Defining the intelligent public sector construction client

Recent efforts and aspirations to transform the delivery of major capital programmes and projects in UK public sector construction by focussing on achievement of value for money, whole life asset management and sustainable procurement have led to the adoption of integrated procurement routes characterised by multiplicity of stakeholders with a diversity of differing and often competing requirements. A study of the challenges faced by the public sector to deliver present and future major capital programmes and projects gravitates to the role of the intelligent client, and concomitant skills and capabilities. The results of the multiple case studies research show that the challenges of this role are especially evident at the interface between the internal organisation and the external suppliers and advisors from the private sector. The research concludes that the intelligent client role requires an individual champion with a unique set of skills working in an environment of a supporting team and capable organisation

Anorectal malformations in Mulago Hospital, Kampala-Uganda

Background: Anorectal malformations (ARM) are common congenital abnormalities in most parts of the world. Their incidence is similar to various geographical locations. This study was aimed at determining the pattern and the outcome of treatment of ARM seen at Mulago Hospital.Methods: The following review is based on clinical experience of 96 patients who presented with ARM between 1999 and 2001 at Mulago Hospital.Results: There were 389 cases of congenital abnormalities seen in three years of which 96 (24.7%) had anorectal malformations. There were 30 (31.3%) cases of low ARM. There were 66(68.7%) high ARM. The commonest operation done was Posterior Anal Transfer (PAT) with or without initial colostomy. The outcome was graded as good in most cases. The commonest complication was stenosis of the neo-anus, which was attributed to delayed closure of colostomy.Conclusion: Anorectal malformations are common in Mulago Hospital. The high variety is commoner than the low variety of ARM. Posterior Anal Transfer gives good results

The Abominable Traffic: The Abolition Movement and Emotions

It is obvious that emotions play an important role in social movement campaigns. Strangely enough, however, studies of social movements do not pay much attention to emotions nor do they give them an appropriate place in social movement theory. As Hunt and Benford contend, this overly rationalistic theory urgently needs a 'dramaturgical infusion'. In this paper we follow their lead. In it we explore historical studies of the first public campaign of the eighteenth-century abolition movement in Great Britain to shed light on the role of emotions in movement discourses. Following Hochschild we assume that each society and each culture has its unique emotional dictionary, which defines what is and isn't, and its emotional bible, which defines what one should and should not feel in a given context." In social movement campaigns, actors employ the emotional repertoires of their society in order to express their indignation, to evoke emotional feelings in the audiences they address and thus put pressure on authorities to change their policies. The analysis of the first public campaign of the British abolition movement shows that the feelings about the abolition of the slave trade often ran high. Both the abolitionists and their opponents used a great variety of emotion signs as means to communicate with the world of politics and with society at large. The analysis reveals that four variables determined the degree of emotionality in the abolition discourse. First, the nature of the cause, i.e., abolition of the slave trade. Particularly, the degree of inequality involved in slavery determined the level of moral indignation that fueled the abolition campaign. Second, the strategic-instrumental choices of the leading movement actors when to use emotional arguments and when to revert to more 'business-like' pleas. Third, the cultural climate in which a campaign takes place. In this case the cultural climate of the late eighteenth century contributed much to the emotionality of the abolition discourse. Fourth, the emotional tone of the discourses in extant critical communities, i.e., in the debates initiated by critical thinkers about a topic. In the case of abolition, the pre-dominantly emotional debate that took place within religious, particularly Evangelical, circles did much to make the abolition discourse a heated one. The analysis shows that emotions are essential to get a movement started and to keep it going. They therefore deserve scholarly attention in their own right and must not be taken granted as folklore of movement campaigns

Between Old and New: Social Movements and Cultural Change

Social movements challenge authorities on behalf of people whose needs and interests are not catered for in society. To do this, they have to accomplish a contradictory task, i.e., frame the cause of the excluded in interpre-tive packages that are contrary to the dominant views in society while at same time struggle to make these contrary views part of the dominant culture. Therefore, SMOs initiate public discourses on these interests out of which cultural changes may proceed, and if they succeed, they act as producers of new meanings. At the same time, however, the interpretive packages have to resonate with extant cultural views in order to be convincing for movement participants as well as authorities and publics. In other words, these packages have to be contrary to and correspon-ding with dominant views. How do movement actors succeed in this seemingly impossible task? Our review of cultural studies of social movements points to two strategies: (1) linking controversial topics like abortion with generally accepted and valued notions like basic rights; (2) associating their interpretive packa-ge, such as protecting the ecology, with an existing theme, such as harmony with nature, that as an alternative cultural context may legitimate their package. We use a case study, the movement against the slave trade in Great Britain, to test these propositions. The case material confirms their utility, but also reveals a third strategy: relating the package to cultural themes that are on their way to dominance. The material points to the importance of this strategy and of the role the - changing - cultural context plays in producing new meanings. The findings lead to a discussion about the role of movement actors, the cultural context, and the changes therein in the production of meaning

Prevalence and patterns of undescended testis among primary school pupils in Kampala, Uganda

A cross sectional study was undertaken with the main objective of determining the prevalence and patterns of undescended testis (UDT) among 437 primary  School pupils from randomly selected primary schools in one Division of  ampala in Uganda. The study variables included age, tribe, scrotal findings, side and location of the undescended testis plus associated groin and external genitalia abnormalities. UDT was found in 27 of the 437 children. The right side alone was involved in 17 (63%), the left alone in 5 (18.5%) and was bilateral in five cases (18.5%). Sixteen (59%) of UDT were palpable in the inguinal region while in 11 (41%) could not be palpated. Ultrasonography of the groin area located five of the 11 impalpable testes. This study showed that the prevalence of UDT in the study population was 5.5% and occurred more commonly on the right side and the superficial inguinal pouch was the commonest site.Key words: Prevalence, pattern. Undescended and testis

Expression of chemokines on the surface of different human endothelia

Expression of chemokines at the endothelial surface depends on their rate of synthesis, the capacity of the endothelium to bind chemokines and the rate of clearance from the surface. The aim of this study was to establish how these factors depend on the chemokine and the tissue of origin of the endothelium. Human lung and dermal microvascular endothelium, saphenous and umbilical vein endothelium, and a bone marrow endothelial line were assayed in vitro. Chemokine expression, localization and transport was measured by immunoassay and confocal microscopy. All endothelia bound CCL3 (MIP-1), CCL5 (RANTES) and CXCL10 (IP-10). CCL3 and CCL5 bound at high levels, and CXCL10 bound less strongly. However, the profile of chemokine expression varied between endothelia, and different chemokines were shown to bind to the endothelial surface by distinct mechanisms. The half-life of CCL3 and CCL5 at the cell surface was approximately 30 min and chemokines were cleared primarily by endocytosis into caveolae. Endothelia from different tissues synthesize distinctive sets of chemokines, but the profile of surface-expressed chemokines also depends on the distinctive characteristics of each endothelia. These two mechanisms may contribute to the differential recruitment of leucocyte subsets to different tissues

Foraging ecology of the South Australian glossy black-cockatoo ( Calyptorhynchus lathami halmaturinus )

The endangered South Australian glossy black-cockatoo ( Calyptorhynchus lathami halmaturinus Mathews 1912) feeds almost exclusively on the seeds of the drooping sheoak ( Allocasuarina verticillata ), and shows marked preferences for individual trees. This field study investigated foraging ecology and tree selection through observations of foraging birds and measurements of trees and seed cones. The cockatoos spent the vast majority of their foraging time (94%) handling seed cones, and handling behaviour was highly stereotyped. Handling time per cone was correlated primarily with cone size, while seed intake rate was correlated primarily with seed mass per cone. The cockatoos fed mostly in trees with signs of previous feeding. They tended initially to sample trees with large seeds, and to stay for long feeding bouts in trees with high ratios of seed-to-cone mass. As a result of these biases, feeding was concentrated in trees with high seed mass per cone. Preferred trees were also larger, with higher ratios of seed-to-cone mass and larger seeds containing more lipid and protein. By feeding from selected trees the cockatoos increased both their seed intake rate and the nutritional quality of the seeds ingested, thereby increasing their energy intake rate by an estimated 28%. They did not discriminate against trees that had re-grown from basal shoots after fires. Insect larvae were present in some seed cones but the cockatoos did not appear to actively seek them. Males foraged 19% more efficiently than females, resulting in greater daily food intake. The characteristics of individual A. verticillata trees that determined the cockatoos' feeding rates were also correlated with their distribution on a regional scale. This suggests that the distribution of this endangered cockatoo depends not only on the presence of food trees, but also on their regionally varying feeding profitability.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72786/1/j.1442-9993.2000.tb00003.x.pd

A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions [version 1; referees: 2 approved with reservations]

The aim of this study was to develop a three-dimensional (3D) model of the human blood-brain barrier in vitro, which mimics the cellular architecture of the CNS and could be used to analyse the delivery of nanoparticles to cells of the CNS. The model includes human astrocytes set in a collagen gel, which is overlaid by a monolayer of human brain endothelium (hCMEC/D3 cell line). The model was characterised by transmission electron microscopy (TEM), immunofluorescence microscopy and flow cytometry. A collagenase digestion method could recover the two cell types separately at 92-96% purity. Astrocytes grown in the gel matrix do not divide and they have reduced expression of aquaporin-4 and the endothelin receptor, type B compared to two-dimensional cultures, but maintain their expression of glial fibrillary acidic protein. The effects of conditioned media from these astrocytes on the barrier phenotype of the endothelium was compared with media from astrocytes grown conventionally on a two-dimensional (2D) substratum. Both induce the expression of tight junction proteins zonula occludens-1 and claudin-5 in hCMEC/D3 cells, but there was no difference between the induced expression levels by the two media. The model has been used to assess the transport of glucose-coated 4nm gold nanoparticles and for leukocyte migration. TEM was used to trace and quantitate the movement of the nanoparticles across the endothelium and into the astrocytes. This blood-brain barrier model is very suitable for assessing delivery of nanoparticles and larger biomolecules to cells of the CNS, following transport across the endothelium

\u3ci\u3eThemeda triandra\u3c/i\u3e as a Perennial Seed Crop in South-Eastern Australia: What are the Agronomic Possibilities and Constraints, and Future Research Needs?

In Australia, the development of native perennial seed crops is an area of increasing interest. Reasons for this include the production of high-value seed, the significance of native plants to Aboriginal people and the importance of diversified cropping in building more resilient farming systems. One species of interest is Themeda triandra, a C4 perennial tussock grass that dominated grasslands and woodlands across Australia prior to European invasion. Djaara, the traditional owner group representing the Dja Dja Wurrung people of Djandak (Dja Dja Wurrung country in central Victoria), is one group who seek to return T. triandra to the landscape as a seed-producing crop. This is due to the species holding for them significant cultural and social value, along with envisioned future economic opportunities. As such, this review is targeted towards temperate grasslands of south-eastern Australia where Djandak is located. This review summarises the agronomic possibilities and constraints relating to production of a T. triandra as a seed crop via an understanding of the genetic, environmental and management factors that influence the growth, development, and seed yield of this species. Future research and development needs are also identified