Teacher Demand Driven Policy: Implications on Retention and Equity in the Distribution of Teachers in Secondary Schools in Busia County, Kenya.

In   Kenya, Teacher Demand driven Policy was introduced in 2001 as a reform policy to improve equity in the distribution and retention of teachers. Despite this attempt, the challenge of equitable distribution and retention of teachers persist thereby affecting the quality of education. This study examined the teacher demand recruitment policy only, it’s implication on retention and equity in the distribution of teacher in public secondary schools in Busia County, Kenya. The study was guided by economic labor movement theory of supply and demand. The study adapted a descriptive research design and employed mixed methods. The target population comprised 1359 teachers and one County Staffing Officer (CSO). Stratified random technique was used to result 245 teachers, 32 deputy principals and 32 principals while census was used to select one CSO in Busia County. Data was corrected by using questionnaire and interview schedule. Validity was established by expert opinion while test and retest method was used to establish reliability. Data was analyzed using descriptive and inferential statistics. The findings revealed that teacher retirement rates, increase in student enrolment, subject areas, school factors and teacher attrition influenced the demand driven recruitment policy in Busia County. Retention and equity in the distribution of teachers was demonstrated through teacher satisfaction, staffing level, commitment, turnover rate and performance. Further, demand driven recruitment policy had more significant association with equity and distribution of teachers (χ2 (12, N = 239) = 122.881, p = 0.000) than with their retention (χ2 (12, N = 239) = 75.407, p = 0.000). Similarly, teacher characteristics such as qualifications, ethnicity, gender and socio-economic status influenced equitable distribution more as compared to their retention. However, age of the teacher influenced their retention more as compared to the equity in the distribution. The study concluded that demand driven recruitment policy has resulted to equity in the distribution of teachers in Busia County. However, the study recommended that policies and regulations need to be developed to enhance their retention after recruitment by the Teachers Service Commission (TSC). Keywords:Demand driven ,retention and equit

Factors associated with stunting in Dodoma region, Tanzania

Child undernutrition is a major public health concern, claiming the lives of numerous children below five years of age in the developing world. The objective of this study was to assess the factors associated with stunting of children of age 6 – 23 months in Dodoma Municipality and Chamwino District in Dodoma region. Dodoma region located in the central zone of Tanzania was chosen for this study because of its high prevalence (56%) of stunting among children under five years of age. A systematic random sampling technique was used to choose wards, villages, and households that had children aged 6 - 23 months, resulting in 394 households participating in this cross-sectional study. A standardized questionnaire was used to collect socio-demographic information and infant feeding practices. Anthropometric measurements were taken as per WHO standard procedures. A repeated 24-hour dietary recall was used to assess food intake among the study population. Multivariate logistic regression using backward stepwise selection method was used to obtain independent factors of stunting. The overall prevalence of stunting was 40.4% (95% CI; 29.8; 50.9), Chamwino District had a higher prevalence of stunting (44.3%) compared to Dodoma municipality (26.3%). Multivariate logistic regression analysis showed that, age of introduction of complementary food [AOR = 13.3; (95% CI: 2.6 – 67.6)], maternal education [AOR = 5.5; (95% CI: 1.0 – 9.8)], residence in Chamwino District [AOR = 3.2; (95% CI: 1.3 – 5.9)] were factors associated with stunting. About half of the study population (49%) was introduced to complementary foods early, the median age was four months instead of 6 months as recommended by WHO. Infant’s diet was mainly cereal-based, other foods such as animal food source, fruits, and dairy products were consumed by 18%, 11% and 7.1% of children respectively. The dietary pattern of infants was not diversified as 47.7% of infants scored 1 to 3 points out of 12 points categorized as low dietary diversity. Failure to attain normal growth pattern is the most prevalent form of undernutrition in childhood. Associated factors are many, diverse and interrelated. The present study identified maternal education, early introduction of complementary foods and being a resident of Chamwino District as factors to be associated with stunting. Prioritization of identified factors serves as a highlight for better planning of nutrition intervention programs that intend to promote child growth.Key words: Stunting, nutrition status, 6 – 23 months, dietary diversity and complementary foo

An Analysis of Loan Portfolio Management on Organization Profitability: Case of Commercial Banks in Kenya

The banking sector in any economy serves as a catalyst for growth and development. Banks are able to perform this role through their crucial functions of financial intermediation, provision of an efficient payment system and facilitating the implementation of monetary policies. Bank profitability is usually expressed as a function of internal and external determinants. The overall performance and profitability of the banking sector in Kenya has improved tremendously over the last 10 years. The aim of this study was to close the gap in knowledge by investigating profitability determinants within commercial banks in Kenya. The determinants studied were loan portfolio, interest expense, and administration costs and assets value. A descriptive survey design was employed in this study. The population of the study was the management employees working for commercial banks in Kenya. The sample was accessed by use of both stratified and simple random sampling. A questionnaire was used to gather the primary information. The questionnaires were self-administered and were served to the respondents by self-introduction. Research assistants were used to follow up on duly completed questionnaires. Statistical package for social sciences (SPSS) was used to analyse primary data while the SAS v.6 of 2009 was used to analyse the secondary data gathered from the banks. Findings of the study showed that public sector banks and private sector banks were not much affected by increasing or decreasing of interest margin. It can therefore be interpreted that the profitability growth of public and private sector banks are not dependent on fluctuation of interest rate although the foreign banks have the benefit of high return due to increase or decrease in interest margin. Key Words: Loan portfolio Management on organization profitability, commercial Banks in Keny

Temporal changes in the positivity rate of common enteric viruses among paediatric admissions in coastal Kenya, during the COVID-19 pandemic, 2019–2022

Background: The non-pharmaceutical interventions (NPIs) implemented to curb the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronavirus disease 2019 (COVID-19) pandemic, substantially disrupted the activity of other respiratory viruses. However, there is limited data from low-and-middle income countries (LMICs) to determine whether these NPIs also impacted the transmission of common enteric viruses. Here, we investigated the changes in the positivity rate of five enteric viruses among hospitalised children who presented with diarrhoea to a referral hospital in coastal Kenya, during COVID-19 pandemic period. Methods: A total of 870 stool samples from children under 13 years of age admitted to Kilifi County Hospital between January 2019, and December 2022 were screened for rotavirus group A (RVA), norovirus genogroup II (GII), astrovirus, sapovirus, and adenovirus type F40/41 using real-time reverse-transcription polymerase chain reaction. The proportions positive across the four years were compared using the chi-squared test statistic. Results: One or more of the five virus targets were detected in 282 (32.4%) cases. A reduction in the positivity rate of RVA cases was observed from 2019 (12.1%, 95% confidence interval (CI) 8.7–16.2%) to 2020 (1.7%, 95% CI 0.2–6.0%; p < 0.001). However, in the 2022, RVA positivity rate rebounded to 23.5% (95% CI 18.2%–29.4%). For norovirus GII, the positivity rate fluctuated over the four years with its highest positivity rate observed in 2020 (16.2%; 95% C.I, 10.0–24.1%). No astrovirus cases were detected in 2020 and 2021, but the positivity rate in 2022 was similar to that in 2019 (3.1% (95% CI 1.5%–5.7%) vs. 3.3% (95% CI 1.4–6.5%)). A higher case fatality rate was observed in 2021 (9.0%) compared to the 2019 (3.2%), 2020 (6.8%) and 2022 (2.1%) (p < 0.001). Conclusion: Our study finds that in 2020 the transmission of common enteric viruses, especially RVA and astrovirus, in Kilifi Kenya may have been disrupted due to the COVID-19 NPIs. After 2020, local enteric virus transmission patterns appeared to return to pre-pandemic levels coinciding with the removal of most of the government COVID-19 NPIs

Genomic epidemiology of Human Adenovirus F40 and F41 in Coastal Kenya : a retrospective hospital-based surveillance study (2013-2022)

Human adenovirus species F (HAdV-F) is a leading cause of childhood diarrhoeal deaths. Genomic analysis would be key for understanding transmission dynamics, potential drivers of disease severity, transmission dynamics, and for vaccine development. However, currently there are limited HAdV-F genomic data globally. Here, we sequenced and analysed HAdV-F from stool samples collected in coastal Kenya between 2013 and 2022. The samples were collected at Kilifi County Hospital in coastal, Kenya, from children &amp;lt; 13 years of age who reported a history of ≥ 3 loose stools in the previous 24hrs. The genomes were analyzed together with data from the rest of the world by phylogenetic analysis and mutational profiling. Types and lineages were assigned based on phylogenetic clustering consistent with previously described criteria and nomenclature. Participant clinical and demographic data were linked to genotypic data. Of 91 cases identified using real-time PCR, 88 near-complete genomes were assembled, and these classified into HAdV-F40 (n=41) and F41 (n=47). These types cocirculated throughout the study period. Three and four distinct lineages were observed for HAdV-F40 (Lineage 1-3) and F41 (Lineage 1, 2A, 3A, 3C and 3D). Types F40 and F41 coinfections were observed in five samples, and F41 and B7 in one sample. Two children with F40 and 41 coinfections were also infected with rotavirus and had moderate and severe disease as defined using the Vesikari Scoring System, respectively. Intratypic recombination was found in 4 HAdV-F40 sequences occurring between lineages 1 and 3. None of the HAdV-F41 cases had jaundice. This study provides evidence of extensive genetic diversity, coinfections, and recombination within HAdV-F40 in a rural coastal Kenya that will inform public health policy, vaccine development that includes the locally circulating lineages, and molecular diagnostic assay development. We recommend future comprehensive studies elucidating on HAdV-F genetic diversity and immunity for rational vaccine development

Optimization of the SARS-CoV-2 ARTIC network V4 primers and whole genome sequencing protocol

Introduction: The ARTIC Network's primer set and amplicon-based protocol is one of the most widely used SARS-CoV-2 sequencing protocol. An update to the V3 primer set was released on 18th June 2021 to address amplicon drop-off observed among the Delta variant of concern. Here, we report on an in-house optimization of a modified version of the ARTIC Network V4 protocol that improves SARS-CoV-2 genome recovery in instances where the original V4 pooling strategy was characterized by amplicon drop-offs. Methods: We utilized a matched set of 43 clinical samples and serially diluted positive controls that were amplified by ARTIC V3, V4 and optimized V4 primers and sequenced using GridION from the Oxford Nanopore Technologies'. Results: We observed a 0.5% to 46% increase in genome recovery in 67% of the samples when using the original V4 pooling strategy compared to the V3 primers. Amplicon drop-offs at primer positions 23 and 90 were observed for all variants and positive controls. When using the optimized protocol, we observed a 60% improvement in genome recovery across all samples and an increase in the average depth in amplicon 23 and 90. Consequently, ≥95% of the genome was recovered in 72% (n = 31) of the samples. However, only 60–70% of the genomes could be recovered in samples that had 0.05) correlation between Ct value and genome recovery. Conclusion: Utilizing the ARTIC V4 primers, while increasing the primer concentrations for amplicons with drop-offs or low average read-depth, greatly improves genome recovery of Alpha, Beta, Delta, Eta and non-VOC/non-VOI SARS-CoV-2 variants

Genomic epidemiology of the rotavirus G2P[4] strains in coastal Kenya pre- and post-rotavirus vaccine introduction, 2012 – 2018

The introduction of rotavirus vaccines into the national immunization programme in many countries has led to a decline of childhood diarrhoea disease burden. Coincidentally, the incidence of some rotavirus group A (RVA) genotypes, has increased, which may result from non-vaccine-type replacement. Here we investigate the evolutionary genomics of rotavirus G2P[4] which has shown an increase in countries that introduced the monovalent Rotarix® vaccine. We examined 63 RVA G2P[4] strains sampled from children (aged below 13 years) admitted to Kilifi County Hospital, Coastal Kenya, pre- (2012 to June 2014) and post-(July 2014-2018) rotavirus vaccine introduction. All the 63 genome sequences showed a typical DS-1 like genome constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Pre-vaccine G2 sequences predominantly classified as sub-lineage IVa-3 and co-circulated with low numbers of sub-lineage IVa-1 strains, whereas post-vaccine G2 sequences mainly classified into sub-lineage IVa-3. In addition, in the pre-vaccine period, P[4] sub-lineage IVa strains co-circulated with low numbers of P[4] lineage II strains, but P[4] sub-lineage IVa strains predominated in the post-vaccine period. On the global phylogeny, the Kenyan pre- and post-vaccine G2P[4] strains clustered separately, suggesting that different virus populations circulated in the two periods. However, the strains from both periods exhibited conserved amino acid changes in the known antigenic epitopes, suggesting that replacement of the predominant G2P[4] cluster was unlikely a result of immune escape. Our findings demonstrate that the pre- and post-vaccine G2P[4] strains circulating in Kilifi, coastal Kenya, differed genetically, but likely were antigenically similar. This information informs the discussion on the consequences of rotavirus vaccination on rotavirus diversity

Managing emerging fisheries of the North Kenya Banks in the context of environmental change

The North Kenya Banks have long been considered an important emerging fishery with the potential to spur economic growth for local fishing communities. As a regionally important extension to the otherwise narrow East African continental shelf, the North Kenya Banks remain under studied with implications for efforts to develop a sustainable fisheries management strategy. The local marine ecosystem is known to be strongly influenced by wind driven upwelling processes with seasonal variability driven by the changing monsoon seasons being of particular importance. Nevertheless, the Western Indian Ocean is warming due to anthropogenic climate change with evidence indicating reduced ocean productivity in future. How the ecosystem of the North Kenya Banks will respond is currently uncertain but is of great importance due to the significance of coastal fishery resources to coastal communities, and growing Blue Economy initiatives to exploit the North Kenya Banks fisheries more widely. There is, however, limited knowledge of the processes influencing productivity over the North Kenya Banks regions and currently there is no management plan in place to sustainably manage the fishery resources. Here, information about the North Kenya Banks fisheries are examined in relation to environmental processes and threats from climate change impacts with suggestions for future research and management directions

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century