Conservative interventions for managing urinary incontinence after prostate surgery

Peer reviewedPublisher PD

Citološka analiza urina i popratni pregled za interpretaciju i praćenje urinarnih tumora

Microscopic appearance of cells in urine cytological samples is the formal diagnostic approach adjunct to cystoscopy for the detection and follow-up of urinary tumors. However, cystoscopy is a surgical method and cytology may miss low-grade papillary tumors. Several assays and markers have been developed to assist in this. When combined with conventional cytology, uro-oncological diagnostic performance is improved. We review the value of these non-invasive modalities in comparison with urine cytomorphology in the work-up of urothelial malignancies.Pregled stanica urinarinih citoloških uzoraka mikroskopom je formalni dijagnostički pristup koji se, uz citologiju, koristi za otkrivanje i praćenje urinarnih tumora. No citoskopija je kirurška metoda, a citologiji mogu promaknuti papilarni tumori niskog stupnja. Razvijeno je nekoliko analiza i biljega koji u tome pomažu. Kada se koriste uz konvencionalnu citologiju, poboljšava se uspješnost uro-onkološke dijagnostike. Pružamo pregled korisnosti ovih ne-invazivnih modaliteta u usporedi s urinarnom citomorfologijom u analizi malignih tumora mokraćnog mjehura

The modified Clavien classification system: a standardized platform for reporting complications in transurethral resection of the prostate

The aim of the study was to evaluate the applicability of the modified Clavien classification system (CCS) in grading perioperative complications of transurethral resection of the prostate (TURP). All patients with benign prostatic hyperplasia submitted to monopolar TURP from January 2006 to February 2008 at a non-academic center were evaluated for complications occurring up to the end of the first postoperative month. All complications were classified according to the modified CCS independently by two urologists, and the final decision was based on consensus. If multiple complications per patient occurred, categorization was done in more than one grade. Results were presented as complication rates per grade. Forty-four complications were recorded in 31 out of 198 patients (overall perioperative morbidity rate: 15.7%), and their grading was generally easy, non-time-consuming and straightforward. Most of them were classified as grade I (59.1%) and II (29.5%). Higher grade complications were scarce (grade III: 2.3% and grade IV: 6.8%, respectively) There was one death (grade V: 2.3%) due to acute myocardial infarction (overall mortality rate: 0.5%). Negative outcomes such as mild dysuria during this early postoperative period or retrograde ejaculation were considered sequelae and were not recorded. Nobody was complicated with severe dysuria. There was one re-operation due to residual adenoma (0.5%). The modified CCS represents a straightforward and easily applicable tool that may help urologists to classify the complications of TURP in a more objective and detailed way. It may serve as a standardized platform of communication among clinicians allowing for sound comparison

Conservative interventions for managing urinary incontinence after prostate surgery

Acknowledgements: We would like to thank Sheila Wallace, Lindsey Elstub, Nicole O'Connor and Claire Eastaugh for their editorial support on this review. We are grateful to the following people for assisting with translations for the review:• Gabriela Azevedo Sansoni: Faculty of Medicine and Surgery, University of Milan• Yuan Chi: Health Network, China; Cochrane Campbell Global Ageing Partnership, UK • Elaine Martí • Benjamin Hernández Wolters: Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico • Fangfang Zhao: Chinese Journal of Integrated Traditional and Western Medicine, China; Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, China Editorial and peer-reviewer contributions The following people conducted the editorial process for this article. • Sign-oH Editor (final editorial decision): Luke Vale, Cochrane's editorial board. • Managing Editor (selected peer reviewers, collated peer-reviewer comments, provided editorial guidance to authors, edited the article): Samuel Hinsley, Central Editorial Service • Editorial Assistant (conducted editorial policy checks and supported editorial team): Leticia Rodrigues, Central Editorial Service • Copy Editor (copy editing and production): Heather Maxwell • Peer-reviewers (provided comments and recommended an editorial decision): Dr. M.S. Rahnama'i st. Elisabeth - Tweesteden Hospital Tilburg - The Netherlands (clinical review), Akhil Das, MD FACS, University of California Irvine (clinical review), Brian Duncan (consumer review), Nuala Livingstone, Cochrane Evidence Production and Methods Directorate (methods review), Anne Littlewood, Cochrane Oral Health (search review). 1 of additional peer reviewers provided clinical peer review but chose not to be publicly acknowledged. Funding Information: Dr Moore's studies were funded for 4 years by a Doctoral Fellowship from the Kidney Foundation of Canada. Funding for the research project was received from the Oncology Nurses' Society, Canadian Nurses' Foundation, Caritas Health, Alberta Physiotherapy Association, Edna Minton Foundation, and the University of Edmonton, Canada This study was supported by grant R01 DK60044 from the National Institute of Diabetes and Digestive and Kidney Diseases and by the Department of Veterans Affairs Birmingham–Atlanta Geriatric Research, Education, and Clinical Center. We would like to thank the National Science Council Grant of Taiwan for financial support (NSC 96-2314-B-214-007; NSC 97-2314-B-214-009-MY2). Four studies stated that they did not receive any funding, while seven were funded solely by governmental organisations and one solely by a foundation. One study was funded by a governmental organisation and a university, one by a charity and a university and one through both charity and a pharmaceutical company. Ten studies did not report where they had obtained funding for their study. Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), 2003/07656-7. This study received financial support from the National Council for Scientific and Technological Development (CNPq) through scientific research grant to the author This study was funded by the Foundation for Research Support of the State of São Paulo (FAPESP), under registration number 2011/12154-7. This study was supported by a grant from the Fund of Scientific Research, Flanders, Belgium Funded by the Alberta Heritage Foundation for Medical Research, the Northern Alberta Urology Foundation, and Pfizer Corporation (unrestricted). Scientific Research Foundation of Zhuhai Science and Technology Industry and Trade Bureau, No.2012D0401990028 Conflicts of interest: Quote: "All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Goode reported receiving a research grant from Pfizer. Dr Bur-gio reported serving on the advisory board of Astellas, as a consultant to GlaxoSmithKline, and as receiving research grants and serving as a consultant to Pfizer. Dr Johnson reported receiving grant support from Astellas, Pfizer and Vantia and serving as a consultant for Boehringer-Ingelheim, Ferring, Johnson & Johnson, Pfizer, and Vantia. Dr Issa reported serving as a consultant for and on the speakers bureau and receiving honoraria from GlaxoSmithKline. Dr Lloyd reported receiving research support from Allergan, Indevus, and Pfizer; serving as a consultant to and on the speakers bureau of Astellas, Boehringer-Ingelheim, GlaxoSmithKline, Novartis, and Pfizer. No other authors reported having a financial conflict of interest" Publisher Copyright: Copyright © 2023 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.Peer reviewe

COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic/pandemic events and prevalence

Occupational, residential, dietary and environmental exposures to mixtures of synthetic anthropogenic chemicals after World War II have a strong relationship with the increase of chronic diseases, health cost and environmental pollution. The link between environment and immunity is particularly intriguing as it is known that chemicals and drugs can cause immunotoxicity (e.g., allergies and autoimmune diseases). In this review, we emphasize the relationship between long-term exposure to xenobiotic mixtures and immune deficiency inherent to chronic diseases and epidemics/pandemics. We also address the immunotoxicologic risk of vulnerable groups, taking into account biochemical and biophysical properties of SARS-CoV-2 and its immunopathological implications. We particularly underline the common mechanisms by which xenobiotics and SARS-CoV-2 act at the cellular and molecular level. We discuss how long-term exposure to thousand chemicals in mixtures, mostly fossil fuel derivatives, exposure toparticle matters, metals, ultraviolet (UV)–B radiation, ionizing radiation and lifestyle contribute to immunodeficiency observed in the contemporary pandemic, such as COVID-19, and thus threaten global public health, human prosperity and achievements, and global economy. Finally, we propose metrics which are needed to address the diverse health effects of anthropogenic COVID-19 crisis at present and those required to prevent similar future pandemics

What Is the Required Certainty of Evidence for the Implementation of Novel Techniques for the Treatment of Benign Prostatic Obstruction?

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Noninvasive Assessment of Exercise-Related Intramyocellular Acetylcarnitine in Euglycemia and Hyperglycemia in Patients With Type 1 Diabetes Using 1H Magnetic Resonance Spectroscopy: A randomized single-blind crossover study

Intramyocellular acetylcarnitine (IMAC) is involved in exercise-related fuel metabolism. It is not known whether levels of systemic glucose influence IMAC levels in type 1 diabetes