Teaching for learning with technology: a faculty development initiative at a research university

This paper reviews recent literature addressing the state of technology in higher education as a backdrop for a faculty development program offered annually at Northwestern. First, we will present the state of technology related to teaching in three areas: (1) the varied institutional interest in technology, (2) the variance in faculty engagement with technology, and (3) factors that influence faculty acceptance of technology. Next, we will introduce Northwestern’s response to the need for faculty development related to technology, the 5-day Teaching and Learning with Technology workshop. Finally, we will present data gathered over two years that demonstrates how pedagogically-driven technology training can enhance teaching and encourage faculty to embrace technology in teaching to accomplish pedagogically-based learning objectives

Dissecting Motor Neuron Disease With Drosophila melanogaster

Motor Neuron Disease (MND) typically affects patients during the later stages of life, and thus, MND is having an increasingly devastating impact on diagnosed individuals, their families and society. The umbrella term MND refers to diseases which cause the progressive loss of upper and/or lower motor neurons and a subsequent decrease in motor ability such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). The study of these diseases is complex and has recently involved the use of genome-wide association studies (GWAS). However, in the case of MND, it has been difficult to identify the complex genetics involved in subtypes, and functional investigation of new candidate disease genes is warranted. Drosophila is a powerful model for addressing these complex diseases. The UAS/Gal4/Gal80 system allows for the upregulation of Drosophila genes, the “knockdown” of genes and the ectopic expression of human genes or mutations in a tissue-specific manner; often resulting in Drosophila models which exhibit typical MND disease pathologies. These can then be further interrogated to identify disease-modifying genes or mutations and disease pathways. This review will discuss two common MNDs and the current Drosophila models which are being used to research their genetic basis and the different pathologies of MND

A Systematic Review of the Cost-Effectiveness of Chemotherapy Regimens

Background: The rising cost of chemotherapy dramatically increases the burden on healthcare and presents new challenges in achieving optimal patient outcomes. New treatments, in general, are more specialized but show minor progress in regards to efficacy. Accordingly, the threat of overpaying for chemotherapy regimens has increased. There is a need for a comprehensive review to compile relevant studies in order to inform clinician decisions on the basis of cost-effectiveness and quality of life. Objectives: The objective of this project is to assess the cost-effectiveness of anticancer medications with a special focus on the quality of life of patients undergoing chemotherapy, with the intent to form recommendations that unite evidence-based literature with clinical practice. The long-term goal is to create a clinical reference for prescribers to use in order to make more informed decisions on chemotherapy regimens. Methodology: In line with the objectives above, eligibility criteria were established to refine the database results. An initial literature search will be conducted to verify the appropriateness of the eligibility criteria and search terms. Upon finalizing study selection parameters, abstracts will be reviewed and full-text articles will be retrieved. Grey literature will be searched to eliminate publication bias. Hand searchers will be performed to ensure all studies in relevant journals will be retrieved. Selected articles will be reviewed and rated based on a modified GRADE approach. Analysis: Studies will be given a preference status based on their GRADE score. Final recommendations will be made at the professional judgments of the researchers based on pharmacoeconomic data extracted from studies weighted by preference status

A Systematic Review of the Cost-Effectiveness of Chemotherapy Regimens

Background The rising cost of chemotherapy dramatically increases the burden on healthcare and presents new challenges in achieving optimal patient outcomes. New treatments, in general, are more specialized but show minor progress in regards to efficacy. Accordingly, the threat of overpaying for chemotherapy regimens has increased. There is a need for a comprehensive review to compile relevant studies in order to inform clinician decisions on the basis of cost-effectiveness and quality of life. Objectives Therefore, the aim of this project is to assess the cost-effectiveness of anticancer medications with a special focus on the quality of life of patients undergoing chemotherapy, with the intent to form recommendations that unite evidence-based literature with clinical practice. The long term goal is to create a clinical reference for prescribers to use in order to make more informed decisions on chemotherapy regimens. Methodology In line with the objectives above, eligibility criteria was established to refine the database results. An initial literature search will be conducted to verify appropriateness of the eligibility criteria and search terms. Upon finalizing study selection parameters, abstracts will be reviewed and full text articles will be retrieved. Grey literature will be searched to eliminate publication bias. Hand searchers will be performed to ensure all studies in relevant journals will be retrieved. Selected articles will be reviewed and rated based on a modified GRADE approach. Studies will be synthesized based on GRADE score and pharmacoeconomic analysis. Analysis ­­ Studies will be given a preference status based on their GRADE score and pharmacoeconomic analysis. Final recommendations will be made at the professional judgements of the researchers based on pharmacoeconomic data extracted from studies weighted by preference status

Phonon Emission from a 2D Electron Gas: Evidence of Transition to the Hydrodynamic Regime

Using as a thermometer the temperature dependent magneto-transport of a two-dimensional electron gas, we find that effective temperature scales with current as $T_{\rm e} \sim I^a$, where $a=0.4 \pm 2\%$ in the {\it Shubnikov de-Haas} regime, and $0.53 \pm 2\%$ in both the {\it integer and fractional} quantum Hall effect. This implies the phonon energy emission rate changes from the expected $P\sim T^5$ to $P\sim T^4$. We explain this, as well as the dramatic enhancement in phonon emission efficiency using a hydrodynamic model.Comment: 4 pages, 2 Postscript figures uuencoded with TeX file uses psfig macro. Submitted to Phys. Rev. Let

Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote

The box jellyfish Chironex fleckeri is extremely venomous, and envenoming causes tissue necrosis, extreme pain and death within minutes after severe exposure. Despite rapid and potent venom action, basic mechanistic insight is lacking. Here we perform molecular dissection of a jellyfish venom-induced cell death pathway by screening for host components required for venom exposure-induced cell death using genome-scale lenti-CRISPR mutagenesis. We identify the peripheral membrane protein ATP2B1, a calcium transporting ATPase, as one host factor required for venom cytotoxicity. Targeting ATP2B1 prevents venom action and confers long lasting protection. Informatics analysis of host genes required for venom cytotoxicity reveal pathways not previously implicated in cell death. We also discover a venom antidote that functions up to 15 minutes after exposure and suppresses tissue necrosis and pain in mice. These results highlight the power of whole genome CRISPR screening to investigate venom mechanisms of action and to rapidly identify new medicines

A selected ion flow tube study of the ion-molecule reactions of monochloroethene, trichloroethene and tetrachloroethene

Data for the rate coefficients and product cations of the reactions of a large number of atomic and small molecular cations with monochloroethene, trichloroethene and tetrachloroethene in a selected ion flow tube at 298 K are reported. The recombination energy of the ions range from 6.27 eV (H$_3$O$^+$) through to 21.56 eV (Ne$^+$). Collisional rate coefficients are calculated by modified average dipole orientation theory and compared with experimental values. Thermochemistry and mass balance predict the most feasible neutral products. Together with previously reported results for the three isomers of dichloroethene (J. Phys. Chem. A., 2006, 110, 5760), the fragment ion branching ratios have been compared with those from threshold photoelectron photoion coincidence spectroscopy over the photon energy range 9-22 eV to determine the importance or otherwise of long-range charge transfer. For ions with recombination energy in excess of the ionisation energy of the chloroethene, charge transfer is energetically allowed. The similarity of the branching ratios from the two experiments suggest that long-range charge transfer is dominant. For ions with recombination energy less than the ionisation energy, charge transfer is not allowed; chemical reaction can only occur following formation of an ion-molecule complex, where steric effects are more significant. The products that are now formed and their percentage yield is a complex interplay between the number and position of the chlorine atoms with respect to the C=C bond, where inductive and conjugation effects can be important

Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol

BACKGROUND AND PURPOSE: Glycine receptors are important players in pain perception and movement disorders, and therefore an important therapeutic target. Glycine receptors can be modulated by the intravenous anesthetic propofol (2,6-diisopropylphenol); however, the drug is more potent, by at least one order of magnitude, on GABAA receptors. It has been proposed that halogenation of the propofol molecule generates compounds with selective enhancement of glycinergic modulatory properties. EXPERIMENTAL APPROACH: We synthesized 4-bromopropofol, 4-chloropropofol, and 4-fluoropropofol. The direct activating and modulatory effects of these drugs and propofol were compared on recombinant rat glycine and human GABAA receptors expressed in oocytes. Behavioral effects of the compounds were compared in the tadpole loss-of-righting assay. KEY RESULTS: The concentration-response curves for potentiation of homomeric α1, α2, and α3 glycine receptors were shifted to lower drug concentrations by 2-10-fold for the halogenated compounds. Direct activation by all compounds was minimal with all subtypes of the glycine receptor. The four compounds were essentially equally potent modulators of the α1β3γ2L GABAA receptor with EC50 s between 4 and 7 μM. The EC50 s for loss-of-righting in Xenopus tadpoles, a proxy for loss of consciousness and considered to be mediated by actions on GABAA receptors, ranged from 0.35 to 0.87 μM. Conclusions and Implications We confirm that halogenation of propofol more strongly affects modulation of homomeric glycine receptors than α1β3γ2L GABAA receptors. However, the effective concentrations of all tested halogenated compounds remained lower for GABAA receptors. We infer that 4-bromo-, 4-chloro, or 4-fluoropropofol are not selective homomeric glycine receptor modulators