Synthesis and antimicrobial activity of pyrimidine aalts with chloranilic and picric acids

Pyrimidine salts such as 2-methyl-5-nitro-phenyl-(4-pyridin-3-yl-pyrimidin-2-yl)-amine (1) and 4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-yl-amino)-phenyl-amine (2) with chloranilic and picric acids were synthesized, and their in vitro antibacterial and antifungal activities were evaluated. The synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, and H-1 NMR spectral studies. Compounds 2a exhibited good inhibition towards antimicrobial activity compared to the other compounds

Studies on synthesis of pyrimidine derivatives and their antimicrobial activity

A series of novel 2-(5-bromo-2-chloro-pyrimidin-4-ylsulfanyl)-4-methoxy-phenylamine derivatives were synthesized by the reaction of 2-(5-bromo-2-chloro-pyrimidin-4-ylsulfanyl)-4-methoxy-phenylamine with various sulfonyl chlorides, and their in vitro antimicrobial activity was evaluated. The synthesized compounds were characterized by elemental analyses, FT-IR, 1H NMR and LC–MS spectral studies

An efficient synthesis of tert-butyl ethers/esters of alcohols/amino acids using methyl tert-butyl ether

A facile synthesis of a wide variety of tert-butyl ethers and tert-butyl ester derivatives under mild conditions is described. Alcohols etherified with tert-butyl methyl ether as tert-butyl source and solvent, in the presence of sulfuric acid. Many amino acid tert-butyl esters have been synthesized by this procedure. The reaction is simple, inexpensive, easily scaled up, and proceeds without observable racemization. A green method was developed for the deprotection of this group using Amberlite resin IR 120-H as catalyst

A green method for selective acetylation of primary alcohols using ethyl acetate and solid potassium carbonate

A simple and selective acetylation of primary alcohols in the presence of other reactive functionalities such as secondary alcohol, phenol, acetonide and amine is described using mild ethyl acetate as the acetyl-transfer agent and solid potassium carbonate as the catalyst

Photoreduction of benzophenone analogues by alcohol and ether: Self recognition molecular assemblies

Photoreduction of benzophenone analogues 1 to benzopinacol analogues 2 in 2-propanol and diethyl ether have been studied under various experimental conditions. Two analogues namely 1,2-ethanediol 1,2-bis (3,4-dimethoxyphenyl)-1,2-diphenyl 2a and 1,2-ethanediol, 1,2-bis (l,4-benzodioxin)-1,2 diphenyl 2b have been isolated and structurally characterized by X-ray crystallography. The structures of 2a and 2b indicate that these two are programmed molecular systems with complementary recognition groups that contain information for the self assembly into supramolecular ribbons

Photoreduction of benzophenone analogues by alcohol and ether: Self recognition molecular assemblies

196-200Photoreduction of benzophenone analogues 1 to benzopinacol analogues 2 in 2-propanol and diethyl ether have been studied under various experimental conditions. Two analogues namely 1,2-ethanediol 1,2-bis (3,4-dimethoxyphenyl)-1,2-diphenyl 2a and 1,2-ethanediol, 1,2-bis (l,4-benzodioxin)-1,2 diphenyl 2b have been isolated and structurally characterized by X-ray crystallography. The structures of 2a and 2b indicate that these two are programmed molecular systems with complementary recognition groups that contain information for the self assembly into supramolecular ribbons