EFFICACY AND SAFETY EVALUATION OF SESA OIL AND SESA CAPSULE IN DIFFERENT HAIR DISORDERS

Background: Hair loss can cause psychological stress to the patient. It may be prevented if early treatment is started. A holistic approach to stop hair fall would include not only therapeutic intervention but also an active search for associated nutritional deficits. Aim: Purpose of this study was to evaluate the safety and efficacy of SESA oil and capsule in different hair disorders. Materials and Methods: A prospective cohort study was conducted at Dr. D. Y. Patil College of Ayurved and Research Institute. Totally 40 individuals, (12 women and 28 men) with alopecia were enrolled. All the patients were advised to use SESA oil and SESA capsule as directed. Results: The efficacy was assessed on every monthly follow-up for 3 months. Patients showed a marked decrease in hair fall and increase in regeneration of hair. They also showed improvement in psychological condition and secondary parameters of hair disorders. There were no adverse reactions documented, neither reported nor observed, during the entire study period. Conclusion: Therefore, it may be concluded that SESA oil and capsule are clinically effective and safe therapeutic regimens for the treatment of different hair disorders

Control of single-wall-nanotube field-effect transistors via indirect long-range optically induced processes

We observe significant changes in the response of single-wall-carbon-nanotube-based field-effect transistors upon photoexcitation in the presence of optically active conjugated polymer network. The primary features observed are in the form of an increase in the current in the depletion mode upon photoexcitation. Pulsed measurements indicate that the transistor enters the depleted state prior to the rise in current brought about by the transfer of the photogenerated carriers from the semiconducting polymer to the nanotube under depletion bias

Jyotismati Taila and Ashtamangal Ghrita Nasya in the management of Mental Retardation - A Comparative Study

Mental retardation is still elusive to researchers due to multidimensionality of psychological, medical, educational and social aspects, which alters mental functions and capability. Mental sub capability divided in 4 categories, Mild, Moderate, Severe and Profound. Chief aim of management of mental retardation is to make child more capable of performing common activities of everyday life by positive improvement in mental sub-capability. Mental retardation required multidimensional management approach. Present study focused on medicinal intervention, particularly analysis of comparative effectiveness of selected drug formulations (Astamangalghrita and Jyotismatitaila) from classical text of Ayurveda. Study design with the aims to compare the effectiveness of Jyotismatitaila and Astamangal Ghrita Nasya on Mental retardation. Assessment were based on Mental Status Score and IQ score taken before starting of treatment and after completion of treatment in both group. Obtained data was analyzed statistically. In this study, from result we conclude that both drugs are effective to improve Mental Status parameter and in IQ, but higher percentage and significance wise Jyotismati Taila had better result than Astamangal Ghrita Nasya

Histoplasmosis in an immunocompetent host: a rare case report

Histoplasmosis, a systemic mycosis caused by Histoplasma capsulatum manifests clinically in immunocompromised patients as acute or chronic pulmonary infection or as a progressive disseminated disease. In immunocompetent hosts, the disease is usually self-limited or presents as flu-like symptoms. It is endemic in North, Central and South America as well as parts of Europe and Africa. We report a case of a 76-year-old diabetic, HIV negative patient who presented with white nodular patches on the tongue and gingiva which were reported as histoplasmosis on histopathology. He also had idiopathic CD4 lymphocytopenia and thrombocytopenia

Non-autonomous stochastic evolution equations and applications to stochastic partial differential equations

In this paper we study the following non-autonomous stochastic evolution equation on a UMD Banach space $E$ with type 2, {equation}\label{eq:SEab}\tag{SE} {{aligned} dU(t) & = (A(t)U(t) + F(t,U(t))) dt + B(t,U(t)) dW_H(t), \quad t\in [0,T], U(0) & = u_0. {aligned}. {equation} Here $(A(t))_{t\in [0,T]}$ are unbounded operators with domains $(D(A(t)))_{t\in [0,T]}$ which may be time dependent. We assume that $(A(t))_{t\in [0,T]}$ satisfies the conditions of Acquistapace and Terreni. The functions $F$ and $B$ are nonlinear functions defined on certain interpolation spaces and $u_0\in E$ is the initial value. $W_H$ is a cylindrical Brownian motion on a separable Hilbert space $H$. Under Lipschitz and linear growth conditions we show that there exists a unique mild solution of \eqref{eq:SEab}. Under assumptions on the interpolation spaces we extend the factorization method of Da Prato, Kwapie\'n, and Zabczyk, to obtain space-time regularity results for the solution $U$ of \eqref{eq:SEab}. For Hilbert spaces $E$ we obtain a maximal regularity result. The results improve several previous results from the literature. The theory is applied to a second order stochastic partial differential equation which has been studied by Sanz-Sol\'e and Vuillermot. This leads to several improvements of their result.Comment: Accepted for publication in Journal of Evolution Equation

Rural Indian tribal communities: an emerging high-risk group for HIV/AIDS

BACKGROUND: Rural Indian tribes are anthropologically distinct with unique cultures, traditions and practices. Over the years, displacement and rapid acculturation of this population has led to dramatic changes in their socio-cultural and value systems. Due to a poor health infrastructure, high levels of poverty and ignorance, these communities are highly vulnerable to various health problems, especially, communicable diseases including HIV/AIDS. Our study sought to assess knowledge, attitudes and practices regarding sexuality, and the risk factors associated with the spread of HIV/AIDS and STDs among these communities. METHODS: A nested cross sectional study was undertaken as part of the on going Reproductive and Child Health Survey. A total of 5,690 participants age 18–44 were recruited for this study. Data were obtained through home interviews, and focused on socio-demographics, knowledge, attitudes and behaviors regarding sexuality, HIV/AIDS and other STDs. RESULTS: The study revealed that only 22% of adults had even heard of AIDS, and 18 % knew how it is transmitted. In addition, only 5% knew that STDs and AIDS were related to each other. AIDS awareness among women was lower compared to men (14% vs.30 %). Regarding sexual practices, 35% of the respondents reported having had extramarital sexual encounters, with more males than females reporting extramarital affairs. CONCLUSION: Lack of awareness, permissiveness of tribal societies for premarital or extra-marital sexual relationships, and sexual mixing patterns predispose these communities to HIV/AIDS and STD infections. There is a dire need for targeted interventions in order to curtail the increasing threat of HIV and other STDs among these vulnerable populations

CD137 promotes proliferation and survival of human B cells

CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown. We found that CD137 is expressed in vitro on anti-Ig–stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-g and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-a and -b. Our study suggests that CD137 costimulation may play a role in defining the fate of Agstimulated human B cells.Fil: Zhang, Xiaoyu. University of Maryland; Estados UnidosFil: Voskens, Caroline J.. University of Maryland; Estados UnidosFil: Sallin, Michelle. University of Maryland; Estados UnidosFil: Maniar, Amudhan. University of Maryland; Estados UnidosFil: Montes, Carolina Lucia. University of Maryland; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Zhang, Yue. University of Maryland; Estados UnidosFil: Lin, Wei. University of Maryland; Estados UnidosFil: Li, Guoyan. University of Maryland; Estados UnidosFil: Burch, Erin. University of Maryland; Estados UnidosFil: Tan, Ming. University of Maryland; Estados UnidosFil: Hertzano, Ronna. University of Maryland; Estados UnidosFil: Chapoval, Andrei I.. University of Maryland; Estados UnidosFil: Tamada, Koji. University of Maryland; Estados UnidosFil: Gastman, Brian R.. University of Maryland; Estados UnidosFil: Schulze, Dan H.. University of Maryland; Estados UnidosFil: Strome, Scott E.. University of Maryland; Estados Unido