36 research outputs found
Quality evaluation of Zanthoxylum rhetsa fruits and seeds - a Thai traditional medicine
335-340Zanthoxylum rhetsa (Roxb.) DC or Ma-khwuang (Rutaceae family) has long been used in Thai culinary and traditional medicine. Its fruits and seeds are used for anti-diabetic, antispasmodic, diuretic and anti-inflammatory activity. Based on its medicinal usage, we have evaluated the quality parameters of Z. rhetsa fruits and seeds. Ten samples of Z. rhetsa fruits and seeds from different topographical areas, throughout Thailand, were examined following WHO guideline for quality control of medicinal plant materials. The Z. rhetsa fruits and seeds were evaluated by microscopic and physicochemical studies. The GC-MS study showed the major phytoconstituents of Z. rhetsa are sabinene (56.62%), 4-terpineol (13.82%), germacrene (10.1%), gramma-terpinene (5.5%) and alpha-terpinene (3.5%). These pharmacognostic specifications with GC-MS can be used to develop some standard parameters for judge the quality, quantity and impurity of Z. rhetsa crude drug future
Indizoline1
The title compound [systematic name: 1-methoxy-2-(3-methylbut-2-enyl)-9H-carbazole-3-carbaldehyde], C19H19NO2, is a natural carbazole which was isolated from the twigs of Clausena lansium. The carbazole ring system is essentially planar with a mean deviation of 0.0068 (10) Å. The aldehyde substituent is approximately co-planar with the attached benzene ring with a torsion angle of −8.58 (14)°, whereas the methoxy group is rotated out of the benzene plane with a torsion angle of −82.17 (11)°. The dihedral angle between the mean planes of the 3-methyl-2-butenyl group and the carbazole ring is 88.06 (5)°. An intermolecular N—H⋯O interaction connects the molecules into a chain along the a axis. The crystal is further consolidated by a C—H⋯O hydrogen bond and two π–π interactions with centroid–centroid distances of 3.6592 (6) and 3.7440 (6) Å
Quality evaluation of Zanthoxylum rhetsa fruits and seeds - a Thai traditional medicine
Zanthoxylum rhetsa (Roxb.) DC or Ma-khwuang (Rutaceae family) has long been used in Thai culinary and traditional medicine. Its fruits and seeds are used for anti-diabetic, antispasmodic, diuretic and anti-inflammatory activity. Based on its medicinal usage, we have evaluated the quality parameters of Z. rhetsa fruits and seeds. Ten samples of Z. rhetsa fruits and seeds from different topographical areas, throughout Thailand, were examined following WHO guideline for quality control of medicinal plant materials. The Z. rhetsa fruits and seeds were evaluated by microscopic and physicochemical studies. The GC-MS study showed the major phytoconstituents of Z. rhetsa are sabinene (56.62%), 4-terpineol (13.82%), germacrene (10.1%), gramma-terpinene (5.5%) and alpha-terpinene (3.5%). These pharmacognostic specifications with GC-MS can be used to develop some standard parameters for judge the quality, quantity and impurity of Z. rhetsa crude drug future
Glycozolidal
The title compound known as glycozolidal (systematic name: 2,7-dimethoxy-9H-carbazole-3-carbaldehyde), C15H13NO3, is a naturally occurring carbazole, which was isolated from the roots of Clausena lansium. The carbazole ring system is essentially planar, with an r.m.s. deviation of 0.0093 (1) Å. In the crystal, intermolecular N—H⋯O hydrogen bonds connect the molecules into a chain along the c axis. C—H⋯O, C—H⋯π and π–π interactions, with centroid–centroid distances of 3.5924 (6), 3.6576 (6) and 3.8613 (6) Å, are also observed
2-Hydroxy-7-methoxy-9H-carbazole-3-carbaldehyde
The title compound, C14H11NO3, was isolated from the roots of Clausena wallichii. The carbazole ring system is approximately planar (r.m.s. deviation = 0.039 Å) and the dihedral angle between the two benzene rings is 4.63 (7)°. An intramolecular O—H⋯O hydrogen bond generates an S(6) ring motif. In the crystal, molecules are linked into a zigzag network extending parallel to the ac plane by O—H⋯N and N—H⋯O hydrogen bonds
12-hydroxycorniculatolide A from the mangrove tree, Lumnitzera littorea
A new macrocyclic lactone, 12-hydroxycorniculatolide A (1), along with three known compounds, corniculatolide A (2), 12-hydroxy-11-O-methylcorniculatolide A (3) and 6,7-dimethoxycoumarin (4) were isolated from the methanolic extract of the twigs of Lumnitzera littorea. All compounds were characterized using spectroscopic methods. All compounds were screened against a panel of six Gram positive and five Gram negative bacteria
A tocotrienol quinone dimer and xanthones from the leaf extract of Garcinia nigrolineata
Four new compounds (1-4) together with six known compounds (5-10) were isolated from the leaf extract of Garcinia nigrolineata. Compound 4 is a rare tocotrienol quinone dimer. The structures were elucidated based on NMR and MS data. All isolated compounds were evaluated for their antibacterial activities
Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa
The first phytochemical investigation of the stem extract of Millettia extensa resulted in the isolation and identification of six new isoflavones, millexatins A-F (1-6), together with 16 known compounds. The structures of these new compounds were determined on the basis of their spectroscopic data. Millexatin A (1) is a rare isoflavone containing three isoprenyl units on a modified A ring. Compounds 1, 6, 10, 11, and 14 displayed promising antibacterial activity with MIC values of 2-8 μg/mL