Synthesis, Crystal Structures of S- and N- Benzyl Derivatives Of 5-phenyl-1,3,4-oxadiazol-2-thione

Benzylation reaction is carried out 5-phenyl-1,3,4-oxadiazol-2-thione with benzyl chloride in acetone and HMPA. In the acetone was obtained exclusively S-benzyl derivative and in the case of HMPA - isomeric mixture of S- and N-benzyl derivatives were obtained, individually isolated, characterized, and their structure was proved by spectral methods. By slow evaporation of solvents at room temperature were obtained two polymorphic crystals of 5-phenyl-1,3,4-oxadiazol-2-thione from acetone 1 and ethanol 2. Crystals of 2-benzylthio-5-phenyl-1,3,4-oxadiazole 3 and 3-benzyl-5-phenyl-1,3,4-oxadiazol-2-thione 4 obtained in similar conditions have structures without the inclusion of solvent molecules

Ontogenetic structure of cenopopulations of Allium pskemense (Amaryllidaceae) in Uzbekistan

Many plants of the Allium genus are economically valuable as vegetables. For example, Asian countries are the largest producers of Allium pskemense B. Fedtsch. Ontogenetic spectrum – a sensitive population indicator of changes in the environment – has been noted as useful in recording the age condition of plants. The study focused on the ontogenetic structure of five cenopopulations of A. pskemense, revealing that the examined cenopopulations growing in different ecological-coenotic environmental conditions are normal, and mainly incomplete, i.e. do not include all age groups. Their ontogenetic spectrum was left-sided, and only the coenotic populations 2, 4, 5 coincided with the characteristic spectrum. Depending on ecological-phytocoenotic living conditions, density of individuals in the studied communities ranged 1.75 to 4.50 ind./m2, whereas the ecological density was within 2.00 to 5.29 ind./m2. The research determined that the ontogenetic spectrum shifted to the centered type temporarily due to the uneven processes of the development. Similarities of biological features (long mature generative condition, prevalence of mode of reproduction by seeds, low viability of young individuals) of individuals of this species in various locations, type of cenopopulation, characteristic actual ontogenetic spectra indicate stable conditions for the studied CPs in forbs-Ziziphora-shrub (cenopopulation 5) communities in Uzbekistan

The results of open surgical treatment of bilateral staghorn and multiple nephrolithiasis

Aim. To determine the status and to increase the effectiveness of open surgical treatment of bilateral staghorn nephrolithiasis. Methods. We studied the results of surgical treatment of 250 patients who underwent open surgery for severe forms of bilateral staghorn nephrolithiasis. The patients were divided into four groups according to the features of changes in both kidneys and ureters - group 1 included 125 (50.0%) patients with bilateral staghorn nephrolithiasis, group 2 - 35 (14.0%) patients with staghorn nephrolithiasis of solitary or the only functioning kidney, 70 (28.0%) patients with unilateral staghorn nephrolithiasis and solitary or multiple kidney or ureter stones on the other side were included into group 3, and group 4 inlcuded 20 (8.0%) patients with unilateral staghorn nephrolithiasis and nonobstructive hydronephrosis and other diseases on the other side. The age of patients ranged from 7 to 76 years old, ranging among children from 7 to 18 years (average age 12.1±0.4 years) and among adults from 19 to 76 years (average age 46.4±0.6 years). Among patients, 121 (48.4%) were males and 129 (51.6%) were females. Results. Surgical tactics and the results of performed surgeries in certain groups were studied. Overall, 127 (50.8±3.8%) of 250 patients underwent surgery on the right kidney, and 123 (49.2±3.2%) - on the left kidney. To achieve minimal blood loss during the surgery, in 20% of cases renal artery was clamped. To protect kidneys from ischemia, 3 mg/kg of furosemide, 0.2 mg/kg of verapamil and 1 mg/kg of methylethylpiridinol were used before and after clamping of the renal artery. Open surgical treatment of 250 patients with bilateral staghorn nephrolithiasis was successful in 246 (98.4±0.8%) patients. In case of residual stones, extracorporeal or ureterorenoscopic shock wave lithotripsy was performed. Conclusion. Despite the wide application of modern endoscopic methods of therapy in the treatment of this group of patients, in complex forms of staghorn nephrolithiasis open surgery is more effective

Analysis of Transient Recovery Voltage and Secondary arc Current in Transposed Extra-High Voltage Lines in a Two-Phase Auto-Reclosing

Extra-high voltage (EHV) lines of 500–750 kV, providing transmission of electricity over long distances and at the same time performing the functions of intersystem communication at the level of the national power system, play an important role not only in normal modes, but also in emergency modes, ensuring the dynamic stability of the power system as a whole. In these lines, the overwhelming proportion of power cuts are caused by single-phase short circuits (90%), a significant part of which, being unstable arc faults, are successfully eliminated in the single-phase auto-reclosing cycle. Also, about 5%–10% of failures can be constituted by two-phase short circuits, which can be eliminated in a two-phase auto-reclosing cycle (TPhAR). The purpose of this paper is to study two-phase auto-reclosing in transposed EHV lines equipped with four-radial shunt reactors (ShR). The paper analyzes the efficiency of using a two-phase auto-reclosing to eliminate two-phase short-circuits in the lines connecting the power systems of Kyrgyzstan and Tajikistan. An algorithm is proposed for calculating the transient recovering voltages (TRV) and secondary arc currents (SAC) in the real transposed line Datka–Khujand–Dushanbe. The obtained results of TRV and SAC, which are within the permissible limits for the Dushanbe–Khujand line section, make it possible to have a dead time of TPhAR of no more than 0.6 s, in order to maintain the dynamic stability of the power system. For lines with a length of about 500 km (Datka–Khujand), equipped with three reactors, a successful TPhAR is impossible due to the appearance of resonant TRV in the circuit. The paper proposes the use of banks of capacitors connected in series in the phases of the ShR for the implementation of a successful TPhAR with the duration of the required pause of about 0.6 s. © 2021 The Authors

Comparative analysis of the quality indicators of bread made of composite flour using ozonated water

According to the First President of Kazakhstan, it is important to exclude any possibility of food shortages. In this regard, the primary task of the population is to create innovative technologies for the successful promotion and avoidance of food shortages. Bread is one of the most important food products in Kazakhstan. Consequently, the main task of the population of the bakery industry today is the creation of innovative technologies for functional food products. The article presents the results of an organoleptic study of the bread of innovative preparation using composite flour and ozonated water. To create a scientific basis in the production of bread "Composon", a study of organoleptic indicators was conducted. The quality of bread was assessed for compliance with the requirements of regulatory documents. The use of ion-ozone technology makes it possible to reduce environmental pollution, increase the nutritional value of bakery products, as well as reduce material and energy resources. As a result of the study, it was found that the use of ionized water with composite flour affects the improvement of organoleptic indicators of product quality: the color is more uniform, the taste and smell are pronounced and fragrant, the shape of the product is rounded, the texture of the crumb with uniform porosity. Wheat bread, which was made from composite flour and using ozonated water according to the studied technology, retains the freshness of the crumb for 48 hours, has a lower possibility of infection with potato disease, and is also characterized by good organoleptic characteristics

Synthesis, recyclization under the action of methanol and analgetic activity of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides

New methyl 5-aryl-1-(furan-2-carbonyl)-1H-pyrazole-3-carboxylates were obtained via decyclization reaction of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides under the action of methanol. Starting N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides were obtained by intramolecular cyclization of substituted 4-aryl-2-[2-(furan-2-ylcarbonyl)hydrazinylidene]-4-oxobutanoic acids in propionic anhydride. The structure of the compounds obtained was confirmed by the 1H NMR spectroscopy, IR spectrometry and elemental analysis methods. Analgesic activity of some obtained compounds was studied by the “hot plate” method on outbred white mice of both sexes with intraperitoneal injection

Determination of 3D Trajectories of Knots in Solar Prominences Using MSDP Data

In this paper we present a new method of restoration of the true thee-dimensional trajectories of the prominence knots based on ground-based observations taken with a single telescope, which is equipped with a Multi-Channel Subtractive Double Pass imaging spectrograph. Our method allows to evaluate true three-dimensional trajectories of the prominence knots without any assumptions concerning the shape of the trajectories or dynamics of the motion. The reconstructed trajectories of several knots observed in three prominences are presented.Comment: 14 pages, 9 figures, accepted for publication in Solar Physic

Perinatal outcomes in pregnant women with preeclampsia depending on vitamin D levels

The purpose of this study was to study the course of pregnanacy and assess the state of newborns, from mothers with various severity of preeclampsia, depending on the level of vitamin D. Analyzed the state of 30 pregnant women with preeclampsia and their newborns. The control group was 25 pregnant women without hypertensive disorders. Preeclampsia and the level of vitamin D statistically significantly affects not only the health of pregnant women, but also the state of health of the newbornЦелью настоящего исследования явилось изучение течение беременности и оценить состояния новорожденных, рожденных от матерей с различными тяжестими преэклампсии в зависимости от уровня витaмина D. Проанализировано состояние 30 беременных с преэклампсией и их новорожденных. Группу кoнтрoля сoстaвили 25 бeременных без гипертензивных рaсстрoйств. Преэклампсия(ПЭ) и урoвень витaминa D стaтистически знaчимo влияет не тoлькo нa здoрoвье бeременнoй, нo и сoстoяние здoрoвья нoвoрoжденнoгo. Дефицит витaминa Д снижaет блaгoприятные исхoды бeременнoст

Робот-ассистированная трансплантация почки. Первый опыт

Kidney transplantation is the preferred renal replacement therapy for patients with end-stage renal disease. Traditional surgical approaches consisting of vascular and urinary outflow reconstruction during kidney transplant have been sufficiently studied and standardized. However, surgical techniques are still evolving. The objective of this clinical report is to focus the attention of kidney transplant surgeons and specialists on the currently trending robot-assisted kidney transplantation (RAKT) as a minimally invasive procedure for surgical treatment of patients with end-stage renal disease. In our first experience, good primary graft function was achieved. This shows that RAKT is a surgical option. With considerable number of surgeries and experience, RAKT outcomes would be improved significantly.Аллотрансплантация почки в настоящее время во всем мире является предпочтительным методом заместительной терапии у пациентов с терминальной стадией поражения почечной функции. Классические хирургические принципы сосудистой реконструкции и создания мочевого оттока при пересадке почки полностью изучены и стандартизированы. Несмотря на это, эволюция хирургической техники все же является непрерывным процессом. Целью данного клинического сообщения является акцентирование внимания хирургов-трансплантологов и специалистов, занятых в лечении реципиентов почек, на отражающем современные тенденции развития хирургии виде робот-ассистированной трансплантации почки (РАТП), как на щадящем методе оперативного лечения пациентов с терминальной стадией поражения почек. Результаты первого опыта в виде хорошей первичной функции трансплантата почки демонстрируют возможность использования РАТП как варианта хирургического вмешательства. Накопление же достаточного пула проведенных операций в значительной степени улучшит результаты использования такого метода лечения

Synthesis, recyclization under the action of methanol and analgetic activity of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides

Received: 14.11.22. Revised: 21.11.22. Accepted: 21.11.22. Available online: 01.12.22.The synthesis method for obtaining methyl 5-aryl-1-(furan-2-carbonyl)-1H-pyrazole-3-carboxylates developed.Five new compounds not previously described in the literature were obtained.Some of the compounds obtained have been found to have significant analgetic effects.New methyl 5-aryl-1-(furan-2-carbonyl)-1H-pyrazole-3-carboxylates were obtained via decyclization reaction of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides under the action of methanol. Starting N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides were obtained by intramolecular cyclization of substituted 4-aryl-2-[2-(furan-2-ylcarbonyl)hydrazinylidene]-4-oxobutanoic acids in propionic anhydride. The structure of the compounds obtained was confirmed by the 1H NMR spectroscopy, IR spectrometry and elemental analysis methods. Analgesic activity of some obtained compounds was studied by the “hot plate” method on outbred white mice of both sexes with intraperitoneal injection.This study was performed under financial support of the “Rational Use of the Earth Interior” Perm Scientific Educa-tional Center 2023 and Ministry of Science and Higher education of Russian Federation FSEG-2022-0012