Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1 alpha, (PGC-1alpha), peroxisome proliferator-activated receptor gamma (PPARgamma) and estrogen related receptor alpha (ERRalpha)

International audienceIn patients with sepsis, liver metabolism and its capacity to provide other organs with energeticsubstrates are impaired. This and many other pathophysiological changes seen in human patients arereproduced in mice injected with purified endotoxin (lipopolysaccharide, LPS). In the present study,down-regulation of genes involved in hepatic fatty acid oxidation (FAOx) and gluconeogenesis in miceexposed to LPS was challenged by nutritional intervention with argan oil. Mice given a standard chowsupplemented or not with either 6% (w/w) argan oil (AO) or 6% (w/w) olive oil (OO) prior toexposure to LPS were explored for liver gene expressions and enzyme activities. LPS-treated micewere protected by nutritional AO or OO supplementations against down-regulations of hepatic FAOxand gluconeogenesis. Underlying mechanisms lied in a prevention of sepsis-associated drops in hepaticexpressions of nuclear receptors PPARα and ERRα and coactivator PGC-1α. These preventive mechanisms conveyed by AO against LPS-induced metabolic dysregulation might add new therapeuticpotentialities in the management of human sepsis