(Pb,Ca)MnO
The resistivity in the ferromagnetic state of flux-grown
La_{2/3}(Pb,Ca)_{1/3}MnO_3 single crystals, measured in magnetic fields up to 7
T, reveals a strong quadratic temperature dependence at and above 50 K. At
lower temperatures, this contribution drops precipitously leaving the
resistivity essentially temperature independent below 20 K. The Seebeck
coefficient also reflects a change of regime at the same temperature. We
attribute this behavior to a cut-off of single magnon scattering processes at
long wavelengths due to the polarized bands of a double-exchange ferromagnet.Comment: 10 pages, TeX, 4 figures. Revised version. Submitte
Unusual behaviors in the transport properties of REFeP (RE: La, Ce, Pr, and Nd)
We have investigated the resistivity (), thermoelectric power (TEP) and
Hall coefficient () on high quality single crystals of
REFeP. TEP in CeFeP is extremely large (
0.5mV/K at 290K) with a peak of 0.75mV/K at around 65K. The Hall
mobility also shows a peak at 65K, suggesting carriers with heavy masses
developed at lower temperatures related with the f-hybridized band. Both Pr-
and Nd- systems exhibit an apparent increase of with decreasing
temperature far above their magnetic transition temperatures. In the same
temperature ranges, TEP exhibits unusually large absolute values of -50V/K
for PrFeP and -15V/K for NdFeP, respectively.
For PrFeP, such anomalous transport properties suggest an unusual
ground state, possibly related with the Quadrupolar Kondo effect.Comment: 5 pages, 8 figure
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Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding
The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes with RUNX1 function. The result of this interference is a block in differentiation and, finally, the development of acute myeloid leukemia (AML). To obtain insights into RUNX1/ETO-dependant alterations of the epigenetic landscape, we measured genome-wide RUNX1- and RUNX1/ETO-bound regions in t(8;21) cells and assessed to what extent the effects of RUNX1/ETO on the epigenome depend on its continued expression in established leukemic cells. To this end, we determined dynamic alterations of histone acetylation, RNA Polymerase II binding and RUNX1 occupancy in the presence or absence of RUNX1/ETO using a knockdown approach. Combined global assessments of chromatin accessibility and kinetic gene expression data show that RUNX1/ETO controls the expression of important regulators of hematopoietic differentiation and self-renewal. We show that selective removal of RUNX1/ETO leads to a widespread reversal of epigenetic reprogramming and a genome-wide redistribution of RUNX1 binding, resulting in the inhibition of leukemic proliferation and self-renewal, and the induction of differentiation. This demonstrates that RUNX1/ETO represents a pivotal therapeutic target in AML
Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding
The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes with RUNX1 function. The result of this interference is a block in differentiation and, finally, the development of acute myeloid leukemia (AML). To obtain insights into RUNX1/ETO-dependant alterations of the epigenetic landscape, we measured genome-wide RUNX1- and RUNX1/ETO-bound regions in t(8;21) cells and assessed to what extent the effects of RUNX1/ETO on the epigenome depend on its continued expression in established leukemic cells. To this end, we determined dynamic alterations of histone acetylation, RNA Polymerase II binding and RUNX1 occupancy in the presence or absence of RUNX1/ETO using a knockdown approach. Combined global assessments of chromatin accessibility and kinetic gene expression data show that RUNX1/ETO controls the expression of important regulators of hematopoietic differentiation and self-renewal. We show that selective removal of RUNX1/ETO leads to a widespread reversal of epigenetic reprogramming and a genome-wide redistribution of RUNX1 binding, resulting in the inhibition of leukemic proliferation and self-renewal, and the induction of differentiation. This demonstrates that RUNX1/ETO represents a pivotal therapeutic target in AML
Elliptic integral evaluations of Bessel moments
We record what is known about the closed forms for various Bessel function
moments arising in quantum field theory, condensed matter theory and other
parts of mathematical physics. More generally, we develop formulae for
integrals of products of six or fewer Bessel functions. In consequence, we are
able to discover and prove closed forms for with integers and , obtaining new results
for the even moments and . We also derive new closed forms
for the odd moments with and for with , relating the latter to Green functions on
hexagonal, diamond and cubic lattices. We conjecture the values of
, make substantial progress on the evaluation of ,
and and report more limited progress regarding
, and . In the process, we obtain 8
conjectural evaluations, each of which has been checked to 1200 decimal places.
One of these lies deep in 4- dimensional quantum field theory and two are
probably provable by delicate combinatorics. There remains a hard core of five
conjectures whose proofs would be most instructive, to mathematicians and
physicists alike.Comment: 51 pages, 1 Postscript figure, uses amsmath.sty, added reference
Exchange Interaction between Conduction Electrons and Magnetic Shell Electrons in Rare-Earth Metals
The interaction Hamiltonian for the Coulomb exchange effect between conduction electrons and magnetic-shell electrons in rare-earth metals was derived from first principles. The approximations under which the interaction can be represented by the product of electron and ion spin vectors are exhibited. (auth
Differential BDNF Responses of Triple Versus Dual Reuptake Inhibition in Neuronal and Astrocytoma Cells as well as in Rat Hippocampus and Prefrontal Cortex
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