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Introduction
The articles in this issue are drawn from the papers delivered at the conference âAb Initio: Law in Early America,â held in Philadelphia on June 16â17, 2010âthe first conference in nearly fifteen years to focus on law in early America. It was sponsored by the Penn Legal History Consortium, the McNeil Center for Early American Studies, the American Society for Legal History, the University of Michigan Law School, and the University of Minnesota Law School, under the direction of Sarah Barringer Gordon, Martha S. Jones, William J. Novak, Daniel K. Richter, Richard J. Ross, and Barbara Y. Welke. For two days, fifteen mostly younger scholars presented their research to a packed house, with formal comments by senior scholars and vigorous discussion with the audience. That earlier conference, âThe Many Legalities of Early America,â which convened in Williamsburg in 1996, had illustrated the shift from what was once trumpeted as the ânewâ legal history to something that never acquired a name, perhaps because it was less self-conscious in its methodology. âAb Initioâ offered the opportunity to ask how the field has changed in the years since
Book Review: Decision in Philadelphia: The Constitutional Convention of 1787. Christopher Collier and James Lincoln Collier; the First Amendment: The Legacy of George Mason. Edited by T. Daniel Shumate.
Book review: Decision in Philadelphia: The Constitutional Convention of 1787. Christopher Collier and James Lincoln Collier. New York, N.Y.: Random House/Reader\u27s Digest Press. 1986. Pp. xvi, 331 ; The First Amendment: The Legacy of George Mason. Edited by T. Daniel Shumate. Fairfax, Va.: George Mason University Press. 1985. Pp. 201. Reviewed by: Bruce H Mann
Law, Legalism, and Community Before the American Revolution
The connections between law and community are difficult to identify, let alone explain. It may be best to begin by seeing how law and the ways people used it changed, and then attempt to relate those changes to the surrounding economy and society. One must, of course, be wary of finding what one looks for. Nonetheless, as with objects against a dark background, it is sometimes easier to see things when they move than when they remain still. To illustrate the interactive nature of legal change and community, I will draw on examples from Connecticut before the Revolution - not because I think Connecticut was representative or typical, but because I know something about it. As it happens, there were significant changes in the legal system from the end of the seventeenth century to the eve of the Revolution, both in the ways people used the legal system and in its internal characteristics. There were also perceptible changes in the economy and society of the colony during the same period. The juxtaposition may have been coincidental, but I think not. The changes were linked, however loosely, by the growth of a legalist paradigm, in which the formal legal system supplanted ways of dealing that were rooted in communities and became the standards for all forms of disputing
Book Review: Decision in Philadelphia: The Constitutional Convention of 1787. Christopher Collier and James Lincoln Collier; the First Amendment: The Legacy of George Mason. Edited by T. Daniel Shumate.
Book review: Decision in Philadelphia: The Constitutional Convention of 1787. Christopher Collier and James Lincoln Collier. New York, N.Y.: Random House/Reader\u27s Digest Press. 1986. Pp. xvi, 331 ; The First Amendment: The Legacy of George Mason. Edited by T. Daniel Shumate. Fairfax, Va.: George Mason University Press. 1985. Pp. 201. Reviewed by: Bruce H Mann
Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers.
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands out among the other NTDs due to its broad and significant impact on both human and animal health, as Fasciola sp., are also considered major pathogens of domesticated ruminants. Here we present a reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, complementing previously reported isolate from cattle. A total of 14,642 genes were predicted from the 1.14 GB genome of the liver fluke. Comparative genomics indicated that F. hepatica Oregon and related food-borne trematodes are metabolically less constrained than schistosomes and cestodes, taking advantage of the richer millieux offered by the hepatobiliary organs. Protease families differentially expanded between diverse trematodes may facilitate migration and survival within the heterogeneous environments and niches within the mammalian host. Surprisingly, the sequencing of Oregon and Uruguay F. hepatica isolates led to the first discovery of an endobacteria in this species. Two contigs from the F. hepatica Oregon assembly were joined to complete the 859,205 bp genome of a novel Neorickettsia endobacterium (nFh) closely related to the etiological agents of human Sennetsu and Potomac horse fevers. Immunohistochemical studies targeting a Neorickettsia surface protein found nFh in specific organs and tissues of the adult trematode including the female reproductive tract, eggs, the Mehlis\u27 gland, seminal vesicle, and oral suckers, suggesting putative routes for fluke-to-fluke and fluke-to-host transmission. The genomes of F. hepatica and nFh will serve as a resource for further exploration of the biology of F. hepatica, and specifically its newly discovered trans-kingdom interaction with nFh and the impact of both species on disease in ruminants and humans
Delays in Leniency Application: Is There Really a Race to the Enforcer's Door?
This paper studies cartelsâ strategic behavior in delaying leniency applications, a take-up decision that has been ignored in the previous literature. Using European Commission decisions issued over a 16-year span, we show, contrary to common beliefs and the existing literature, that conspirators
often apply for leniency long after a cartel collapses. We estimate hazard and probit models to study the determinants of leniency-application delays. Statistical tests find that delays are symmetrically affected by antitrust policies and macroeconomic fluctuations. Our results shed light on the design of
enforcement programs against cartels and other forms of conspiracy
Phenomenology and Cosmology of an Electroweak Pseudo-Dilaton and Electroweak Baryons
In many strongly-interacting models of electroweak symmetry breaking the
lowest-lying observable particle is a pseudo-Goldstone boson of approximate
scale symmetry, the pseudo-dilaton. Its interactions with Standard Model
particles can be described using a low-energy effective nonlinear chiral
Lagrangian supplemented by terms that restore approximate scale symmetry,
yielding couplings of the pseudo-dilaton that differ from those of a Standard
Model Higgs boson by fixed factors. We review the experimental constraints on
such a pseudo-dilaton in light of new data from the LHC and elsewhere. The
effective nonlinear chiral Lagrangian has Skyrmion solutions that may be
identified with the `electroweak baryons' of the underlying
strongly-interacting theory, whose nature may be revealed by the properties of
the Skyrmions. We discuss the finite-temperature electroweak phase transition
in the low-energy effective theory, finding that the possibility of a
first-order electroweak phase transition is resurrected. We discuss the
evolution of the Universe during this transition and derive an
order-of-magnitude lower limit on the abundance of electroweak baryons in the
absence of a cosmological asymmetry, which suggests that such an asymmetry
would be necessary if the electroweak baryons are to provide the cosmological
density of dark matter. We revisit estimates of the corresponding
spin-independent dark matter scattering cross section, with a view to direct
detection experiments.Comment: 34 pages, 4 figures, additional references adde
Inhibition of Progenitor Dendritic Cell Maturation by Plasma from Patients with Peripartum Cardiomyopathy: Role in Pregnancy-associated Heart Disease
Dendritic cells (DCs) play dual roles in innate and adaptive immunity based
on their functional maturity, and both innate and adaptive immune responses have
been implicated in myocardial tissue remodeling associated with
cardiomyopathies. Peripartum cardiomyopathy (PPCM) is a rare disorder which
affects women within one month antepartum to five months postpartum. A high
occurrence of PPCM in central Haiti (1 in 300 live births) provided the unique
opportunity to study the relationship of immune activation and DC maturation
to the etiology of this disorder. Plasma samples from two groups (n = 12) of
age- and parity-matched Haitian women with or without evidence of PPCM were
tested for levels of biomarkers of cardiac tissue remodeling and immune
activation. Significantly elevated levels of GM-CSF, endothelin-1, proBNP and
CRP and decreased levels of TGF- were measured in PPCM subjects relative
to controls. Yet despite these findings, in vitro maturation of normal human
cord blood derived progenitor dendritic cells (CBDCs) was significantly
reduced (p < 0.001) in the presence of plasma from PPCM patients relative
to plasma from post-partum control subjects as determined by expression of
CD80, CD86, CD83, CCR7, MHC class II and the ability of these matured CBDCs
to induce allo-responses in PBMCs. These results represent the first findings
linking inhibition of DC maturation to the dysregulation of normal physiologic
cardiac
tissue remodeling during pregnancy and the pathogenesis of PPCM
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