Morphometry of Glenoid Cavity

Objectives: Knowledge of the shape and dimensions of the glenoid are important in the design and fitting of glenoid components for total shoulder arthroplasty. An understanding of variations in normal anatomy of the glenoid is essential while evaluating pathological conditions like osseous Bankart lesions and osteochondral defects. Methods: This study was done on 202 dry, unpaired adult human scapulae of unknown sex belonging to the south Indian population. Three glenoid diameters were measured, the superior-inferior diameter, anterior-posterior diameter of the lower half and the anterior-posterior diameter of the upper half of the glenoid. Based on a notch present on the anterior glenoid rim, variations in the shape of the glenoid cavity were classified as inverted comma shaped, pear shaped and oval. Results: The average superior-inferior diameter on right and the left sides were 33.67±2.82mm and 33.92±2.87mm respectively. The average anterior-posterior diameter of the lower half of the right glenoid was 23.35±2.04mm and that of the left was 23.02±2.30mm. The mean diameter of the upper half of the right glenoid was 16.27±2.01mm and that of the left was 15.77±1.96mm. Conclusion: The dimensions of the glenoid observed in the present study were lesser than those recorded in the studies done on other populations. This fact may be taken into consideration while designing glenoid prostheses for the south Indian population. The current study recorded a higher percentage of glenoid cavities having the glenoid notch as compared to earlier studies. While evaluating defects/lesions of the glenoid, this fact could be useful

A comparative study to assess the efficacy and safety of bepotastine and cetirizine in allergic rhinitis

Background: Pharmacotherapy is the mainstay of allergic rhinitis and many caregivers use over-the-counter antihistamines. Bepotastine is a novel oral second generation non-sedative antihistamine and an effective treatment option for allergic rhinitis. The objectives of the present study were to evaluate the efficacy and safety of bepotastine versus cetirizine an over the counter drug.Methods: A prospective, randomized, open-label, parallel-group study was conducted among 60 patients fulfilling the inclusion and exclusion criteria. Group A (n=30) received tablet cetirizine 10 mg once daily and Group B (n=30) received tablet bepotastine 10 mg once daily. Efficacy was assessed by mean change in total symptom score (TSS) which is the sum of total nasal symptom score and total ocular symptom score at the end of two weeks from baseline.Results: At the end of two weeks of treatment, both groups showed statistically significant (p<0.005) improvements from their baseline TSS. Mean TSS was reduced from12.36±2.12 to 4.2±1.66 in group A and from 13.33±3.039 to 3.033±1.40 in Group B. Significant statistical difference in TSS was seen more in Group B than Group A (p<0.005).Conclusions: Both the groups showed a substantial therapeutic benefit in patients with allergic rhinitis, however bepotastine is more effective.

A CRITICAL REVIEW OF RASAOUSHADIES IN THE MANAGEMENT OF NETRA ROGAS (EYE DISEASES)

In Ayurveda chikitsa paddhati, Rasa oushadhis has been considered more useful and effective as they are more advantageous due to their unique benefits over the other preparations. Medicines described to manage different diseases in our classical texts contain different sources like plants, marine, animals, minerals and metals. All these are formulated in such a way that it suits well to our body. This clearly states that there were usage of herbomineral preparations in therapeutics which includes for Netrarogas also. These preparations are significant in many chronic and challenging eye disorders of this era which lacks curative rate and has high recurrences.To deal such challenging disorders of the Eye whether chronic or newly existing, essential to review and re-establish the importance of Rasa oushadhis which are explained by our Acharyas pertaining to Netra rogas, with regard to its route of administration and posology. For this Review work, information were compiled from different texts according to Rasadravyas mentioned as Chakshushya and to treat Netra rogas i.e., Maharasa, Uparasa, Sadharanrasa, Dhatu, Ratna, Sudha varga. Further the different Yogas of Netra Roga containing Rasadravyas as one of the ingredients is compiled as an attempt to establish Rasaushadhi - the need of the hour for Netra Rogas

Assessment of efficacy and safety of clindamycin with nicotinamide in mild to moderate acne vulgaris: a prospective study

Background: Acne vulgaris is a very common skin disease that is usually treated with topical products, systemic medications, or a combination of both. Acne vulgaris affects approximately 9% of the population worldwide causing permanent physical scarring, negatively affects the quality of life and self-image, and has been associated with increased rates of anxiety, depression, and suicidal ideation. Methods: This was a prospective study conducted at BMCRI including thirty-five subjects who were diagnosed with mild to moderate acne vulgaris. Patients were treated with topical clindamycin 1% with nicotinamide 4%. Efficacy was assessed by mean change in acne severity index (ASI) and total lesion count (TLC) from baseline and at the end of 4, 8 and 12 weeks. Safety was assessed by adverse events reported. Results: There was statistically significant improvement noted at the end of each visit. Baseline ASI was 88.05±4.02 and end of 12 weeks was 14.17±2.7. Baseline TLC was 30.17±1.33 and at the end of 12 weeks was 4.25±0.99. Both the ASI and TLC results were statistically significant at the end of fourth, eighth and twelfth-week p value &lt;0.0001. Conclusions: Combination topical formulations are the most broadly used treatment regimen for Acne vulgaris to target one or more steps in the pathogenesis of acne. From the results of the present study the participants on combination of clindamycin with nicotinamide had a significant improvement in acne lesions at end of 12th week of topical application and were satisfied with the therapy with no major adverse effects

AN INSIGHT TO RETINITIS PIGMENTOSA AND MANAGEMENT BY AYURVEDIC THERAPIES

Retinitis pigmentosa (RP) is a hereditary group of degenerative eye diseases caused by genetic mutations affecting retina that lead to severe vision loss and blindness. In Ayurveda, the conditions like Kapha vidagdha drushti, Hraswajadya and Dhoomadarshi which has night blindness as the cardinal feature can be simulated to different stages of RP. Certain authenticated therapies are explained in our ancient literature which are time tested such as Tarpana (Nourishing eye bath therapy), Putapaka (eye bath therapy), Anjana (Collyrium), Nasya (Processed liquid instillation through nostrils by drops or powders), Sirodhara (application of continuous stream of oil over the head), Vasti (Medicated enema) etc. through which considerable results are achieved. The drugs and procedures described in Ayurveda have probable mode of action in crossing the blood retinal barrier, a protective measure of cells surrounding the retina. The extent of benefit in alleviating the clinical features of RP happens possibly because of the phytonutrients present in the formulations applied through various procedures crossing the blood retinal barrier. To validate the management protocol explained in classics, a retrospective study was conducted on five patients selected from the OPD/IPD of Dept of Shalakya Tantra of Sri Kalabyraveshwaraswamy Ayurvedic Medical College, Hospital &amp; Research centre, Vijayanagar (SKAMCH &amp; RC). The results assessed statistically proved significant in certain parameters indicating a beneficial effect in reducing the subjective symptoms of Retinitis pigmentosa

DESIGNING A PVC FOR DC-COMPONENT

The electricity component is really a special issue in transformer less grid-connected solar (PV) inverter systems and could cause problems regarding system operation and safety. IEEE standard has defined the limit for electricity component within the grid-side ac power. The electricity component can cause line-frequency power ripple, electricity-link current ripple, along with a further second-order harmonic within the ac current. This paper has suggested a highly effective means to fix minimize the electricity component in three-phase ac power and created a software-based approach to imitate the obstructing capacitors employed for the electricity component minimization, the so-known as virtual capacitor. The suggested method continues to be validated on a ten-kVA experimental prototype, in which the electricity current has been effectively attenuated to become within .5% from the ranked current. The entire harmonic distortion and also the second-order harmonic have been reduced along with the electricity-link current ripple. The “virtual capacitor” is accomplished with the addition of an important from the electricity component in the present feedback path. A technique for accurate extraction ofthe electricity component according to no time at all integral, like a answer to achieve the control, continues to be devised and approved effective even under grid-frequency variation and harmonic conditions. A proportional integral-resonant controller is further made to regulate the dc and line-frequency component in the present loop to supply precise control from the electricity current

Temperature and blood flow distribution in the human leg during passive heat stress

The influence of temperature on the hemodynamic adjustments to direct passive heat stress within the leg’s major arterial and venous vessels and compartments remains unclear. Fifteen healthy young males were tested during exposure to either passive whole-body heat stress to levels approaching thermal tolerance (core temperature, Tc + 2 °C; Study 1; n=8) or single leg heat stress (Tc + 0 °C; Study 2; n=7). Whole-body heat stress increased perfusion and decreased oscillatory shear index in relation to the rise in Tleg in all three major arteries supplying the leg - plateauing in the common and superficial femoral arteries prior to reaching severe heat stress levels. Isolated leg heat stress increased arterial blood flows and shear patterns to a level similar to that obtained during moderate core hyperthermia (Tc + 1°C). Despite modest increases in great saphenous venous blood flow (0.2 l/min), the deep venous system accounted for the majority of returning flow (common femoral vein 0.7l/min) during intense to severe levels of heat stress. Rapid cooling of a single leg during severe whole-body heat stress resulted in an equivalent blood flow reduction in the major artery supplying the thigh deep tissues only - suggesting central temperature-sensitive mechanisms contribute to skin blood flow alone. These findings further our knowledge of leg hemodynamic responses during direct heat stress and provide evidence of potentially beneficial vascular alterations during isolated limb heat stress that are equivalent to those experienced during exposure to moderate levels of whole-body hyperthermia

IMPLEMENTATION OF AN AUTOMATIC LPGGAS DETECTION AND ALERT SYSTEM

Gas leakage is a major problem with industrialsector and residential premises. The safety workenvironment is important for every worker in theindustries, hotels, restaurants etc. and important tocreate a safer workplace. Gas accidents are vitalissues for all areas of life where precautions arevery important. One of the preventive methods tostop accident associated with the gas leakage is toinstall gas leakage detection kit at vulnerableplaces. The aim of this project is to present such adesign that can automatically detect, stop and alertgas leakage in vulnerable premises. Therefore animplementation of an automatic LPG gas detectionand alert system is proposed in our project. Proposed design can help us to avoid Gasleakage kind of problem in our daily life. The aimof this project is to monitor for liquid petroleum gas(LPG) leakage to avoid fire accidents providing safety feature where security has been animportant issue. The system detects the leakageofthe LPG using gas sensor and alerts the consumerabout the gas leakage by sending SMS