Deformation mechanisms and damage of oxide dispersion strengthened steels at high temperature

International audienceA ferritic oxide dispersion strengthened steel is under study for fuel cladding applications in future nuclear systems. Tensile tests and creep tests are carried out at various temperatures to determine its mechanical properties along the extrusion direction. For these two types of loading, the material exhibits a high mechanical resistance. Its ductility appears to be strongly influenced by the strain rate and the temperature. Deformation mechanisms linked to diffusion phenomena are suspected and intergranular damage is observed on fractured specimens

Precipitation kinetics analysis of oxide dispersion strengthened steels for their application as cladding material in Gen.IV power plants

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Assesment of potential swelling of Pressurized Water Reactor internals The GONDOLE experiment in Osiris reactor

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Comportement mécanique à haute température des aciers martensitiques revenus pour application aux réacteurs à neutrons rapides

National audienceLa conception du futur réacteur à neutrons rapides à caloporteur sodium (SFR) a motivé de nombreuses études sur le comportement en fatigue, fluage et fatigue-fluage à haute température d'aciers martensitiques revenus (450-600°C). Depuis les années 80, l'instab ilité de leur microstructure dans certaines conditions de chargement (fatigue, fluage) a été mise en évidence dans la littérature. Cette instabilité conduit à un adoucissement qu'il convient de comprendre et de prédire. Nous avons particulièrement étudié l'effet des chargements caractéristiques des conditions en service auxquelles seront soumis les composants du réacteur SFR (faibles amplitudes de déformation cycliques, longues durées de vie en fluage), pour lesquelles les données expérimentales sont rares. Des évolutions microstructurales et un adoucissement notable ont été mis en évidence dans ces conditions. Des modèles micromécaniques basés sur les densités de dislocations continus permettent de prédire qualitativement un grand nombre des phénomènes observés

High temperature mechanical strength and microstructural stability of advanced 9-12%Cr steels and ODS steels

International audienceThe present study proposes a comparison between several martensitic and ferritic steels in terms of creep strength and cyclic softening effect. The damage mechanisms are identified using fractographic observations and the microstructural evolutions are observed by TEM. The effects of a modified chemical composition on the high temperature mechanical behaviour are studied

Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer’s disease patients

International audienceIdentification of blood-based biomarkers of Alzheimer’s disease (AD) remains a challenge. Neuropathological studies have identified enlarged endosomes in post-mortem brains as the earliest cellular change associated to AD. Here the presence of enlarged endosomes was investigated in peripheral blood mononuclear cells from 48 biologically defined AD patients (25 with mild cognitive impairment and 23 with dementia (AD-D)), and 23 age-matched healthy controls using immunocytochemistry and confocal microscopy. The volume and number of endosomes were not significantly different between AD and controls. However, the percentage of cells containing enlarged endosomes was significantly higher in the AD-D group as compared with controls. Furthermore, endosomal volumes significantly correlated to [C11]PiB cortical index measured by positron emission tomography in the AD group, independently of the APOE genotype, but not to the levels of amyloid-beta, tau and phosphorylated tau measured in the cerebrospinal fluid. Importantly, we confirmed the presence of enlarged endosomes in fibroblasts from six unrelated AD-D patients as compared with five cognitively normal controls. This study is the first, to our knowledge, to report morphological alterations of the endosomal compartment in peripheral cells from AD patients correlated to amyloid load that will now be evaluated as a possible biomarker

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD

Identification of Novel Functional Inhibitors of Acid Sphingomyelinase

We describe a hitherto unknown feature for 27 small drug-like molecules, namely functional inhibition of acid sphingomyelinase (ASM). These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to treat diseases associated with enhanced activity of ASM, such as Alzheimer's disease, major depression, radiation- and chemotherapy-induced apoptosis and endotoxic shock syndrome. Residual activity of ASM measured in the presence of 10 µM drug concentration shows a bimodal distribution; thus the tested drugs can be classified into two groups with lower and higher inhibitory activity. All FIASMAs share distinct physicochemical properties in showing lipophilic and weakly basic properties. Hierarchical clustering of Tanimoto coefficients revealed that FIASMAs occur among drugs of various chemical scaffolds. Moreover, FIASMAs more frequently violate Lipinski's Rule-of-Five than compounds without effect on ASM. Inhibition of ASM appears to be associated with good permeability across the blood-brain barrier. In the present investigation, we developed a novel structure-property-activity relationship by using a random forest-based binary classification learner. Virtual screening revealed that only six out of 768 (0.78%) compounds of natural products functionally inhibit ASM, whereas this inhibitory activity occurs in 135 out of 2028 (6.66%) drugs licensed for medical use in humans