135 research outputs found
Anchorage onto deciduous teeth: effectiveness of early rapid maxillary expansion in increasing dental arch dimension and improving anterior crowding
EFFECT OF PELVIC POSITIONING AND TORSIONAL DEFORMITY ON CANINE ACETABULAR MORPHOLOGY WITH COMPUTED TOMOGRAPHY: A PHANTOM STUDY
--
Ultrasound-guided removal of soft tissue foreign bodies in companion animals: A case series
Foreign bodies (FBs) retained in the subcutaneous tissues are a common reason for medical consultation.
In small animals, FBs usually consist of vegetal materials, especially grass awns. Failure to remove the FBs is likely
to give rise to acute or late complications. The surgical removal of the FBs can be invasive, costly and technically
challenging. Ultrasound has become a mainstay in the detection of FBs and it can be used to guide the extraction
of the FBs with a minimally invasive technique. This study describes the detection and extraction of soft-tissue
FBs in small animals. One hundred-sixty-two patients, presenting at two veterinary clinics with suspected FBs
retained in the soft tissues of various body districts, were considered. Once an ultrasound diagnosis was established,
the ultrasound-guided removal of the FB was performed. A high-frequency linear transducer, a skin disinfection,
sedation or anaesthesia was used when needed and a scalpel and some Hartmann forceps were also used. One
hundred-eighty-two FBs were successfully removed in all the patients. In six cases, the FB was identified during
a second ultrasonographic examination, after recurrence of the fistula. No complications were reported after
the procedure. The extraction of the FB was performed in an echographic suite in 138 cases and in a surgery room
with surgical intervention in 24 cases. In the latter situation, the surgical minimally invasive dissection of tissues
under ultrasound guidance was performed before the removal of the FB. In conclusion, the ultrasound-guided
removal of the FBs retained in the superficial soft tissue can be considered a good alternative to surgery. However,
failure to remove a FB does not preclude the removal by traditional surgery
Infancy researchers need to change the way they develop their measures: A comment on Byers‐Heinlein et al. (2021)
Radiotherapy in the COVID-19 Pandemic Era
Background/Aim: In 2020, because of coronavirus pandemic, medical activities changed. The aim of this report is to compare the volumes of Pisa radiotherapy activities from March 9th to May 31st, 2020, with the same period in 2019.
Patients and Methods: We analyzed the activity of our Unit to evaluate how logistics changes, related to the COVID-19
epidemic, impacted on volumes of radiotherapy (RT) activity and on the number of cases of COVID-19 infections observed in
healthcare professionals and patients.
Results: The total number of first-time visits between March-May 2020 was reduced by 18%, probably due to delays in diagnosis and histological tests as well as the temporary closure of the operating rooms. None of the healthcare professionals and only two patients contracted
the infection.
Conclusion: We were able to treat all patients referred to our hospital and we were able to reduce risk of infection for both our patients and healthcare staff, guaranteeing continuum of care for our oncological patien
Comparison between minimally-invasive partial and radical nephrectomy for the treatment of clinical T2 renal masses: results of a 10-year study in a tertiary care center
Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction
Background: Phosphorylation of diacylglycerol by diacylglycerol-kinases represents a major inhibitory event constraining T cell activation upon antigen engagement. Efficient TCR signalling requires the inhibition of the alpha isoform of diacylglycerol kinase, DGKα, by an unidentified signalling pathway triggered by the protein adaptor SAP. We previously demonstrated that, in SAP absence, excessive DGKα activity makes the T cells resistant to restimulation-induced cell death (RICD), an apoptotic program counteracting excessive T cell clonal expansion. Results: Herein, we report that the Wiskott-Aldrich syndrome protein (WASp) inhibits DGKα through a specific interaction of the DGKα recoverin homology domain with the WH1 domain of WASp. Indeed, WASp is necessary and sufficient for DGKα inhibition, and this WASp function is independent of ARP2/3 activity. The adaptor protein NCK-1 and the small G protein CDC42 connect WASp-mediated DGKα inhibition to SAP and the TCR signalosome. In primary human T cells, this new signalling pathway is necessary for a full response in terms of IL-2 production, while minimally affecting TCR signalling and restimulation-induced cell death. Conversely, in T cells made resistant to RICD by SAP silencing, the enhanced DAG signalling due to DGKα inhibition is sufficient to restore apoptosis sensitivity. Conclusion: We discover a novel signalling pathway where, upon strong TCR activation, the complex between WASp and DGKα blocks DGKα activity, allowing a full cytokine response
Acercando el CAPS N°44 a lxs vecinxs de Villa Progreso : Unidad Sanitaria N°44, Villa Progreso, Berisso
Este trabajo intentará dar cuenta del proceso de formación desarrollado durante el transcurso del cuatrimestre en el curso de Formación Interprofesional de la Salud, creado desde la secretaría de salud de la UNLP, donde se propone, a partir de una mirada interdisciplinar e interprofesional, construir una intervención que pueda visibilizar los abordajes de las problemáticas en salud de manera integral, en relación a la población y las problemáticas planteada desde los efectores de salud .
El objetivo fundamental del curso de formación interprofesional en salud, es generar una instancia que contribuya a la interacción entre estudiantes y actores sociales de diferentes disciplinas -Ciencias Médicas, Ciencias Exactas, Psicología, Trabajo Social, Ciencias Veterinarias-, y ámbitos del campo de la salud comunitaria. Entendiendo que el curso promueve el interprofesionalismo que nos permite analizar, reflexionar y actuar desde una perspectiva humanizadora ante los complejos procesos de salud y enfermedad que están presente en la región en la que está inserta la Universidad de La Plata.
Siendo las problemáticas de salud las que nos convocan a trabajar desde este curso, los propósitos y las acciones que integran su desarrollo nos permitirán consolidar el compromiso para con la comunidad que atraviesa problemas complejos que requieren de una mirada integral donde la dimensión de los Derechos Humanos está presente.Trabajo final del Curso de Formación Interprofesional en Salud (FIP) (UNLP)Universidad Nacional de La Plat
Machine-Learning-Based Tool to Predict Target Prostate Biopsy Outcomes: An Internal Validation Study
Abstract: The aim of this study is to present a personalized predictive model (PPM) with a machine learning (ML) system that is able to identify and classify patients with suspected prostate cancer (PCa) following mpMRI. We extracted all the patients who underwent fusion biopsy (FB) from March 2014 to December 2019, while patients from August 2020 to April 2021 were included as a validation set. The proposed system was based on the following four ML methods: a fuzzy inference system (FIS), the support vector machine (SVM), k-nearest neighbors (KNN), and self-organizing maps (SOMs). Then, a system based on fuzzy logic (FL) + SVM was compared with logistic regression (LR) and standard diagnostic tools. A total of 1448 patients were included in the training set, while 181 patients were included in the validation set. The area under the curve (AUC) of the proposed FIS + SVM model was comparable with the LR model but outperformed the other diagnostic tools. The FIS + SVM model demonstrated the best performance, in terms of negative predictive value (NPV), on the training set (78.5%); moreover, it outperformed the LR in terms of specificity (92.1% vs. 83%). Considering the validation set, our model outperformed the other methods in terms of NPV (60.7%), sensitivity (90.8%), and accuracy (69.1%). In conclusion, we successfully developed and validated a PPM tool using the FIS + SVM model to calculate the probability of PCa prior to a prostate FB, avoiding useless ones in 15% of the cases
Changes in immunohistochemical levels and subcellular localization after therapy and correlation and colocalization with CD68 suggest a pathogenetic role of Hsp60 in ulcerative colitis.
In an earlier work, the role of heat shock protein
(Hsp60) in the pathogenesis of ulcerative colitis (UC) was
suggested by its significant increase in the pathological mucosa
parallel with an increase in inflammatory cells. More data in this
direction are reported in this work. We analyzed by immunohistochemistry
biopsies of colon tissue from 2 groups of patients with
UC and treated with either 5-aminosalicylic acid (5-ASA) alone or
in combination with a probiotic. We looked for inflammatory
markers and Hsp60. Both the treatments were effective in reducing
symptoms but the group treated with both 5-ASA and probiotics
showed better clinical results. Amelioration of symptoms was
associated with reduction of both inflammation and Hsp60, a
reduction that was most marked in the group treated with 5-ASA
and probiotics. The levels of Hsp60 positively correlated with
those of CD68-positive cells, and double immunofluorescence
showed a high index of colocalization of the chaperonin and CD68
in lamina propria. Immunoelectron microscopy showed thatHsp60Fclassically a mitochondrial proteinFwas abundantly
also present in cytosol in biopsies taken at the time of diagnosis,
but not after the treatment. Our data suggest that Hsp60 is an
active player in pathogenesis of UC and it can be hypothesized
that the chaperonin is responsible, at least in part, for initiation
and maintenance of disease
- …