Muon-spin-rotation study of the magnetic structure in the tetragonal antiferromagnetic state of weakly underdoped Ba1−x _{1-x} Kx _{x} Fe2 _{2} As2 _{2}

With muon spin rotation ($\mu$SR) we studied the transition between the orthorhombic antiferromagnetic (o-AF) and the tetragonal antiferromagnetic (t-AF) states of a weakly underdoped Ba$_{1-x}$K$_{x}$Fe$_{2}$As$_{2}$ single crystal. We observed some characteristic changes of the magnitude and the orientation of the magnetic field at the muon site which, due to the fairly high point symmetry of the latter, allow us to identify the magnetic structure of the t-AF state. It is the so-called, inhomogeneous double-$\mathbf{Q}$ magnetic structure with $c$-axis oriented moments which has a vanishing magnetic moment on half of the Fe sites.Comment: 5 pages, 4 figures. Supplementary Material: 8 figure

Specialized Detention and Correctional Facilities

The placements covered in this chapter include child and youth residential treatment facilities, juvenile detention and correctional facilities, juvenile sexual offender treatment facilities, women\u27s prisons, and military detention and correctional institutions. For each of these specialized placements, we present their history and current philosophy,outline basic components of design, treatment services, and programming: and review the satus of evidence-based practice

Specialized Detention and Correctional Facilities

The placements covered in this chapter include child and youth residential treatment facilities, juvenile detention and correctional facilities, juvenile sexual offender treatment facilities, women\u27s prisons, and military detention and correctional institutions. For each of these specialized placements, we present their history and current philosophy,outline basic components of design, treatment services, and programming: and review the satus of evidence-based practice

Diagnoses of uncertain significance: kidney genetics in the 21st century

The increasing availability of sequencing has accelerated the discovery of genetic causes of kidney disease, with clear benefits for patients. However, insufficient or contradictory evidence exists for numerous variants that were previously reported to be pathogenic, calling into question some proposed gene–disease associations. Rigorous re-appraisal of evidence is needed to ensure diagnostic accuracy

A radiating dyon solution

We give a non-static exact solution of the Einstein-Maxwell equations (with null fluid), which is a non-static magnetic charge generalization to the Bonnor-Vaidya solution and describes the gravitational and electromagnetic fields of a nonrotating massive radiating dyon. In addition, using the energy-momentum pseudotensors of Einstein and Landau and Lifshitz we obtain the energy, momentum, and power output of the radiating dyon and find that both prescriptions give the same result.Comment: 9 pages, LaTe

Test evaluation trials present different challenges for trial managers compared to Intervention trials

Introduction Test evaluation trials present different challenges for trial managers compared to intervention trials. There has been very little research on the management of test evaluation trials and how this impacts on trial success, in comparison with intervention trials. Evaluations of medical tests present specific challenges, because they are a pivot point bridging the complexities of pathways prompting testing with treatment decision-making. We systematically explored key differences in the trial design and management of test evaluation trials compared to intervention trials at the different stages of study design and delivery. We identified challenges in test evaluation trials that were more pronounced than in intervention trials, based on experience from 10 test evaluation trials. Methods We formed a focus group of 7 trial managers and a statistician who had been involved in the day-to-day management of both test evaluation trials and intervention trials. We used discussion and content analysis to group challenges from 10 trials into a structured thematic format. The trials covered a range of medical conditions, diagnostic tests, clinical pathways and conditions including chronic kidney disease, chronic pelvic pain, colitis, detrusor over-activity, group B streptococcal colonisation, tuberculosis and colorectal, lung, ovarian and thyroid cancers. Results We identified 10 common themes underlying challenges that are more pronounced in test evaluation compared to intervention trials. We illustrate these themes with examples from 10 trials, including with 31 specific challenges we experienced. The themes were ethics/governance; accessing patient populations; recruitment; patient preference; test processes, clinical pathways and samples storage; uncertainty of diagnostic results; verifying diagnosis (reference standard); follow-up; adverse effects; and diagnostic impact. Conclusion We present 10 common themes, including 31 challenges, in test evaluation trials that will be helpful to others designing and managing future test evaluation trials. Proactive identification of potential challenges at the design and planning stages of test evaluation trials will enable strategies to improve trial design and management that may be different from standard strategies used for intervention trials. Future work could extend this topic to include challenges for other trial stakeholders including participants, clinicians, statisticians and funders

Eosinophil-derived neurotoxin and clinical outcomes with mepolizumab in severe eosinophilic asthma

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