2,531 research outputs found
GeoCLEF 2006: the CLEF 2006 Ccross-language geographic information retrieval track overview
After being a pilot track in 2005, GeoCLEF advanced to be a regular track within CLEF 2006. The
purpose of GeoCLEF is to test and evaluate cross-language geographic information retrieval (GIR): retrieval for
topics with a geographic specification. For GeoCLEF 2006, twenty-five search topics were defined by the
organizing groups for searching English, German, Portuguese and Spanish document collections. Topics were
translated into English, German, Portuguese, Spanish and Japanese. Several topics in 2006 were significantly
more geographically challenging than in 2005. Seventeen groups submitted 149 runs (up from eleven groups and
117 runs in GeoCLEF 2005). The groups used a variety of approaches, including geographic bounding boxes,
named entity extraction and external knowledge bases (geographic thesauri and ontologies and gazetteers)
Challenges to evaluation of multilingual geographic information retrieval in GeoCLEF
This is the third year of the evaluation of
geographic information retrieval (GeoCLEF)
within the Cross-Language Evaluation Forum
(CLEF). GeoCLEF 2006 presented topics and
documents in four languages (English,
German, Portuguese and Spanish). After two
years of evaluation we are beginning to
understand the challenges to both Geographic
Information Retrieval from text and of
evaluation of the results of geographic
information retrieval. This poster enumerates
some of these challenges to evaluation and
comments on the limitations encountered in the
first two evaluations
Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma
: Neuroblastoma is the most common extra-cranial solid tumour in children. Despite multi-modal therapy, over half of the high-risk patients will succumb. One contributing factor is the one-size-fits-all nature of multi-modal therapy. For example, during the first step (induction chemotherapy), the standard regimen (rapid COJEC) administers fixed doses of chemotherapeutic agents in eight two-week cycles. Perhaps because of differences in resistance, this standard regimen results in highly heterogeneous outcomes in different tumours. In this study, we formulated a mathematical model comprising ordinary differential equations. The equations describe the clonal evolution within a neuroblastoma tumour being treated with vincristine and cyclophosphamide, which are used in the rapid COJEC regimen, including genetically conferred and phenotypic drug resistance. The equations also describe the agents' pharmacokinetics. We devised an optimisation algorithm to find the best chemotherapy schedules for tumours with different pre-treatment clonal compositions. The optimised chemotherapy schedules exploit the cytotoxic difference between the two drugs and intra-tumoural clonal competition to shrink the tumours as much as possible during induction chemotherapy and before surgical removal. They indicate that induction chemotherapy can be improved by finding and using personalised schedules. More broadly, we propose that the overall multi-modal therapy can be enhanced by employing targeted therapies against the mutations and oncogenic pathways enriched and activated by the chemotherapeutic agents. To translate the proposed personalised multi-modal therapy into clinical use, patient-specific model calibration and treatment optimisation are necessary. This entails a decision support system informed by emerging medical technologies such as multi-region sequencing and liquid biopsies. The results and tools presented in this paper could be the foundation of this decision support system
A Hebbian approach to complex network generation
Through a redefinition of patterns in an Hopfield-like model, we introduce
and develop an approach to model discrete systems made up of many, interacting
components with inner degrees of freedom. Our approach clarifies the intrinsic
connection between the kind of interactions among components and the emergent
topology describing the system itself; also, it allows to effectively address
the statistical mechanics on the resulting networks. Indeed, a wide class of
analytically treatable, weighted random graphs with a tunable level of
correlation can be recovered and controlled. We especially focus on the case of
imitative couplings among components endowed with similar patterns (i.e.
attributes), which, as we show, naturally and without any a-priori assumption,
gives rise to small-world effects. We also solve the thermodynamics (at a
replica symmetric level) by extending the double stochastic stability
technique: free energy, self consistency relations and fluctuation analysis for
a picture of criticality are obtained
Design of an electron microscope phase plate using a focused continuous-wave laser
We propose a Zernike phase contrast electron microscope that uses an intense
laser focus to convert a phase image into a visible image. We present the
relativistic quantum theory of the phase shift caused by the
laser-electron-interaction, study resonant cavities for enhancing the laser
intensity, and discuss applications in biology, soft materials science, and
atomic and molecular physics.Comment: 5 pages, 3 figure
Predictors and outcomes of crossover to surgery from physical therapy for meniscal tear and osteoarthritis a randomized trial comparing physical therapy and surgery
BACKGROUND: Arthroscopic partial meniscectomy (APM) combined with physical therapy (PT) have yielded pain relief similar to that provided by PT alone in randomized trials of subjects with a degenerative meniscal tear. However, many patients randomized to PT received APM before assessment of the primary outcome. We sought to identify factors associated with crossing over to APM and to compare pain relief between patients who had crossed over to APM and those who had been randomized to APM. METHODS: We used data from the MeTeOR (Meniscal Tear in Osteoarthritis Research) Trial of APM with PT versus PT alone in subjects ≥45 years old who had mild-to-moderate osteoarthritis and a degenerative meniscal tear. We assessed independent predictors of crossover to APM among those randomized to PT. We also compared pain relief at 6 months among those randomized to PT who crossed over to APM, those who did not cross over, and those originally randomized to APM. RESULTS: One hundred and sixty-four subjects were randomized to and received APM and 177 were randomized to PT, of whom 48 (27%) crossed over to receive APM in the first 140 days after randomization. In multivariate analyses, factors associated with a higher likelihood of crossing over to APM among those who had originally been randomized to PT included a baseline Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Score of ≥40 (risk ratio [RR] = 1.99; 95% confidence interval [CI] = 1.00, 3.93) and symptom duration of <1 year (RR = 1.74; 95% CI = 0.98, 3.08). Eighty-one percent of subjects who crossed over to APM and 82% of those randomized to APM had an improvement of ≥10 points in their pain score at 6 months, as did 73% of those who were randomized to and received only PT. CONCLUSIONS: Subjects who crossed over to APM had presented with a shorter symptom duration and greater baseline pain than those who did not cross over from PT. Subjects who crossed over had rates of surgical success similar to those of the patients who had been randomized to surgery. Our findings also suggest that an initial course of rigorous PT prior to APM may not compromise surgical outcome. LEVEL OF EVIDENCE: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence
Generating functional for the gravitational field: implementation of an evolutionary quantum dynamics
We provide a generating functional for the gravitational field, associated to
the relaxation of the primary constraints as extended to the quantum sector.
This requirement of the theory, relies on the assumption that a suitable time
variable exist, when taking the T-products of the dynamical variables. More
precisely, we start from the gravitational field equations written in the
Hamiltonian formalism and expressed via Misner-like variables; hence we
construct the equation to which the T-products of the dynamical variables obey
and transform this paradigm in terms of the generating functional, as taken on
the theory phase-space. We show how the relaxation of the primary constraints
(which correspond to break down the invariance of the quantum theory under the
4-diffeomorphisms) is summarized by a free functional taken on the Lagrangian
multipliers, accounting for such constraints in the classical theory. The issue
of our analysis is equivalent to a Gupta-Bleuler approach on the quantum
implementation of all the gravitational constraints; in fact, in the limit of
small , the quantum dynamics is described by a Schr\"odinger equation,
as soon as the mean values of the momenta, associated to the lapse function and
the shift vector, are not vanishing. Finally we show how, in the classical
limit, the evolutionary quantum gravity reduces to General Relativity in the
presence of an Eckart fluid, which corresponds to the classical counterpart of
the physical clock, introduced in the quantum theory.Comment: 23 pages, no figures, to appear on International Journal of Modern
Physics
Complement component 4A protein levels are negatively related to frontal volumes in patients with schizophrenia spectrum disorders
Background: Excessive C4A-gene expression may result in increased microglia-mediated synaptic pruning. As C4A overexpression is observed in schizophrenia spectrum disorders (SSD), this mechanism may account for the altered brain morphology (i.e. reduced volume and cortical thickness) and cognitive symptoms that characterize SSD. Therefore, this study investigates the association of C4A serum protein levels with brain morphology and cognition, and in particular whether this association differs between recent-onset SSD (n = 69) and HC (n = 40). Methods: Serum C4A protein levels were compared between groups. Main outcomes included total gray matter volume, mean cortical thickness and cognitive performance. Regression analysis on these outcomes included C4A level, group (SSD vs. HC), and C4A*Group interactions. All statistical tests were corrected for age, sex, BMI, and antipsychotic medication dose. Follow-up analyses were performed on separate brain regions and scores on cognitive sub-tasks. Results: The group difference in C4A levels was not statistically significant (p = 0.86). The main outcomes did not show a significant interaction effect (p > 0.13) or a C4A main effect (p > 0.27). Follow-up analyses revealed significant interaction effects for the left medial orbitofrontal and left frontal pole volumes (p < 0.001): C4A was negatively related to these volumes in SSD, but positively in HC. Conclusion: This study demonstrated that C4A was negatively related to – specifically – frontal brain volumes in SSD, but this relation was inverse for HC. The results support the hypothesis of complement-mediated brain volume reduction in SSD. The results also suggest that C4A has a differential association with brain morphology in SSD compared to HC.</p
Covariant and locally Lorentz-invariant varying speed of light theories
We propose definitions for covariance and local Lorentz invariance applicable
when the speed of light is allowed to vary. They have the merit of
retaining only those aspects of the usual definitions which are invariant under
unit transformations, and which can therefore legitimately represent the
outcome of an experiment. We then discuss some possibilities for invariant
actions governing the dynamics of such theories. We consider first the
classical action for matter fields and the effects of a changing upon
quantization. We discover a peculiar form of quantum particle creation due to a
varying . We then study actions governing the dynamics of gravitation and
the speed of light. We find the free, empty-space, no-gravity solution, to be
interpreted as the counterpart of Minkowksi space-time, and highlight its
similarities with Fock-Lorentz space-time. We also find flat-space string-type
solutions, in which near the string core is much higher. We label them
fast-tracks and compare them with gravitational wormholes. We finally discuss
general features of cosmological and black hole solutions, and digress on the
meaning of singularities in these theories.Comment: To be published in Physical Review
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