New method for critical failure prediction of complex systems

Rigorous analytical technique, called criticality determination methodology /or CD technique/ determines the probability that a given complex system will successfully achieve stated objectives. The CD technique identifies critical elements of the system by a failure mode and effects analysis

A Concise Introduction to Perturbation Theory in Cosmology

We give a concise, self-contained introduction to perturbation theory in cosmology at linear and second order, striking a balance between mathematical rigour and usability. In particular we discuss gauge issues and the active and passive approach to calculating gauge transformations. We also construct gauge-invariant variables, including the second order tensor perturbation on uniform curvature hypersurfaces.Comment: revtex4, 16 pages, 3 figures; v2: minor changes, typos corrected, reference added, version accepted by CQ

Detection of a Moving Rigid Solid in a Perfect Fluid

In this paper, we consider a moving rigid solid immersed in a potential fluid. The fluid-solid system fills the whole two dimensional space and the fluid is assumed to be at rest at infinity. Our aim is to study the inverse problem, initially introduced in [3], that consists in recovering the position and the velocity of the solid assuming that the potential function is known at a given time. We show that this problem is in general ill-posed by providing counterexamples for which the same potential corresponds to different positions and velocities of a same solid. However, it is also possible to find solids having a specific shape, like ellipses for instance, for which the problem of detection admits a unique solution. Using complex analysis, we prove that the well-posedness of the inverse problem is equivalent to the solvability of an infinite set of nonlinear equations. This result allows us to show that when the solid enjoys some symmetry properties, it can be partially detected. Besides, for any solid, the velocity can always be recovered when both the potential function and the position are supposed to be known. Finally, we prove that by performing continuous measurements of the fluid potential over a time interval, we can always track the position of the solid.Comment: 19 pages, 14 figure

Free Abelian 2-Form Gauge Theory: BRST Approach

We discuss various symmetry properties of the Lagrangian density of a four (3 + 1)-dimensional (4D) free Abelian 2-form gauge theory within the framework of Becchi-Rouet-Stora-Tyutin (BRST) formalism. The present free Abelian gauge theory is endowed with a Curci-Ferrari type condition which happens to be a key signature of the 4D non-Abelian 1-form gauge theory. In fact, it is due to the above condition that the nilpotent BRST and anti-BRST symmetries of the theory are found to be absolutely anticommuting in nature. For our present 2-form gauge theory, we discuss the BRST, anti-BRST, ghost and discrete symmetry properties of the Lagrangian densities and derive the corresponding conserved charges. The algebraic structure, obeyed by the above conserved charges, is deduced and the constraint analysis is performed with the help of the physicality criteria where the conserved and nilpotent (anti-)BRST charges play completely independent roles. These physicality conditions lead to the derivation of the above Curci-Ferrari type restriction, within the framework of BRST formalism, from the constraint analysis.Comment: LaTeX file, 21 pages, journal referenc

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor

Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation. Although the majority of patients initially respond favourably to androgen deprivation therapy, the mean time to relapse is 12-18 months. Currently there are few treatments available for men who have developed resistance to hormone therapy, due to the lack of understanding of the molecular mechanisms underlying development of this disease. Recently, however, major advances have been made in understanding both androgen receptor (AR) dependent and independent pathways which promote development of hormone resistant prostate cancer. This review will focus on modifications to the AR and associated pathways. Molecular modifications to the androgen receptor itself, e.g. mutations and/or amplification, although involved in the development of hormone resistance cannot explain all cases. Phosphorylation of AR, via either Ras/MAP kinase or PI3K/Akt signal transduction pathways, have been shown to activate AR in both a ligand (androgen) dependent and independent fashion. During this review we will discuss the clinical evidence to support AR dependent pathways as mediators of hormone resistance

Superfield Approach to (Non-)local Symmetries for One-Form Abelian Gauge Theory

We exploit the geometrical superfield formalism to derive the local, covariant and continuous Becchi-Rouet-Stora-Tyutin (BRST) symmetry transformations and the non-local, non-covariant and continuous dual-BRST symmetry transformations for the free Abelian one-form gauge theory in four $(3 + 1)$-dimensions (4D) of spacetime. Our discussion is carried out in the framework of BRST invariant Lagrangian density for the above 4D theory in the Feynman gauge. The geometrical origin and interpretation for the (dual-)BRST charges (and the transformations they generate) are provided in the language of translations of some superfields along the Grassmannian directions of the six ($4 + 2)$-dimensional supermanifold parametrized by the four spacetime and two Grassmannian variables.Comment: LaTeX file, 23 page

Variational Mote Carlo Study of Flat Band Ferromagnetism -- Application to CeRh_3 B_2

A new mechanism for ferromagnetism in CeRh_3B_2 is proposed on the basis of variational Monte Carlo results. In a one-dimensional Anderson lattice where each 4f electron hybridizes with a ligand orbital between neighboring Ce sites, ferromagnetism is stabilized due to a nearly flat band which is a mixture of conduction and 4f electron states. Because of the strong spin-orbit interaction in 4f electron states, and of considerable amount of hybridization in the nearly flat band, the magnetic moments from 4f and conduction electrons tend to cancel each other. The resultant ferromagnetic moment becomes smaller as compared with the local 4f moment, and the Fermi surface in the ferromagnetic ground state is hardly affected by the presence of 4f electrons. These theoretical results are consistent with experimental observations in CeRh_3B_2 by neutron scattering and dHvA effects.Comment: to be published in J.Phys.Soc.Jp

Generalised verification of the observer property in discrete event systems

The observer property is an important condition to be satisfied by abstractions of Discrete Event Systems (DES) models. This paper presents a generalised version of a previous algorithm which tests if an abstraction of a DES obtained through natural projection has the observer property. The procedure called OP-verifier II overcomes the limitations of the previously proposed verifier while keeping its computational complexity. Results are illustrated by a case study of a transfer line system

Generalised verification of the observer property in discrete event systems

The observer property is an important condition to be satisfied by abstractions of Discrete Event Systems (DES) models. This paper presents a generalised version of a previous algorithm which tests if an abstraction of a DES obtained through natural projection has the observer property. The procedure called OP-verifier II overcomes the limitations of the previously proposed verifier while keeping its computational complexity. Results are illustrated by a case study of a transfer line system

Absolutely anticommuting (anti-)BRST symmetry transformations for topologically massive Abelian gauge theory

We demonstrate the existence of the nilpotent and absolutely anticommuting Becchi-Rouet-Stora-Tyutin (BRST) and anti-BRST symmetry transformations for the four (3 + 1)-dimensional (4D) topologically massive Abelian U(1) gauge theory that is described by the coupled Lagrangian densities (which incorporate the celebrated (B \wedge F) term). The absolute anticommutativity of the (anti-) BRST symmetry transformations is ensured by the existence of a Curci-Ferrari type restriction that emerges from the superfield formalism as well as from the equations of motion that are derived from the above coupled Lagrangian densities. We show the invariance of the action from the point of view of the symmetry considerations as well as superfield formulation. We discuss, furthermore, the topological term within the framework of superfield formalism and provide the geometrical meaning of its invariance under the (anti-) BRST symmetry transformations.Comment: LaTeX file, 22 pages, journal versio