ESTUDO DE CASO: PROGRAMA VOLTA AO TRABALHO COM SEGURANÇA - O DIREITO À SAÚDE NO AMBIENTE DE TRABALHO DURANTE O ENFRENTAMENTO À PANDEMIA DA COVID-19

A pandemia causada pelo vírus COVID-19 mudou a vida de toda a população mundial a partir dos hábitos e relacionamentos sociais até as questões econômicas por exemplo. Tudo isso causou mudanças muito profundas nos indivíduos, causando um sentimento de cuidar mais de si e do coletivo. A saúde nunca foi tão priorizada como agora, por isso este estudo teve o objetivo de analisar o modo com que a saúde em meio a pandemia vem sendo abordada dentro das empresas. A empresa em que o estudo foi realizado, é especialista em segurança e saúde no trabalho (SST), ela foi responsável pela elaboração de um plano de contingência visando medidas de prevenção de infecção individual e coletiva. Cinco empresas que implantaram o programa foram avaliadas, e pode-se perceber que as mesmas já adotavam as medidas de prevenção básicas, mas ainda necessitavam de melhorias, estas que foram todas elencadas pela empresa de SST. Sendo possível observar, portanto, que o plano de contingência serve como guia para assegurar a saúde dentro do ambiente de trabalho além de garantir a não propagação do vírus para fora da empresa. Palavras-chave: COVID-19. Plano de contingência. Saúde

ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia

Abstract Extracellular signal-regulated kinase-1/2 (ERK1/2) is frequently found constitutively activated (p-ERK1/2) in hematopoietic diseases, suggesting a role in leukemogenesis. The aim of this study was to assess the expression and clinical role of p-ERK1/2 in adult acute lymphoblastic leukemia (ALL). In 131 primary samples from adult de novo ALL patients enrolled in the Gruppo Italiano per le Malattie Ematologiche dell'Adulto (GIMEMA) Leucemia Acute Linfoide (LAL) 2000 protocol and evaluated by flow cytometry, constitutive ERK1/2 activation was found in 34.5% of cases; these results were significantly associated with higher white blood cell (WBC) values (P = .013). In a multivariate analysis, p-ERK1/2 expression was an independent predictor of complete remission achievement (P = .027). Effective approaches toward MEK inhibition need to be explored in order to evaluate whether this may represent a new therapeutic strategy for adult ALL patients

Antidiabetic Drug Prescription Pattern in Hospitalized Older Patients with Diabetes

Objective: To describe the prescription pattern of antidiabetic and cardiovascular drugs in a cohort of hospitalized older patients with diabetes. Methods: Patients with diabetes aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro POliterapuie SIMI—Società Italiana di Medicina Interna) registry from 2010 to 2019 and discharged alive were included. Results: Among 1703 patients with diabetes, 1433 (84.2%) were on treatment with at least one antidiabetic drug at hospital admission, mainly prescribed as monotherapy with insulin (28.3%) or metformin (19.2%). The proportion of treated patients decreased at discharge (N = 1309, 76.9%), with a significant reduction over time. Among those prescribed, the proportion of those with insulin alone increased over time (p = 0.0066), while the proportion of those prescribed sulfonylureas decreased (p < 0.0001). Among patients receiving antidiabetic therapy at discharge, 1063 (81.2%) were also prescribed cardiovascular drugs, mainly with an antihypertensive drug alone or in combination (N = 777, 73.1%). Conclusion: The management of older patients with diabetes in a hospital setting is often sub-optimal, as shown by the increasing trend in insulin at discharge, even if an overall improvement has been highlighted by the prevalent decrease in sulfonylureas prescription