Effect of yogic practices on selected physiological variables among hypertensive middle-aged women

The purpose of the random group experimental study was to investigate the effect of Yogic Practices on selected Physiological variables such as Systolic, Diastolic and Body Mass Index (BMI) among Hypertensive middle aged women. It was hypothesized that there would be a significant difference due to Yogic Practices on selected Physiological variables such as Systolic, Diastolic and Body Mass Index (BMI) among Hypertensive middle-aged women than the control group. Random group experimental design was used. The random sampling design was followed to select the subjects. To achieve the purpose of the study, 30 women between the age 45 and 55 years were selected randomly from Chennai and they were divided into two groups such as Yogic Practices (Group A) and Control Group (Group B). Each group consists of 15 subjects. The pre-test was taken for the two Groups on the selected dependent variables before the start of the training program. Group A was undergoing Yogic Practices for 12weeks, 6 days a week, One-hour maximum daily and Group B (Control Group) was permitted to undergo their normal lifestyle (active rest) during the course of the experiment. After the experimental period of 12 weeks, Post-tests were conducted for the two groups on selected dependent variables. The selected Physiological variables such as Systolic, Diastolic and Body Mass Index (BMI) were measured through Lab test. Analysis of Co-Variance (ANCOVA) was used to find out the significant difference between experimental group and the Control Group. The test of significance was fixed at 0.05 level of confidence. It was concluded that Yogic Practices improved Physiological variables among Hypertensive middle-aged women than the Control Group. Hence, the hypothesis was accepted at 0.05 level of confidence

Emerging horizons in anaesthetic practice: a pharmacological update

Anesthesiologists are in search for new drugs possessing properties like rapid onset of action, minimal residual effects, better hemodynamic stability, organ independent metabolism and cost effective. Structural alterations of the currently available compounds or newer formulations of the older ones or newer anaesthetic drug delivery system will be an useful alternative to newer discovery by reducing the cost and time. Tapentadol is a centrally acting µ opioid receptor (MOR) agonist with selective norepinephrine reuptake inhibition, approved by US FDA for treating moderate to severe acute pain in adults more than 18 years of age. Sugammadex, a novel selective relaxant binding agent to reverse steroidal neuromuscular blockers is recently approved by the European Union. Gantacurium, a rapid and ultra short acting non depolarizing neuromuscular blocker, inactivated rapidly by the adduction of non essential amino acid cysteine to the gantacurium molecule is in clinical trials. Remimazolam is a new drug in clinical trials that has a rapid onset of action like midazolam and is metabolized by non specific tissue esterases like remifentanil and expected to have a promising future. Liposomal Bupivacaine is approved by FDA in October 2011 that uses bupivacaine in liposomal vesicles to extend the duration of analgesia upto 72 hours and reduces the opioid use in the post operative period. Methoxy carbonyl carboetomidate is in clinical trials that combines the advantages of MOC etomidate and carboetomidate. Hence anaesthesiology is marching towards a bright pathway with new soft drugs coming up making not only anaesthesiology soft but also pharmacology

PREPARATION AND CHARACTERIZATION OF CEFTRIAXONE SODIUM ENCAPSULATED CHITOSAN NANOPARTICLES

Objective: The objective of this study was to prepare ceftriaxone sodium chitosan nanoparticles (CS-NP) from different drug and polymer ratios and analyze their physicochemical characteristics.Methods: Ceftriaxone sodium loaded chitosan nanoparticles were prepared using chitosan as a polymer and tri sodium polyphosphate (TPP) as cross linking agent by ionic cross linking and coacervation with the aid of sonication. Various trials have been carried out for the confirmation of nanoformulation. Parameters such as the zeta potential, polydispersity, particle size, entrapment efficiency, in vitro drug release Thermo gravimetric analysis and scanning electron microscope of the nanoparticles were assessed for confirmation of nanoformulation.Results: The formulated nanoparticles showed mean particle size, polydispersity index and zeta potential to be 183.1±8.42 nm, 0.212±0.05, +38.5±1.6 mV respectively and the drug loading was found to be 46.42±10 %. In vitro drug release was showed a biphasic release pattern with initial burst release followed by sustained release of formulated nanoparticles. The cumulative percentage of drug release was about 83.08 %.Conclusion: Formulation F2 was found to be the best formulation with a higher cumulative percentage of drug release. Modified ionic gelation method can be utilized for the development of chitosan nanoparticles of ceftriaxone sodium. Polymer and crosslinking agent concentrations and sonication time are rate-limiting factors for the development of the optimized formulation. The chitosan nanoparticles developed would be capable of sustained delivery of ceftriaxone sodium

EFFICACY OF CHONDROITIN SULFATE WITH GLUCOSAMINE VERSUS DIACEREIN IN GRADE II AND III OSTEOARTHRITIS KNEE: A RANDOMIZED COMPARATIVE STUDY

ABSTRACTObjective: Osteoarthritis (OA), the most common joint disease has led to great morbidity and disability. Symptomatic slow acting drugs for OA, whichincludes glucosamine sulfate, chondroitin sulfate, and diacerein provides symptom relief and structure-modifying effects in OA knee. Our aim was toassess the efficacy and safety of chondroitin sulfate with glucosamine versus diacerein in Kellgren-Lawrence Grade II and III OA knee patients.Methods: After approval from Institutional Human Ethics Committee and after getting written informed consent patients were randomized toGroup A: Tablet chondroitin sulfate (400 mg) with glucosamine (500 mg) combination thrice a day or Group B: Capsule diacerein 50 mg, twice aday orally both after food. Out of 88 patients screened, 75 of them entered the study. A total of 15 patients failed to complete the study. Remaining60 patients completed with 30 patients in each group. They were assessed for pain using visual analogue scale (VAS) from baseline and followed-upat 3, 12, 24 weeks.Results: Baseline characteristics in both the groups were matching without any significant difference. At 24 weeks there was reduction in VAS from6.76 to 1.96 (71.01%) in Group A and from 6.8 to 3.53 (48.09%) in Group B. There was significant difference between the groups with Group Asignificant over Group B in VAS. Thus, the effect of drug in Group A on pain reduction was greater than Group B.Conclusion: The use of chondroitin sulfate with glucosamine combination resulted in improvement in VAS better than diacerein in OA knee.Keywords: Osteoarthritis, Chondroitin sulfate with glucosamine combination, Diacerein, Visual analogue scale

Irrational prescribing: myths and facts

According to WHO, irrational prescribing is a disease which is difficult to treat but prevention is possible. There are many factors which contributes for this irrational prescribing like patient factors, practitioners/doctor factors, influence from pharmaceutical industry or combination of all

Study of Variations in the Origin and the Colic Branches of the Superior Mesenteric Artery

INTRODUCTION : Superior mesenteric artery shows variation in its origin and its branching pattern. A sound knowledge of the presence of variations of Superior mesenteric artery is important for Surgeon, Physician, Radiologist, Gastroenterologist and Vascular Surgeon. AIM OF STUDY : Examining the pattern of variations in the origin of the Superior mesenteric artery and its colic branches, mainly in South Indian population. Comparing the variations with the previous study. PARAMETER : • Level of origin, • Course of artery, • Level of termination, • In branching pattern, • Relation with coeliac trunk, • Relation with pancreas. MATERIALS AND METHODS : A total number of fifty Superior mesenteric arteries were studied. Thirty Superior mesenteric arteries were studied from the cadavers by dissection method at Government Stanley Medical College. Twenty Superior mesenteric arteries pictures of CT angiogram was taken at Department of Radiology, Government Stanley Medical College. RESULTS : The following findings were seen in the present study. • Normal origin of Superior mesenteric artery from abdominal aorta. • Superior mesenteric artery and coeliac trunk arose as a common trunk from the abdominal aorta. • Superior mesenteric artery and Inferior pancreatico duodenal artery had a common origin from the abdominal aorta. • Absence of middle colic artery. • Common origin of Right colic artery arising from the ileocolic artery. • Ileocolic and right colic artery had a common trunk from Superior mesenteric artery. • Appendicular artery arising from inferior division of ileocolic artery. • Double appendicular arteries,one from ileocolic artery before division and the other from the inferior division of ileocolic artery. CONCLUSION : A thorough knowledge about the normal pattern and abnormal pattern of Superior mesenteric artery and its branches are helpful for correct interpretation of any invasive procedures and resection of colon for carcinoma, intestine transfers, resection of small and large intestines and appendicectomy and embolectomy

Evaluation of opioid sparing effect of dexmedetomidine and pregabalin using acute pain model in male wistar rats

Background: Adjuvant analgesics are added to pain management regimen to reduce opioid consumption and minimise their side effect. Newer ones like dexmedetomidine and pregabalin have not been thoroughly researched. Objectives of the study to study the opioid sparing effect of dexmedetomidine and pregabalin using tail flick and hot plate method in male wistar rats.Methods: Forty two rats were grouped into seven groups with six in each group. Analgesic activity was tested using tail flick, where in the reaction time to flick its tail on a heated surface was noted. In the hot plate method, the reaction time to withdraw or lick the paws when placed on heated surface was noted.Results: The reaction time to flick its tail was prolonged with dexmedetomidine and pregabalin when combined with opioids even in sub therapeutic doses.Conclusion: Adjuncts like dexmedetomidine and pregabalin can be very useful  in mutimodal pain management and also to reduce the opioid consumption

Hepatoprotective and antioxidant activity of Murraya Koenigii leaves extract against paracetamol induced hepatotoxicity in Rats

Background: Many pharmacological substances are known to cause hepatic injuries and paracetamol is one out of them. This study was carried out to investigate the hepatoprotective and antioxidant activity of hydroalcoholic extract of Murraya koenigii leaves in paracetamol induced hepatotoxicity in Rats.Methods: Experimental animal used in this study were 30 healthy male albino Wistar rats of 10 to 12 wks weighing 180 ± 20 g. After acclimatization for a period of one week, the rats were randomized into five groups of six rats each. Safety profile and dose selection of extract was evaluated using acute toxicity studies. Five groups named as Normal control, Paracetamol induced hepatotoxicity, Murraya koenigii leaves extract 100 mg/kg bw, Murraya koenigii leaves extract 200 mg/kg bw and Silymarin group respectively. The doses of drugs and plant extract was calculated based on the body weight of each animal and administered orally for 7 days. On 8th day rats were sacrificed and blood samples were collected by cardiac puncture for biochemical estimation of biochemical parameters. Then abdomen was opened to get liver sample for antioxidant activity and histopathology.Results: Acute toxicity studies showed the non-toxic nature of Murraya koenigii leaves extract upto dose of 2000 mg/kg body weight. Murraya koenigii leaves extract in both doses showed a significant drop in the mean levels of AST, ALT, ALP, TP and TB when compared with toxic control group. The higher dose was found better than lower dose. Silymarin was found better than both the doses. Murraya koenigii leaves extract in both doses significantly reduced the TBARS level when compared to toxic control group. The activities of GSH, SOD and CAT in liver were significantly lower in Paracetamol induced hepatotoxicity rats compared to control rats. Murraya koenigii leaves extract at both doses showed a significant increase in GSH, SOD and CAT. The higher dose was found better than lower dose. Silymarin was found better than both the doses. Histopathology of Liver biopsy with higher dose of Murraya koenigii leaves extract showed reduced periportal inflammation with mild hepatic venous congestion and Silymarin treated rats showed no periportal inflammation with mild congestion in few central veins.Conclusions: Murraya koenigii leaves extract possesses significant Hepatoprotective property; this may be due to antioxidant activity. Further studies are required to determine the exact mechanism

N′-(2-Methyl-3-phenyl­allyl­idene)nicotinohydrazide monohydrate

The asymmetric unit of the title compound, C16H15N3O·H2O, contains an N′-(2-methyl-3-phenyl­allyl­idene)nicotino­hydra­zide mol­ecule and a water solvent mol­ecule. The dihedral angle between the pyridine ring and the phenyl ring is 47.26 (5)°. Inter­molecular O—H⋯N, O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds are found in the crystal structure. Furthermore, C—H⋯π inter­actions involving the pyridine and phenyl rings are also found

2,5-Diphenyl­penta-2,4-dienenitrile

In the title compound, C17H13N, the dihedral angle between the two phenyl rings is 17.6 (1)°. An inter­molecular C—H⋯N hydrogen bond is found in the crystal structure, also a C—H⋯π inter­action involving the phenyl ring at position 5