An Ecological Model of Academic Negative Prediction Defiance in College Students

Pathways to becoming a college student are as numbered and varied as college students themselves. For some people, the pathway to college is marked by barriers, such as negative messages received by the student regarding their abilities to attend college and/or the likelihood that they will get to attend college. On one hand, research suggests that children and adolescents internalize these negative messages, which then have the potential to block achievement in higher education. On the other hand, the general body of resilience research suggests that youth can overcome challenges and defy negative influences, as did the participants of the current study. However, little is known about this process of achievement in the face of negative predictions. Consequently, the current study used qualitative grounded theory methodology to explore the experience of defying negative messages received about becoming a college student. In unstructured interviews, fourteen undergraduate students described their experience of receiving negative messages about their abilities to attend college or the likelihood that they would get to attend college, as well as their subsequent experience of becoming college students in the face of these messages. Based on the literature regarding resilience, negative prediction defiance, and the effects of expectations on academic competence, an ecological model of overcoming negative messages was proposed in which micro, meso, and macrosystemic influences were hypothesized to play a role in encouraging or discouraging college attendance. Although participants came from diverse demographic backgrounds and experienced varied types of negative messages, all of their narratives shared major components, which comprise the theory proposed in the current study. These components are sources of negative messages, perceived underlying influences on sources, reasons to defy the message, facilitators of defiance, and barriers to defiance. This theory was compared to existing theories regarding resilience, negative prediction defiance, and the effects of expectations on academic competence. Additionally, research and policy implications are discussed that highlight the importance of providing youth who may be at-risk to receive negative messages with support in their families, schools, and communities

Separaxion anxiety in pediatric migraine without aura: A pilot study

Background: Separation anxiety (SA) can be defined as the fear reaction and protest manifested by children when the main caregivers move away from him/her or in front of unfamiliar person. SA near eight months may be considered as an important and normal phase of the correct and typical social neurodevelopment. Aims of the present pilot study is assessing the prevalence of separation anxiety in a population of patients with migraine without aura (MwA). Materials and methods: 119 children (69 males) suffering from MwA (mean age 1.78 ± 7:59) were consecutively recruited. The control population consisted of 231 (114 males) healthy subjects similar for age (7.64 ± 1:34; p = 0.768) and gender (p=0.987) The Screen for child anxiety related emotional disorders (SCARED) test was used to assess the prevalence of separation anxiety among MwA children. Results: Healthy individuals are on average less affected (mean 4.72 ± 0:32) of the Separation Anxiety Disorder respect of MwA children (mean 6.83 ± 0.97; p < 0.001) (Figure 1). Conclusion. MwA presents many psychiatric comorbidities and among ones separation anxiety may be considered in the clinical and therapeutic management of pediatric primary headache

Application of design for environment principles combined with LCA methodology on automotive product process development: The case study of a crossmember

none4noThe existing Community regulation pushes the carmakers to design eco-sustainability of the vehicle over its life cycle to limit the consequences of the current state and the expected growth of the sector. In this sense, one of the primary aim is reducing raw materials consumption and emissions through the adoption of innovative materials and technologies. This implies the need for the carmakers to integrate Design for Environment (DfE) principles at the early Research and Development (R&D) stage. The article presents a concreate example of integration of DfE and LCA methodology application in the R&D process of a vehicle component produced by Magneti Marelli. The study allowed drawing a balance between the advantages of a lightweight solution with respect to the standard one both from performance and environmental point of view.openMaltese, S.; Delogu, M.; Zanchi, L.*; Bonoli, A.Maltese, S.; Delogu, M.; Zanchi, L.*; Bonoli, A

Environmental assessment of light weighting solutions for automotive components: results, trade‐off and challenges from real case studies

In the last few decades, the automotive industry is facing the most deal with sustainability programs due to the increase of legislate limits on CO2 emissions and vehicle recyclability rate. Consequently, decisions on products design and development go together with environmental considerations, by starting to look for the employment of lighter materials, thus reducing vehicle mass weight and therefore fuel consumption and CO2 emissions during the dominant operation stage of a vehicle’s life cycle. To tackle this problem many of today automotive components are made of alternative materials like plastics, polymer composites, lighter metals which should lead to weight reduction with the same mechanical performances. Magneti Marelli® designs and produces hi-tech systems and components for the automotive sector representing a significant contribution on vehicle mass weight with a roughly 15% portion of incidence. So, in accordance to the environmental regulations, the Company has started to get involved into sustainability programs by focusing attention on the environmental impact of its products. In particular since 2012 Magneti Marelli has included in its mission the “improvement of environmental and energy performances of products and relatives processes during their whole life cycle, through innovative methodologies that assess the potential impacts in a quantitative way”, in this way highlighting the importance of meeting the increasing stakeholders’ expectations and their requests for transparency in results’ communication. This work addresses the main outcomes stemmed from the several LCA studies carried out over different components in terms of materials and technologies production allowing a wider environmental conscious related to the usage of different materials and manufacturing processes. Results showed that the materials employed offer the major contribution on the total impact especially for raw materials extraction and production and for the vehicle use phase, with a further substantial difference connected to the use of virgin instead of recycled materials. The main discussed points will be: i) the trade-off between production phase and use phase impacts; ii) End-of-Life analysis at component level beside the ISO 22628:2002 for the whole vehicle; iii) critical analysis and selection of environmental indicators significant for the automotive sector. Keywords Automotive sector, Life Cycle Assessment, vehicle component, Sustainable Manufacturing, Design for Environment, composites, light weightin

Introduction into Italy of Gryon pennsylvanicum (Ashmead), an egg parasitoid of the alien invasive bug Leptoglossus occidentalis Heidemann

Leptoglossus occidentalis (Heteroptera, Coreidae), a Nearctic species, was accidentally introduced into Northern Italy in the late 1990s, from where it has spread throughout Europe. The bug causes abortion of immature cones of Pinus pinea L., with economic impact on the pine-nut industry. As part of a pest control research program, the egg parasitoid Gryon pennsylvanicum Ashmead (Hymenoptera, Platygastridae) was collected from British Columbia, Canada, and legally introduced to a quarantine climatic chamber in Florence, Italy. The egg parasitoid will be tested against native non target heteropterans, an environmental impact assessment will be conducted, and a mass rearing method will be developed if appropriate. The ultimate goal is to release G. pennsylvanicum into Italian P. pinea forests for classical biological control of L. occidentalis

Progression of motor deficits in glioma-bearing mice: impact of CNF1 therapy at symptomatic stages

Glioblastoma (GBM) is the most aggressive type of brain tumor. In this context, animal models represent excellent tools for the early detection and longitudinal mapping of neuronal dysfunction, that are critical in the preclinical validation of new therapeutic strategies. In a mouse glioma model, we developed sensitive behavioral readouts that allow early recognizing and following neurological symptoms. We injected GL261 cells into the primary motor cortex of syngenic mice and we used a battery of behavioral tests to longitudinally monitor the dysfunction induced by tumor growth. Grip strength test revealed an early onset of functional deficit associated to the glioma growth, with a significant forelimb weakness appearing 9 days after tumor inoculation. A later deficit was observed in the rotarod and in the grid walk tasks. Using this model, we found reduced tumor growth and maintenance of behavioral functions following treatment with Cytotoxic Necrotizing Factor 1 (CNF1) at a symptomatic stage. Our data provide a detailed and precise examination of how tumor growth reverberates on the behavioral functions of glioma-bearing mice, providing normative data for the study of therapeutic strategies for glioma treatment. The reduced tumor volume and robust functional sparing observed in CNF1-treated, glioma-bearing mice strengthen the notion that CNF1 delivery is a promising strategy for glioma therapy

A Reliable and Cost-Efficient PCR-RFLP Tool for the Rapid Identification of Cetaceans in the Mediterranean Sea

Twenty-five species of cetaceans have been reported throughout the Mediterranean Sea, eight of them are commonly distributed in the whole basin and are regularly found beached or adrift in the sea. Stranded animals are frequently found in poor conservation status, preventing reliable identification; identification is thus often based solely on morphological features. Therewith, molecular tools are especially useful to provide taxonomic identification. In this work, a four-enzymes PCR-RFLP in silico protocol, based on a fragment of the mitochondrial gene cytb, has been designed for cetacean species occurring in the Mediterranean Sea. Moreover, beached or floating specimen samples belonging to the eight common species have been tested in the laboratory, providing evidence that this approach represents a reliable, cost- and time-effective tool for their specific identification

VISUOMOTOR INTEGRATION SKILLS IN CHILDREN AFFECTED BY OBSTRUCTIVE SLEEP APNEA SYNDROME: A CASE-CONTROL STUDY

Introduction: Sleep related breathing disorders (SRBD) consist of frequent and repetitive episodes of pharyngeal obstruction during sleep, with consequent intermittent hypoxia, sleep architecture fragmentation, daytime sleepiness and/or behavioural problems and executive impairment in children. When untreated, SRBD and obstructive sleep apnea syndrome (OSA) mainly, may impact school performance, cognition, metabolism, and cardiovascular function. Aim of the present study is assessing the visuomotor integration skills in children affected by OSA. Materials and methods: 57 subjects affected by mild-to severe OSA, PSG diagnosed according to international diagnostic criteria, (31 males and 26 females) (mean age 10.8; SD \ub1 2.49) and 83 healthy children (45 males and 38 females) (mean age 9.95; SD \ub1 1.87; p = 0.725). All subjects underwent assessment of motor coordination skills with Movement-ABC tests and visual-motor integration ability with Visual Motor Integration (VMI) test. Results: The subjects with OSA show a worse average performances in all items of Movement ABC (p <0.001) respect of controls. Specifically, children with OSAS show significantly higher values of total points (p <0.001), manual dexterity (p <0.001), ball skills (p <0.001) and balance (p <0.001). Accordingly, the average centile in OSA children at the MABC-test is significantly reduced compared with controls (p <0.001). (Table 1) On the other hand, the VMI test evaluation among children with OSAS shows worst result in total Visuo-Motor Integration (p <0.001), and in Motor Coordination sub-item (p <0.001) than controls. (Table 1). Conclusion: Our results also support for children and adolescents the hypothesis that executive functioning deficits might be linked primarily to the degree of severity nocturnal hypoxemia rather than daytime sleepiness, although several other studies are needed

Microenvironment in neuroblastoma: Isolation and characterization of tumor-derived mesenchymal stromal cells

Background: It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas (NB-MSCs) to define interactions with the tumor microenvironment. Methods: Specimens were obtained from 7 pediatric patients diagnosed with neuroblastoma (NB). Morphology, immunophenotype, differentiation capacity, proliferative growth, expression of stemness and neural differentiation markers were evaluated. Moreover, the ability of cells to modulate the immune response, i.e. inhibition of phytohemagglutinin (PHA) activated peripheral blood mononuclear cells (PBMCs) and natural killer (NK) cytotoxic function, was examined. Gene expression profiles, known to be related to tumor cell stemness, Wnt pathway activation, epithelial-mesenchymal transition (EMT) and tumor metastasis were also evaluated. Healthy donor bone marrow-derived MSCs (BM-MSC) were employed as controls. Results: NB-MSCs presented the typical MSC morphology and phenotype. They showed a proliferative capacity superimposable to BM-MSCs. Stemness marker expression (Sox2, Nanog, Oct3/4) was comparable to BM-MSCs. NB-MSC in vitro osteogenic and chondrogenic differentiation was similar to BM-MSCs, but NB-MSCs lacked adipogenic differentiation capacity. NB-MSCs reached senescence phases at a median passage of P7 (range, P5-P13). NB-MSCs exhibited greater immunosuppressive capacity on activated T lymphocytes at a 1:2 (MSC: PBMC) ratio compared with BM-MSCs (p = 0.018). NK cytotoxic activity was not influenced by co-culture, either with BM-MSCs or NB-MSCs. Flow-cytometry cell cycle analysis showed that NB-MSCs had an increased number of cells in the G0-G1 phase compared to BM-MSCs. Transcriptomic profiling results indicated that NB-MSCs were enriched with EMT genes compared to BM-MSCs. Conclusions: We characterized the biological features, the immunomodulatory capacity and the gene expression profile of NB-MSCs. The NB-MSC gene expression profile and their functional properties suggest a potential role in promoting tumor escape, invasiveness and metastatic traits of NB cancer cells. A better understanding of the complex mechanisms underlying the interactions between NB cells and NB-derived MSCs should shed new light on potential novel therapeutic approaches

Thermal and Economic Efficiency of Progressive Retrofit Strategies for School Buildings by a Statistical Analysis based Tool

Design alternatives in air conditioned buildings may be easily compared just by summing the hourly consumption of primary energy, while quantitative approachs for bioclimatic design strategies are difficult to be assessed and compared. A actively heated and passively cooled school building is considered as an application field of a novel methodology to promote an informed choice about the retrofit strategies to be adopted for buildings, defined as the Gained Comfort Cost (GCC). A functional and significant unit (i.e. a classroom), is used to test different energy retrofit solutions and their performances were compared with a baseline, in terms of the capacity to reduce the indoor air temperature variation. The novel methodology is a visual tool allowing to understand the “distance” of indoor conditions from comfort; the retrofit strategies are promoted to reduce this distance considering however the associated costs (LCC) to deal with actual feasibility