Human exposure to polybrominated diphenyl ethers and endocrine disruption

Thesis (Ph.D.)--Boston UniversityPolybrominated diphenyl ethers (PBDEs) are a class of flame retardant chemicals that have been added to consumer products such as foam furniture and electronic equipment since the 1970s. Human exposure can occur when PBDEs are released to the environment. North Americans are among the most highly exposed populations, with median serum concentrations about an order of magnitude higher than European or Asian populations. Multiple animal studies have shown PBDEs to be thyroid hormone disruptors that may also adversely affect reproductive success. Limited human studies exist on the human health effects of PBDEs or their persistence in human tissues. We investigated exposure to PBDEs in a longitudinal cohort of 52 healthy adults within the Boston metropolitan area, hereafter referred to as the Flame Retardant Exposure (FlaRE) cohort. We followed individuals for approximately one year and collected serum samples and questionnaire data at three sampling intervals: Winter 2010, Summer 2010, and Winter 2011. Serum samples were analyzed for 11 PBDE congeners, thyroid function, and reproductive function tests. We used these data to assess the stability of PBDEs in serum measures, determine potential temporal trends in PBDE serum concentrations over 1 year, and assess the relationship between PBDE exposure and thyroid and reproductive function tests over time. In the FlaRE cohort, geometric mean sum concentrations of the five most prevalent PBDE congeners (BDE 28, 47, 99, 100, 153) were 21.8 ng/g lipid in Winter 2010, 22.8 ng/g lipid in Summer 2010, and 18.7 ng/g lipid in Winter 2011. We found that a single PentaBDE serum measurement is a stable estimate, either continuously or categorically, of a participant's blood concentration over the one-year study period. After adjustment of important confounders, we found that serum PentaBDE congeners were inversely associated with Total T4, which is consistent with animal experiments and some previous epidemiology studies. Among men 40 years or older, increased exposure to PentaBDEs was associated with a decrease in inhibin-B, an increase in follicular stimulating hormone, and decreases in the inhibin-B/FSH ratio thus indicating PBDE exposure may decrease testicular function in men

Generative pre-trained Transformer 3 (GPT-3)

In our time, he Internet has become an integral part of our life. Thanks to new technologies, our experience of using the global network has become even better. One of these technologies is GPT-3

Motivación y satisfacción laboral durante la pandemia COVID-19 en personal de obstetricia del Hospital Félix Mayorca Soto de Tarma, 2021

La investigación tiene el propósito de establecer la relación entre la motivación y la satisfacción laboral durante la pandemia covid-19 en el personal de obstetricia del HFMS de Tarma 2021. El diseño es no experimental, descriptivo correlacional de corte transversal, enfoque cuantitativo. La población de estudio estuvo constituida por 35 obstetras y el tipo de muestreo fue no censal. La técnica que se uso fue la encuesta y el instrumento para la recolección de datos fue el cuestionario, los datos procesados fueron arrojados en el SPPS 0.782 de confiabilidad de la primera variable motivación laboral, debido a ello podemos afirmar que existe razones suficientes para afirmar que el instrumento es aplicable, en la segunda variable de satisfacción laboral se tuvo 0.713 de confiabilidad. Como resultados obtenidos de las variables estudiadas serán obtenidas mediante las encuestas, que fueron registrados en el programa Excel y SPSS versión 25. Llegando como conclusión que existe relación entre la variable 1 con la variable 2

Baseline survey of Hinchinbrook region seagrasses - October (spring) 1996

Current coastal zone management issues in the Hinchinbrook region include protection of fisheries habitats, dugong habitat areas and increases in aquaculture, agriculture and tourist operations. A regional coastal management plan which is being developed, also requires detailed information on seagrass resources for the coastal zone from Dunk Island in the north, to Cleveland Bay in the south. Decreases in estimates of dugong abundance in the southern half of the Great Barrier Reef region since the 1980's have also prompted the need for detailed baseline and monitoring surveys of seagrasses in this and other regions

Co-production: what it is and how it can ensure inclusive practice for service users and staff.

Co-production is a process adopted in health, social care, research, policy development and higher education that aims to bring together the skills and experiences of service users and professionals. It has a range of advantages, such as enabling users of a service to have a voice and to equalise power among service users, professionals and leaders. Co-production is continually developing and is often referred to in contemporary health and social care policy. When designed well, co-production can create a variety of advantages for service users, professionals and the wider community. This article demonstrates that co-production can be an effective framework to improve experiences for service users and healthcare staff. It is an empowering process that can happen in varying degrees and can be a key part of nurse managers' practice. The article explores how co-production can be successfully used in a range of healthcare and higher education environments. Ideas about how nurse managers can use co-production to address diversity and inclusion in services are explored