Digital Currency: The Future of Money

Digital currency is one of the hottest topics in the world right now. This is more so in India due to the recent demonetization schemes by the government. Due to that, many people have started using online banking, digital wallets, digital currency among others. Although there is knowledge out there about the digital wallets and online banking, the knowledge about digital currencies like Bitcoin is either minimal or next to none. This paper intends to give an overview of the various digital currencies. That includes explaining what Digital Currency really is, its processing, the real life working and the factors affecting the adoption of such currencies. How the various transactions that include digital currencies take place is one of the major points of focus of the paper. The various risks involved in such transactions are also listed in the paper

Critical Assessment of Infrastructure Investment Trusts (InvITs) in India and Suggesting measures to increase their Efficiency in comparison with International Instruments

Indian economy, like any other economy, relies heavily on the infrastructure sector. However, by end of 12th five-year plan (2012-2017) private sector investment in infrastructure started declining causing increase in government spending through budgetary support. To boost investment in infrastructure, Securities Exchange Board of India (SEBI) came up with Infrastructure Investment Trust (InvIT) regulations in 2014. InvIT’s are trust holding infrastructure assets that generate steady cash flow with long term concession. The structure of InvIT is similar to Master-Business Trusts instruments that are prevalent in many developed countries like UK, USA, Singapore, Australia & Hong-Kong. They are listed on stock exchange by issuing their units to investors. While interest of investors have increased in recent past, India\u27s progress in InvIT is still at a relatively nascent stage. As on date, around 10 (ten) InvITs are registered with SEBI. In this study we have attempted to do a critical assessment of the market for InvIT in India. We have also evaluated regulations that regulate InvIT in India and compared them with similar International instruments in order to enhance its attractiveness

Introductory Physics I & II (MGA)

This Grants Collection for Introductory Physics I & II was created under a Round Four ALG Textbook Transformation Grant. Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/physics-collections/1002/thumbnail.jp

Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention

Alcohol and other drugs of abuse, including psychostimulants and opioids, can induce epigenetic changes: a contributing factor for drug addiction, tolerance and associated withdrawal symptoms. DNA methylation is the major epigenetic mechanism and it is one of more than 200 methylation reactions supported by methyl donor S-adenosylmethionine (SAM). The levels of SAM are controlled by cellular redox status via the folate and vitamin B12-dependent enzyme methionine synthase (MS), for example; under oxidative conditions MS is inhibited, diverting its substrate homocysteine (HCY) to the transsulfuration pathway. Alcohol, dopamine and morphine, can alter intracellular levels of glutathione (GSH)-based cellular redox status, subsequently affecting S-adenosylmethionine (SAM) levels and DNA methylation status. In this discussion, we compile this and other existing evidence in a coherent manner to present a novel hypothesis implicating the involvement of redox-based epigenetic changes in drug addiction. Next, we also discuss how gene priming phenomenon can contribute to maintenance of redox and methylation status homeostasis under various stimuli including drugs of abuse. Lastly, based on our hypothesis and some preliminary evidence, we discuss a mechanistic explanation for use of metabolic interventions / redox-replenishers as symptomatic treatment of alcohol addiction and associated withdrawal symptoms. Hence, the current review article strengthens the hypothesis that neuronal metabolism has a critical bidirectional coupling with epigenetic changes in drug addiction and we support this claim via exemplifying the link between redox-based metabolic changes and resultant epigenetic consequences under the effect of drugs of abuse

Zero Entropy Interval Maps And MMLS-MMA Property

We prove that the flow generated by any interval map with zero topological entropy is minimally mean-attractable (MMA) and minimally mean-L-stable (MMLS). One of the consequences is that any oscillating sequence is linearly disjoint with all flows generated by interval maps with zero topological entropy. In particular, the M\"obius function is orthogonal to all flows generated by interval maps with zero topological entropy (Sarnak's conjecture for interval maps). Another consequence is a non-trivial example of a flow having the discrete spectrum.Comment: 12 page

Role of a Redox-Based Methylation Switch in mRNA Life Cycle (Pre- and Post-Transcriptional Maturation) and Protein Turnover: Implications in Neurological Disorders

Homeostatic synaptic scaling in response to neuronal stimulus or activation, and due to changes in cellular niche, is an important phenomenon for memory consolidation, retrieval, and other similar cognitive functions (Turrigiano and Nelson, 2004). Neurological disorders and cognitive disabilities in autism, Rett syndrome, schizophrenia, dementia, etc., are strongly correlated to alterations in protein expression (both synaptic and cytoplasmic; Cajigas et al., 2010). This correlation suggests that efficient temporal regulation of synaptic protein expression is important for synaptic plasticity. In addition, equilibrium between mRNA processing, protein translation, and protein turnover is a critical sensor/trigger for recording synaptic information, normal cognition, and behavior (Cajigas et al., 2010). Thus a regulatory switch, which controls the lifespan, maturation, and processing of mRNA, might influence cognition and adaptive behavior. Here, we propose a two part novel hypothesis that methylation might act as this suggested coordinating switch to critically regulate mRNA maturation at (1) the pre-transcription level, by regulating precursor-RNA processing into mRNA, via other non-coding RNAs and their influence on splicing phenomenon, and (2) the post-transcription level by modulating the regulatory functions of ribonucleoproteins and RNA binding proteins in mRNA translation, dendritic translocation as well as protein synthesis and synaptic turnover. DNA methylation changes are well recognized and highly correlated to gene expression levels as well as, learning and memory; however, RNA methylation changes are recently characterized and yet their functional implications are not established. This review article provides some insight on the intriguing consequences of changes in methylation levels on mRNA life-cycle. We also suggest that, since methylation is under the control of glutathione anti-oxidant levels (Lertratanangkoon et al., 1997), the redox status of neurons might be the central regulatory switch for methylation-based changes in mRNA processing, protein expression, and turnover. Lastly, we also describe experimental methods and techniques which might help researchers to evaluate the suggested hypothesis

Cislunar Satellite Constellation Design Via Integer Linear Programming

Cislunar space awareness is of increasing interest to the international community as Earth-Moon traffic is projected to increase. This raises the problem of placing satellites optimally in a constellation to provide satisfactory coverage for said traffic. The Circular Restricted 3 Body Problem (CR3BP) provides promising periodic orbits in the Earth-Moon rotating frame for traffic monitoring. This work converts a spatially and temporally varying traffic coverage requirement into an integer linear programming problem, attempting to minimize the number of satellites required for the requested coverage.Comment: 18 pages, 15 figures, submitted to 2023 AAS Conferenc