Nuclear medicine practice in Japan: a report of the seventh nationwide survey in 2012

Objective The Subcommittee on the Survey of Nuclear Medical Practice in Japan has performed a nationwide survey of nuclear medicine practice every 5 years since 1982 to survey contemporary nuclear medicine practice and its changes over the years. Methods The subcommittee sent questionnaires, including the number and category of examinations as well as the kind and dose of the radiopharmaceuticals during the 30 days of June 2012, to all the nuclear medicine institutes. The total numbers for the year 2012 were then estimated. Results A total of 1,167 institutes responded to the survey, including the 14 in vitro assay institutes and 266 PET centers. The recovery rate was 92 %. The number of gamma cameras installed was 1,425 in total, with 9 % decrease in 5 years. Dual-head cameras and hybrid SPECT/CT scanners accounted for 84 and 10.5 %, respectively. The number of single-photon tracer studies in 2012 was 1.15 million which means decrease in 19 % in 5 years and 29 % in 10 years. All but cerebral perfusion study and sentinel lymphoscintigraphy have decreased. Bone scintigraphy was a leading examination (38.7 %), followed by cardiac studies (29.4 %) and cerebral perfusion study (18.5 %) in order. SPECT studies showed an increase from 42.3 to 47.2 %. PET centers have also increased from 212 to 295, as compared to the last survey. The 135 PET centers have installed one or two in-house cyclotrons. PET studies showed 25.5 % increase in 5 years, with oncology accounting for 96.3 %. 18F-FDG accounted for 98.2 % (505,990 examinations). PET examinations using 11C-methionine have been increasing, with 3,352 examinations in 2012. The number of new PET studies using 11C-PIB PET was 695. 131I-radioiodine targeted therapies showed an increase, including 3,644 patients (53.6 %) for thyroid cancer and 4,889 patients (17.9 %) for hyperthyroidism. Out-patient thyroid bed ablation therapy with 30 mCi of 131I accounted for 21.0 % of cancer patients. The number of admission rooms decreased from 158 to 135 in 5 years. In vitro radioassays have been declining continuously since 1992, with the number of studies of 9.0 million in 2012. Conclusions Single-photon examinations showed a continuous tendency toward a decline in the survey. In contrast, the number of hybrid SPECT/CT scanner examinations has increased. PET/CT study in the oncology field and radionuclide targeted therapy have steadily increased. © 2014 The Japanese Society of Nuclear Medicine

朗読会

写真あり大学祭朗読会の感想 : 武田真奈(英語英米文学科)大学祭朗読会 : 鈴木珠友(音楽芸術学科)神奈川近代文学館での朗読会 : 小野紘子(日本語日本文学科)神奈川近代文学館朗読会 : 匿名(日本語日本文学科

2016年度読書運動プロジェクト活動報告書

活動資料 p.(1)～p.(5)はじめに : 藤本 朝巳 p.1読書会 : 中村 好花、小根山 桃子 p.2-p.3コンテスト・コンクール : 森園 佳子 p.4-p.5展示 : 秋葉 祐子 p.6-p.9コラボランチ : 有馬 梨咲 p.10選書ツアー : 小根山 桃子 p.11文学散歩 : 中村 好花 p.12大学祭 : 秋葉 祐子、有馬 梨咲 p.13-p.15読み聞かせレッスン : 森園 佳子 p.16小学校朗読会 : 阿部 果鈴、山田 優香、穂積 優香 p.17-p.18朗読会 : 武田 真奈、鈴木 珠友、小野 紘子、匿名 p.19-p.22プロフィール p.23-p.29おわりに : 森園 佳子 p.30写真あり表あ

Synthesis of Tetrachloro, Tetraiodo, and Tetraazido Double-Decker Siloxanes

International audienceA convenient and scalable (gram-scale) route to unprecedented T 8 D 2-doubledecker siloxanes (DDSQs) bearing four chloro (3b) or four azido (5b) groups is reported. Both compounds were characterized and proved to undergo successful nucleophilic substitution for 3b (with iodide or azide) and copper-catalyzed azide−alkyne [3 + 2] cycloaddition for 5b. All of these transformations occurred under mild conditions, and the corresponding DDSQs were prepared in very high yields. Beyond the enhanced multivalency as compared to the previously described disubstituted D 2 T 8 structures, the reported tetrafunctional DDSQs are formed as a single isomer and readily isolated in very high yields. Moreover, the tetra-azido DDSQ 5b constitutes a multipurpose nanobuilding block for the further preparation of new inorganic−organic hybrid materials where the covalent incorporation of a DDSQ moiety brings valuable properties

Synthesis and characterization of tetrathiol-substituted double-decker or ladder silsesquioxane nano-cores

International audienc

Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy

PGAM5 is a unique type of protein phosphatase that exists in mitochondria. It has been shown to exist in the inner mitochondrial membrane through its transmembrane domain and to be cleaved within the transmembrane domain upon mitochondrial dysfunction. However, its submitochondrial localization remains controversial; many researchers claim that PGAM5 localizes to the outer mitochondrial membrane based on the findings that PGAM5 associates with many cytoplasmic proteins. Here, we found that cleaved PGAM5 was released from mitochondria during mitophagy, a selective form of autophagy specific for mitochondria,and that the release was inhibited by proteasome inhibitors in HeLa cells stably expressing the E3 ubiquitin ligase Parkin.However, treatment of parental HeLa cells lacking Parkin with mitophagy-inducing agents caused PGAM5 cleavage but did not cause its release from mitochondria. Thus, cleaved PGAM5 appears to be released from mitochondria depending on proteasome-mediated rupture of the outer membrane during mitophagy, which has been previously shown to precede autophagy-mediated degradation of whole mitochondria. This study suggests that PGAM5 senses mitochondrial dysfunction in the inner mitochondrial membrane and serves as a signalling intermediate that regulates the cellular response to mitochondrial stress upon its cleavage and release from mitochondria

Characterization of Polyurethane Shape Memory Polymer and Determination of Shape Fixity and Shape Recovery in Subsequent Thermomechanical Cycles

Multifunctional polyurethane shape memory polymers (PU-SMPs) have been of increasing interest in various applications. Here we report structure characterization, detailed methodology, and obtained results on the identification of functional properties of a thermoset PU-SMP (MP4510) with glass transition temperature of 45 °C. The stable, chemically crosslinked network of this thermoset PU-SMP results in excellent shape memory behavior. Moreover, the proximity of the activation temperature range of this smart polymer to room and body temperature enables the PU-SMP to be used in more critical industrial applications, namely fast-response actuators. The thermomechanical behavior of a shape memory polymer determines the engineering applications of the material. Therefore, investigation of the shape memory behavior of this class of commercial PU-SMP is of particular importance. The conducted structural characterization confirms its shape memory properties. The shape fixity and shape recovery properties were determined by a modified experimental approach, considering the polymer’s sensitivity to external conditions, i.e., the temperature and humidity variations. Three thermomechanical cycles were considered and the methodology used is described in detail. The obtained shape fixity ratio of the PU-SMP was approximately 98% and did not change significantly in the subsequent cycles of the thermomechanical loading due to the stability of chemical crosslinks in the thermoset materials structure. The shape recovery was found to be approximately 90% in the first cycle and reached a value higher than 99% in the third cycle. The results confirm the effect of the thermomechanical training on the improvement of the PU-SMP shape recovery after the first thermomechanical cycle as well as the effect of thermoset material stability on the repeatability of the shape memory parameters quantities